Autophagy is a highly conserved process in which cytosolic contents are degraded by the lysosome,which plays an important role in energy and nutrient balance,and protein or organelle quality control.The liver is the m...Autophagy is a highly conserved process in which cytosolic contents are degraded by the lysosome,which plays an important role in energy and nutrient balance,and protein or organelle quality control.The liver is the most important organ for metabolism.Studies to date have revealed a significant role of autophagy in the maintenance of liver homeostasis under basal and stressed conditions,and the impairment of autophagy has been closely linked to various liver diseases.Therefore,a comprehensive understanding of the roles of autophagy in liver diseases may help in the development of therapeutic strategies via targeting autophagy.In this review,we will summarize the latest understanding of the molecular mechanisms of autophagy and systematically discuss its implications in various liver diseases,including alcohol-related liver disease,non-alcoholic fatty liver disease,viral hepatitis,hepatocellular carcinoma,and acetaminophen-induced liver injury.展开更多
基金supported by research grants from Guangzhou Basic and Applied Basic Research Foundation(Grant No.2023A04J1951)Guangdong Basic and Applied Basic Research Foundation(Grant No.2022A1515111047)funded by research grant from Guangdong Basic and Applied Basic Research Foundation(Grant No.2021A1515010999).
文摘Autophagy is a highly conserved process in which cytosolic contents are degraded by the lysosome,which plays an important role in energy and nutrient balance,and protein or organelle quality control.The liver is the most important organ for metabolism.Studies to date have revealed a significant role of autophagy in the maintenance of liver homeostasis under basal and stressed conditions,and the impairment of autophagy has been closely linked to various liver diseases.Therefore,a comprehensive understanding of the roles of autophagy in liver diseases may help in the development of therapeutic strategies via targeting autophagy.In this review,we will summarize the latest understanding of the molecular mechanisms of autophagy and systematically discuss its implications in various liver diseases,including alcohol-related liver disease,non-alcoholic fatty liver disease,viral hepatitis,hepatocellular carcinoma,and acetaminophen-induced liver injury.
