Objective:To systematically study the key active ingredients of Jiuwei Huaban pill in the treatment of psoriasis and explore its mechanism of action.Methods:The chemical components of Jiuwei Huaban pill were systemati...Objective:To systematically study the key active ingredients of Jiuwei Huaban pill in the treatment of psoriasis and explore its mechanism of action.Methods:The chemical components of Jiuwei Huaban pill were systematically identified by UPLC-QTOF/MSE,and network pharmacology method was used to study the main pharmacodynamic substances of Jiuwei Huaban pill and discuss the mechanism of action.Molecular docking technology was used to verify the binding activity of key components and target proteins.Results:A total of 75 components of Jiuwei Huaban pill were identified,35 of which were key components for psoriasis treatment,including luteolin,baicalin,baicalin,paeoniflorin and geniposide.Enrichment analysis of 30 core target pathways showed that Jiuwei Huaban pill played its role in the treatment of psoriasis from the IL-17 signaling pathway,TNF signaling pathway,PI3K-Akt signaling pathway,Th17 signaling pathway,and MAPK signaling pathway.The key active components in Jiuwei Huaban pill and targets with the highest DGREE value in the"component target disease"network have strong binding activity.Conclusion:The active ingredients and mechanism of action of Jiuwei Huaban pill in the treatment of psoriasis were preliminarily clarified,which provids reference for quality control.展开更多
Globalization facilitates the transnational and trans-regional flow of population.As new comers,immigrants need to adapt to new culture and conventions.The way of acculturation varies from individuals even within an i...Globalization facilitates the transnational and trans-regional flow of population.As new comers,immigrants need to adapt to new culture and conventions.The way of acculturation varies from individuals even within an immigrant family,with a problematic asymmetry that children acculturate faster than their last generations,as the acculturation gap-distress model demonstrates.However,empirical studies indicate that acculturation gap does not always associate with family and youth maladjustment,and parent’s attitude towards the host and origin culture rarely influences children.This paper analyses Fresh Off the Boat,a teleplay adapted from a Chinese American writer Eddie Huang’s memoir,to revile how different generation immigrants adapt to their new life.This paper finds that parents’orientations to Chinese and American culture affect their children,which is different from the previous study.Findings suggest that maintaining heritage culture is important for young immigrants’adjustment,while accepting host culture is crucial for their parents.Therefore,adopting a strategy of integration may be the ideal way of acculturation.展开更多
基金National Major Science and Technology Project for"Major New Drug Development"(No.2017ZX09301005)。
文摘Objective:To systematically study the key active ingredients of Jiuwei Huaban pill in the treatment of psoriasis and explore its mechanism of action.Methods:The chemical components of Jiuwei Huaban pill were systematically identified by UPLC-QTOF/MSE,and network pharmacology method was used to study the main pharmacodynamic substances of Jiuwei Huaban pill and discuss the mechanism of action.Molecular docking technology was used to verify the binding activity of key components and target proteins.Results:A total of 75 components of Jiuwei Huaban pill were identified,35 of which were key components for psoriasis treatment,including luteolin,baicalin,baicalin,paeoniflorin and geniposide.Enrichment analysis of 30 core target pathways showed that Jiuwei Huaban pill played its role in the treatment of psoriasis from the IL-17 signaling pathway,TNF signaling pathway,PI3K-Akt signaling pathway,Th17 signaling pathway,and MAPK signaling pathway.The key active components in Jiuwei Huaban pill and targets with the highest DGREE value in the"component target disease"network have strong binding activity.Conclusion:The active ingredients and mechanism of action of Jiuwei Huaban pill in the treatment of psoriasis were preliminarily clarified,which provids reference for quality control.
文摘Globalization facilitates the transnational and trans-regional flow of population.As new comers,immigrants need to adapt to new culture and conventions.The way of acculturation varies from individuals even within an immigrant family,with a problematic asymmetry that children acculturate faster than their last generations,as the acculturation gap-distress model demonstrates.However,empirical studies indicate that acculturation gap does not always associate with family and youth maladjustment,and parent’s attitude towards the host and origin culture rarely influences children.This paper analyses Fresh Off the Boat,a teleplay adapted from a Chinese American writer Eddie Huang’s memoir,to revile how different generation immigrants adapt to their new life.This paper finds that parents’orientations to Chinese and American culture affect their children,which is different from the previous study.Findings suggest that maintaining heritage culture is important for young immigrants’adjustment,while accepting host culture is crucial for their parents.Therefore,adopting a strategy of integration may be the ideal way of acculturation.