AIM To investigate the expression of integrinsin rats liver during 3’-Me-DAB inducedhepatocarcinogenesis and to find out therelationship between integrins and liver cancermetastasis.METHODS The expressions of integri...AIM To investigate the expression of integrinsin rats liver during 3’-Me-DAB inducedhepatocarcinogenesis and to find out therelationship between integrins and liver cancermetastasis.METHODS The expressions of integrins α<sub>1</sub>,α<sub>2</sub>,α<sub>3</sub> and α<sub>5</sub> and epidermal keratin（EK）wereobserved by immunohistochemical PAP method.RESULTS In the normal liver tissues,hepatocytes express integrins α<sub>1</sub> and α<sub>5</sub> and inthe bile duct epithlium,EK.In liver cirrhosis,hepatocytes highly express integrins α<sub>1</sub>,α<sub>2</sub>,α<sub>3</sub>and α<sub>5</sub> and in hyperplastic bile duct epithelium,integrins α<sub>1</sub>,α<sub>5</sub> and EK.Expression of integrinsα<sub>1</sub>,α<sub>2</sub>,α<sub>3</sub> and α<sub>5</sub> were obviously decreased in thepreneoplastic nodules and primary carcinomabut expressions of integrins α<sub>1</sub> and α<sub>5</sub> inmetastasis in the lung and diaphragma werehigher than those in primary carcinoma.CONCLUSION Integrins α<sub>1</sub> and α<sub>5</sub> may play amajor role in chemically inducedhepatocarcinogenesis and metastasis in rats.展开更多
基金The Ninth Five-Year Key Program of the Ministry of Health (JB02 96-906-01-15)
文摘AIM To investigate the expression of integrinsin rats liver during 3’-Me-DAB inducedhepatocarcinogenesis and to find out therelationship between integrins and liver cancermetastasis.METHODS The expressions of integrins α<sub>1</sub>,α<sub>2</sub>,α<sub>3</sub> and α<sub>5</sub> and epidermal keratin（EK）wereobserved by immunohistochemical PAP method.RESULTS In the normal liver tissues,hepatocytes express integrins α<sub>1</sub> and α<sub>5</sub> and inthe bile duct epithlium,EK.In liver cirrhosis,hepatocytes highly express integrins α<sub>1</sub>,α<sub>2</sub>,α<sub>3</sub>and α<sub>5</sub> and in hyperplastic bile duct epithelium,integrins α<sub>1</sub>,α<sub>5</sub> and EK.Expression of integrinsα<sub>1</sub>,α<sub>2</sub>,α<sub>3</sub> and α<sub>5</sub> were obviously decreased in thepreneoplastic nodules and primary carcinomabut expressions of integrins α<sub>1</sub> and α<sub>5</sub> inmetastasis in the lung and diaphragma werehigher than those in primary carcinoma.CONCLUSION Integrins α<sub>1</sub> and α<sub>5</sub> may play amajor role in chemically inducedhepatocarcinogenesis and metastasis in rats.
