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外泌体在骨关节炎发病及治疗中的作用和机制研究 被引量:3
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作者 王刘欣 王贺林 张勉 《中国现代医学杂志》 CAS 北大核心 2022年第18期63-69,共7页
外泌体是源于细胞内部消化过程中的细胞膜的一种分泌小泡,在细胞间的交流中起到重要作用。外泌体来源多样,不同来源的外泌体作用也不尽相同。随着近年来对外泌体的深入研究,越来越多的资料显示外泌体在骨关节炎等关节疾病的发病与治疗... 外泌体是源于细胞内部消化过程中的细胞膜的一种分泌小泡,在细胞间的交流中起到重要作用。外泌体来源多样,不同来源的外泌体作用也不尽相同。随着近年来对外泌体的深入研究,越来越多的资料显示外泌体在骨关节炎等关节疾病的发病与治疗中发挥重要作用,骨关节炎患者来源细胞中的外泌体内含有多种生物活性分子,可促进炎症因子的产生,进而导致软骨退化,加重关节破坏。来自间充质干细胞的外泌体还参与了修复关节和延缓关节疾病的进程,为骨关节疾病提供了新的治疗思路。该文主要对近年来关于外泌体在骨关节炎疾病发展进程中的作用和机制的文献进行综述,对未来外泌体在骨关节炎的诊断与治疗中的应用进行展望。 展开更多
关键词 骨关节炎 外泌体 MIRNA 炎症因子 细胞外基质
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Pressure dependent modulation instability in photonic crystal fiber filled with argon gas
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作者 he-lin wang Ai-Jun Yang +2 位作者 XiaoLong wang Bin Wu Yi Ruan 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第9期338-341,共4页
By using the designed photonic crystal fiber filled with argon gas, the effect of gas pressure on modulation instability(MI) gain is analyzed in detail. The MI gain bandwidth increases gradually as the argon gas pre... By using the designed photonic crystal fiber filled with argon gas, the effect of gas pressure on modulation instability(MI) gain is analyzed in detail. The MI gain bandwidth increases gradually as the argon gas pressure rises from 1 P0 to 400 P0(P0 is one standard atmosphere), while its gain amplitude slightly decreases. Moreover, the increase of the incident light power also results in the increase of MI gain bandwidth in the Stokes or anti-Stokes region when the incident power increases from 1 W to 200 W. Making use of the optimal parameters including the higher argon gas pressure(400 P0) and the incident light power(200 W), we finally obtain a 100 nm broadband MI gain. These results indicate that controlling the MI gain characteristic by changing the argon gas pressure in PCF is an effective way when the incident light source is not easy to satisfy the requirement of practical application. This method of controlling MI gain can be used in optical communication and laser shaping. 展开更多
关键词 modulation instability gas pressure light power.broadband gain
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