Background We aimed to evaluate the tolerability and efficacy of linezolid in children for treating suspected and diagnosed Gram-positive bacterial infections.Methods A systematic literature search was conducted up to...Background We aimed to evaluate the tolerability and efficacy of linezolid in children for treating suspected and diagnosed Gram-positive bacterial infections.Methods A systematic literature search was conducted up to April 23,2021,using linezolid and its synonyms as search terms.Two reviewers independently identified and extracted relevant randomized controlled trials and prospective cohort studies.The extracted studies were included in a single-rate meta-analysis of adverse events and clinical outcomes using random-effects models.Results A total of 1082 articles were identified,and nine studies involving 758 children were included in the meta-analysis.The overall proportion of adverse events was 8.91%[95%confidence interval(CI)=1.64%–36.52%],with diarrhea(2.24%),vomiting(2.05%),and rash(1.72%)being the most common.The incidences of thrombocytopenia and anemia were 0.68%and 0.16%,respectively.Some specific adverse events,including rash and gastrointestinal events,were more frequent in the oral administration subgroup.In terms of efficacy,the overall proportion of clinical improvement was 88.80%(95%CI=81.31%–93.52%).Children with a history of specific bacteriological diagnosis or concomitant antibiotic therapy had a 1.13-fold higher clinical improvement than children without such histories.The proportion of microbial eradication was 92.68%(95%CI=84.66%–96.68%).The proportion of all-cause mortality was 0.16%(95%CI=0.00%–7.75%).Conclusions Linezolid was well-tolerated in pediatric patients and was associated with a low frequency of adverse events,such as anemia,thrombocytopenia,and neutropenia.Moreover,linezolid was effective in children with diagnosed and suspected Gram-positive infections.展开更多
Bile acid synthetic defect （BASD） is a rare category of genetic disorders that are responsible for approximately 2% of persistent cholestasis in infants. Until date, four enzynles responsible for congenital defects ...Bile acid synthetic defect （BASD） is a rare category of genetic disorders that are responsible for approximately 2% of persistent cholestasis in infants. Until date, four enzynles responsible for congenital defects of bile acid synthesis （CBAS） have been identified. 313-hydroxy-A5-C27-steroid dehydrogenase （3β-HSD）, the deficiency of which can cause CBAS 1 （OMIM No. 607765）, is encoded by the gene HSD3B7 and works in the second step of transforming the steroid into primary bile acids.展开更多
基金National Natural Science Foundation of China(Nos.81874265,82073561)Shanghai Jiao Tong University School of Medicine(No.2020002)+3 种基金Shanghai Science and Technology Commission(Nos.18411966600,19410740800)Key Discipline Construction Plan from Shanghai Municipal Health Commission(No.GWV-10.1-XK01)National Ministry of Science and Technology-National Key R&D Program Project(No.2021YFE0201900)and National Respiratory Field Key Laboratory Emergency Project(No.EKPG21-08).
文摘Background We aimed to evaluate the tolerability and efficacy of linezolid in children for treating suspected and diagnosed Gram-positive bacterial infections.Methods A systematic literature search was conducted up to April 23,2021,using linezolid and its synonyms as search terms.Two reviewers independently identified and extracted relevant randomized controlled trials and prospective cohort studies.The extracted studies were included in a single-rate meta-analysis of adverse events and clinical outcomes using random-effects models.Results A total of 1082 articles were identified,and nine studies involving 758 children were included in the meta-analysis.The overall proportion of adverse events was 8.91%[95%confidence interval(CI)=1.64%–36.52%],with diarrhea(2.24%),vomiting(2.05%),and rash(1.72%)being the most common.The incidences of thrombocytopenia and anemia were 0.68%and 0.16%,respectively.Some specific adverse events,including rash and gastrointestinal events,were more frequent in the oral administration subgroup.In terms of efficacy,the overall proportion of clinical improvement was 88.80%(95%CI=81.31%–93.52%).Children with a history of specific bacteriological diagnosis or concomitant antibiotic therapy had a 1.13-fold higher clinical improvement than children without such histories.The proportion of microbial eradication was 92.68%(95%CI=84.66%–96.68%).The proportion of all-cause mortality was 0.16%(95%CI=0.00%–7.75%).Conclusions Linezolid was well-tolerated in pediatric patients and was associated with a low frequency of adverse events,such as anemia,thrombocytopenia,and neutropenia.Moreover,linezolid was effective in children with diagnosed and suspected Gram-positive infections.
文摘Bile acid synthetic defect （BASD） is a rare category of genetic disorders that are responsible for approximately 2% of persistent cholestasis in infants. Until date, four enzynles responsible for congenital defects of bile acid synthesis （CBAS） have been identified. 313-hydroxy-A5-C27-steroid dehydrogenase （3β-HSD）, the deficiency of which can cause CBAS 1 （OMIM No. 607765）, is encoded by the gene HSD3B7 and works in the second step of transforming the steroid into primary bile acids.
