Summary of main observation and conclusion A Cu(I)-catalyzed three-component reaction of terminal enynals/enynones,diazo compounds,and al kenes has been developed.With this method,a series of oxabicyclo[2.2.2]octanes ...Summary of main observation and conclusion A Cu(I)-catalyzed three-component reaction of terminal enynals/enynones,diazo compounds,and al kenes has been developed.With this method,a series of oxabicyclo[2.2.2]octanes were effectively synthesized in high yields under mild reaction condi-tions.This transformation is proposed to proceed through trapping of the cyclic vinyl-o-quinodimethanes(vinyI-o-QDMs)species,which were generated from terminal enynals/enynones and diazo compounds by alkenes.The obvious advantages of wide substrate scopes,mild reaction conditions,and high seteroselectivity and atom eficiency make this reaction highly appealing for construction of highly rigid[2.2.2]octane skeleton.展开更多
基金We appreciate financial support from Ministry of Science and Technology of the People's Republic of China(2016YFA0602900)the National Natural Science Foundation of China(21871096,21672071)+1 种基金Guangdong Science and Technology Department(20188030308007,2018A030310359,2016A030310433)the Science and Technology Program of Guangzhou(201707010316,201707010168).
文摘Summary of main observation and conclusion A Cu(I)-catalyzed three-component reaction of terminal enynals/enynones,diazo compounds,and al kenes has been developed.With this method,a series of oxabicyclo[2.2.2]octanes were effectively synthesized in high yields under mild reaction condi-tions.This transformation is proposed to proceed through trapping of the cyclic vinyl-o-quinodimethanes(vinyI-o-QDMs)species,which were generated from terminal enynals/enynones and diazo compounds by alkenes.The obvious advantages of wide substrate scopes,mild reaction conditions,and high seteroselectivity and atom eficiency make this reaction highly appealing for construction of highly rigid[2.2.2]octane skeleton.
