雷公藤甲素对系统性红斑狼疮BALB/c-un裸小鼠外周血Tc与Th细胞漂移的影响

目的:观察雷公藤甲素对Pristane(姥鲛烷)诱发的系统性红斑狼疮(systemic lupus erythematosus,SLE)BALB/c-un裸小鼠外周血Tc与Th细胞漂移的影响。方法:用随机表法将雌BALB/c-un裸小鼠18只机编号后随机均分为空白、SLE和雷公藤甲素3组,每组动物数6只。SLE组和雷公藤甲素组用Pristane单次腹腔注射的方法建立SLE模型,空白组作空白对照。雷公藤甲素组按5 mg/(kg·d)灌服雷公藤甲,空白组和SLE组正常饲喂。分别于治疗前、治疗后1、3和6个月从尾静脉采血,采用荧光标记的流式细胞术检查治疗不同阶段Tc与Th淋巴细胞亚群。结果:在治疗3和6个月时与SLE组同期比较,雷公藤甲素组Tcl、Thl细胞和CD8+百分比、Tcl/Tc2,Thl/Th2和CD4+/CD8+比值均降低,而CD4+、Tc2和Th2细胞百分比均明显升高(P<0.05)。结论:雷公藤甲素治疗SLE的机制可能与其调节Tc与Th细胞向Tcl和Tc2漂移,维持治疗不同阶段Tc与Th细胞相对稳态而影响免疫应答及炎症反应过程有关。

Clinical Study on Surrounding Acupuncture for Herpes Zoster

Objective:To observe the clinical effects of the surrounding acupuncture for herpes zoster.Methods:Sixty patients with herpes zoster were randomly divided into two groups,a treatment group and a control group,30 cases in each.The cases in the treatment group were treated with surrounding acupuncture,intravenous infusion of Acyclovir and Ne-Ne laser radiation on the macular areas.While,those in the control group were treated with intravenous infusion of Acyclovir and topical application of Acyclovir ointment.The therapeutic effects were assessed in both groups after two courses of treatment.Results:The treatment group was obviously better than the control group in the effective rate,relief of blister,drying up of blister,relief of pain and time of complete relief of pain(P<0.05).Conclusion:Surrounding acupuncture,combined with intravenous infusion of Acyclovir and He-Ne laser radiation,is remarkable in the therapeutic effects for herpes zoster and worthy of clinical application.