Pharmacokinetic Analysis of Four Bioactive Iridoid and Secoiridoid Glycoside Components of Radix Gentianae Macrophyllae and Their Synergistic Excretion by HPLC-DAD Combined with Second-Order Calibration

An HPLC-DAD method combined with second-order calibration based on the alternating trilinear decomposition(ATLD)algorithm with the aid of region selection was developed to simultaneously and quantitatively characterize the synergistic relationships and cumulative excretion of the four bioactive ingredients of Radix Gentianae Macrophyllae in vivo.Although the analytes spectra substantially overlapped with that of the biological matrix,the overlapping profiles between analytes and co-eluting interferences can be successfully separated and accurately quantified by the ATLD method on the basis of the strength of region selection.The proposed approach not only determined the content change but also revealed the synergistic relationships and the cumulative excretion in vivo of the four ingredients in urine and feces samples collected at different excretion time intervals.In addition,several statistical parameters were employed to evaluate the accuracy and precision of the method.Quantitative results were confirmed by HPLC-mass spectrometry.Satisfactory results indicated that the proposed approach can be utilized to investigate the pharmacokinetics of Radix Gentianae Macrophyllae excretion in vivo.

Effects of nanoclay addition on the permeability and mechanical properties of ultra high toughness cementitious composites

Tuning microstructures by adding nanoparticles is a promising way of improving the performance of cementitious composites.In this study,nanoclay was introduced to polyvinyl alcohol(PVA)fiber reinforced ultra high toughness cementitious composites(UHTCCs).The mechanical properties,crack patterns,water permeation resistance,and microstructures of UHTCCs with different dosages of nanoclay were studied.The addition of a proper dosage of nanoclay shows few effects on the compressive strength of UHTCCs,however,the compressive strength is decreased when an excessive amount of nanoclay is added.The flexural deformation capacity of UHTCCs is independent of nanoclay dosage,whereas the flexural strength generally decreases with an increasing dosage of nanoclay.Different cracking patterns were observed in the ultra high toughness cementitious composites containing nanoclay(NC-UHTCC)specimens subject to bending tests.A UHTCC with 1%(in weight)nanoclay shows the best water permeation resistance and the lowest water permeability.Variations in the mechanical properties and the water permeation resistance of UHTCCs containing different dosages of nanoclay could be ascribed to the synthetic effects of filling and heterogeneous nucleation of nanoclay at low dosages and the agglomeration effect of nanoclay at high dosages.This study is to optimize the water permeation resistance of UHTCCs,paving a path for the future application of UHTCCs in the fields of construction,decoration,and repair.

干热养护对活性粉末混凝土力学及收缩影响研究（英文）

目的:高温干热养护工艺对活性粉末混凝土的力学强度及收缩性能有重要影响。本文针对不同的高温养护温度和时间分析活性粉末混凝土材料的抗压强度、抗折强度、收缩和微观结构,探索高温干热养护环境提升活性粉末混凝土材料力学性能的机理,并讨论外部环境湿度对材料收缩变形的影响。创新点:1.通过调整不同养护工艺参数,大幅度提升活性粉末混凝土的早期强度;2.建立试验模型,成功模拟适应性冲压工艺过程。方法:1.通过实验分析,研究不同养护温度和养护时间对活性粉末混凝土力学强度的影响(表4);2.通过设计不同的养护湿度(50%和90%),构建后期养护环境与材料干燥收缩之间的关系,得到适应性的后期养护参数(表5);3.通过与已有研究的分析对比,提出适用于工程实际的高温干热养护工艺参数,并得出后期高湿度养护降低活性粉末混凝土收缩的微观机理(图7)。结论:1.通过调整高温养护的温度和养护时间可以对活性粉末混凝土的强度产生影响。2.试件在经历高温养护后再进行高湿度养护可以有效降低材料的后期干燥收缩。3.材料界面过渡区在高温养护条件下变得更加密实;在高温环境下生成托勃莫来石或硬硅钙石是材料获得较高强度的主要原因。

超高韧性水泥基复合材料直接拉伸特性应变率效应研究（英文）

目的:水泥基材料的拉伸性能会随着荷载速率的变化而变化。本文旨在探讨加载速率为4×10^(-6)~1×10^(-1) s^(-1)时,超高韧性水泥基复合材料直接拉伸初裂抗拉强度、初裂抗拉应变、弹性模量、极限抗拉应变、极限抗拉强度、多缝开裂特性和耗能能力的变化规律,为超高韧性水泥基复合材料在抗震工程中的应用提供必要的科学依据和参考。创新点:1.通过直接拉伸试验较为全面地测定超高韧性水泥基复合材料在4×10^(-6)~1×10^(-1) s^(-1)应变速率范围内的直接拉伸性能;2.建立适宜的拟合方程,可直观反映多种直接拉伸性能指标随应变率的变化规律。方法:1.通过直接拉伸试验,确定加载速率对超高韧性直接拉伸特性的影响(图2和4);2.通过对实验结果的拟合,简单直观地反映应变率对拉伸弹性模量、初裂抗拉强度和极限抗拉强度的影响规律(图3、5和7)。结论:基于超高韧性水泥基复合材料薄板直接拉伸试验,当应变速率在4×10^(-6)~1×10^(-1) s^(-1)的范围内变化时:1.材料的初裂抗拉强度、初裂抗拉应变、拉伸弹性模量、极限抗拉强度和耗能能力都具有应变速率敏感性,其中除初裂抗拉应变随应变率升高而减小外,其它几项性能指标都显示出明显的动态强化效应;2.多缝开裂模式和极限抗拉应变对应变率不敏感,极限裂缝宽度始终在100μm以内,极限抗拉应变保持在3.7%左右;3.应变率对初裂抗拉强度、拉伸弹性模量、极限抗拉强度和耗能能力的动态增强效应都存在一个阈值(皆在1×10^(-3) s^(-1)附近),在应变率达到阈值之后,动态效应才更加显著;4.超高韧性水泥基复合材料具有明显优于混凝土的耗能能力,在地震荷载(对应应变率在1×10-4~1×10-2 s^(-1))作用下其耗能能力可达C20混凝土的1000倍。