Objective: To disclose possible influences of alcoholic beverages on restenosi s rate in men with coronary artery disease treated with percutaneous translumina l coronary angioplasty (PTCA) and stent implantation. Des...Objective: To disclose possible influences of alcoholic beverages on restenosi s rate in men with coronary artery disease treated with percutaneous translumina l coronary angioplasty (PTCA) and stent implantation. Design: Retrospective coho rt study. Patients: 225 consecutive male patients underwent PTCA and stent impla ntation. All patients had a control angiography and were contacted for a questio nnaire regarding their drinking habits. Main outcome measures: Mean late loss of luminal diameter, rate of coronary restenosis of 50%or more within the stented segment, and rate of repeat angioplasty. Results: 53 patients (with 80 stents) consumed< 50 g of alcohol a week and 172(with 266 stents) consumed more (50-700 g a week). Baseline characteristics were similar in both groups except for a hi gher prevalence of reduced cardiac function and multivessel disease and a lower high density lipoprotein cholesterol concentration among patients who consumed l ittle or no alcohol. Patients who consumed ≥50 g alcohol a week had a lower mea n late loss of the luminal diameter (1.1 (0.79)mm v 1.45 (0.82) mm, p=0.002), a lower rate of coronary restenosis within the stented segment (33.7%v 48.8%, p= 0.001), and a lower rate of repeat angioplasty(23.3%v 42.5%, p=0.002). In mult ivariate analysis, only alcohol consumption and diabetes were independent and si gnificant discriminators for late loss of luminal diameter (p=0.005 and p=0.01, respectively), restenosis(odds ratio 0.54 and 2.08, respectively), and repeat an gioplasty(odds ratio 0.39 and 2.18, respectively). Conclusion: Alcohol intake is associated with reduced restenosis after PTCA and stent implantation.展开更多
文摘Objective: To disclose possible influences of alcoholic beverages on restenosi s rate in men with coronary artery disease treated with percutaneous translumina l coronary angioplasty (PTCA) and stent implantation. Design: Retrospective coho rt study. Patients: 225 consecutive male patients underwent PTCA and stent impla ntation. All patients had a control angiography and were contacted for a questio nnaire regarding their drinking habits. Main outcome measures: Mean late loss of luminal diameter, rate of coronary restenosis of 50%or more within the stented segment, and rate of repeat angioplasty. Results: 53 patients (with 80 stents) consumed< 50 g of alcohol a week and 172(with 266 stents) consumed more (50-700 g a week). Baseline characteristics were similar in both groups except for a hi gher prevalence of reduced cardiac function and multivessel disease and a lower high density lipoprotein cholesterol concentration among patients who consumed l ittle or no alcohol. Patients who consumed ≥50 g alcohol a week had a lower mea n late loss of the luminal diameter (1.1 (0.79)mm v 1.45 (0.82) mm, p=0.002), a lower rate of coronary restenosis within the stented segment (33.7%v 48.8%, p= 0.001), and a lower rate of repeat angioplasty(23.3%v 42.5%, p=0.002). In mult ivariate analysis, only alcohol consumption and diabetes were independent and si gnificant discriminators for late loss of luminal diameter (p=0.005 and p=0.01, respectively), restenosis(odds ratio 0.54 and 2.08, respectively), and repeat an gioplasty(odds ratio 0.39 and 2.18, respectively). Conclusion: Alcohol intake is associated with reduced restenosis after PTCA and stent implantation.
