Pericyte,a kind of pluripotent cell,may regulate the irigation flow and permeability of microcirculation.Pericytes are similar to the smooth muscle cells,which express several kinds of contractile proteins and have co...Pericyte,a kind of pluripotent cell,may regulate the irigation flow and permeability of microcirculation.Pericytes are similar to the smooth muscle cells,which express several kinds of contractile proteins and have contractility.The dysfunction of pericytes is related to many microvascular diseases,including hypoxia,hypertension,diabetic retinopathy,fibrosis,inflammation,Alzheimer's disease,multiple scle-rosis,and tumor formation.For a long time,their existence and function have been neglected.The distribution,structure,biomarker,related signaling pathways as well as the roles of pericytes on vascular diseases will be introduced in this review.展开更多
基金This study was supported by the Key Projects and innovation group of National Natural Science Foundation of China(81830065,81721001).
文摘Pericyte,a kind of pluripotent cell,may regulate the irigation flow and permeability of microcirculation.Pericytes are similar to the smooth muscle cells,which express several kinds of contractile proteins and have contractility.The dysfunction of pericytes is related to many microvascular diseases,including hypoxia,hypertension,diabetic retinopathy,fibrosis,inflammation,Alzheimer's disease,multiple scle-rosis,and tumor formation.For a long time,their existence and function have been neglected.The distribution,structure,biomarker,related signaling pathways as well as the roles of pericytes on vascular diseases will be introduced in this review.
