Purpose: To describe the baseline data of a large cohort of patients included for follow-up with perimetry using the frequency doubling technique (FDT) and w ith quantification of the retinal nerve fibre layer as asse...Purpose: To describe the baseline data of a large cohort of patients included for follow-up with perimetry using the frequency doubling technique (FDT) and w ith quantification of the retinal nerve fibre layer as assessed by GDx, and to c alculate the sensitivity and specificity of both devices from these baseline dat a. Methods: Regular visitors to our glaucoma service were included. All subjects were followed for at least 4 years with FDT in full-threshold mode, GDx and co nventional perimetry. Patients were classified as having either glaucoma or susp ect glaucoma, according to baseline perimetry results. In addition, a group of h ealthy subjects was recruited outside the hospital. Results: A total of 452 glau coma patients, 423 glaucoma suspects and 237 healthy subjects were incorporated into the analyses. Sensitivities for both FDT and GDx were fixed at 0.90. For th e group as a whole, the specificity was 0.81 for FDT, using number of depressed test-points p <0.01 in the total deviation probability plot with a cut-off poi nt >1, and 0.78 for GDx, using the Number, with a cut-off point >29. The area u nder the receiver operating characteristic (ROC)curve was 0.92 for FDT and 0.94 for GDx. Of the subjects with suspect glaucoma, 75%showed normal FDT test resul ts and 52%showed normal GDx results. Unlike FDT, GDx failed to detect some mode rate/severe glaucoma cases. Conclusions: The performances of FDT and GDx are app roximately equivalent in terms of sensitivity, specificity and area under the RO C curve. In glaucoma suspects, GDx in particular yielded a rather high percentag e of positive test results. The majority of these positive test results are pres umably false-positive results rather than results indicating preperimetric glau coma.展开更多
Purpose: To evaluate various strategies designed to improve the specificity of the interpretation of results obtained with the frequency doubling technology p erimeter (FDT) used in the full-threshold mode. Methods: T...Purpose: To evaluate various strategies designed to improve the specificity of the interpretation of results obtained with the frequency doubling technology p erimeter (FDT) used in the full-threshold mode. Methods: Three different strate gies were compared using data from 452 glaucoma patients and 237 healthy subject s: combining several FDT parameters from a single test, combining the FDT test with a GDx test, and confirming an abnormal FDT test result with a repeat test. R esults: Confirming an abnormal FDT test result with a repeat test yielded a spec ificity increase of 0.10, from 0.80 to 0.90, at the expense of some loss of sens itivity for early but not for moderate or severe glaucoma. Combining several FDT parameters from a single test and combining FDT with GDx did not yield any noti ceable increase in diagnostic performance. Conclusions: A modest increase in FDT diagnostic performance can be obtained by the confirmation of an abnormal test result with a repeat test.展开更多
文摘Purpose: To describe the baseline data of a large cohort of patients included for follow-up with perimetry using the frequency doubling technique (FDT) and w ith quantification of the retinal nerve fibre layer as assessed by GDx, and to c alculate the sensitivity and specificity of both devices from these baseline dat a. Methods: Regular visitors to our glaucoma service were included. All subjects were followed for at least 4 years with FDT in full-threshold mode, GDx and co nventional perimetry. Patients were classified as having either glaucoma or susp ect glaucoma, according to baseline perimetry results. In addition, a group of h ealthy subjects was recruited outside the hospital. Results: A total of 452 glau coma patients, 423 glaucoma suspects and 237 healthy subjects were incorporated into the analyses. Sensitivities for both FDT and GDx were fixed at 0.90. For th e group as a whole, the specificity was 0.81 for FDT, using number of depressed test-points p <0.01 in the total deviation probability plot with a cut-off poi nt >1, and 0.78 for GDx, using the Number, with a cut-off point >29. The area u nder the receiver operating characteristic (ROC)curve was 0.92 for FDT and 0.94 for GDx. Of the subjects with suspect glaucoma, 75%showed normal FDT test resul ts and 52%showed normal GDx results. Unlike FDT, GDx failed to detect some mode rate/severe glaucoma cases. Conclusions: The performances of FDT and GDx are app roximately equivalent in terms of sensitivity, specificity and area under the RO C curve. In glaucoma suspects, GDx in particular yielded a rather high percentag e of positive test results. The majority of these positive test results are pres umably false-positive results rather than results indicating preperimetric glau coma.
文摘Purpose: To evaluate various strategies designed to improve the specificity of the interpretation of results obtained with the frequency doubling technology p erimeter (FDT) used in the full-threshold mode. Methods: Three different strate gies were compared using data from 452 glaucoma patients and 237 healthy subject s: combining several FDT parameters from a single test, combining the FDT test with a GDx test, and confirming an abnormal FDT test result with a repeat test. R esults: Confirming an abnormal FDT test result with a repeat test yielded a spec ificity increase of 0.10, from 0.80 to 0.90, at the expense of some loss of sens itivity for early but not for moderate or severe glaucoma. Combining several FDT parameters from a single test and combining FDT with GDx did not yield any noti ceable increase in diagnostic performance. Conclusions: A modest increase in FDT diagnostic performance can be obtained by the confirmation of an abnormal test result with a repeat test.
