Conventionally synthesized silver nanoparticles(AgNP)imposed an alarming effect on the environment and caused toxicity to humans.However,the use of zeolite(zeoY)as a support system could increase its biocompatibility ...Conventionally synthesized silver nanoparticles(AgNP)imposed an alarming effect on the environment and caused toxicity to humans.However,the use of zeolite(zeoY)as a support system could increase its biocompatibility and reduce its toxicity.Hence,green synthesis of AgNP using Persicaria odorata leaves extract supported on zeolite Y has been prepared by an in situ synthesis technique.The phytochemical compounds in the optimized leaf extract concentration of 1%and volume of 0.9 mL reduced the silver ions to AgNP within the zeolite Y pores.Morphological observation revealed the incorporation of AgNP in the zeolite Y(average size:18.51 nm).The release of AgNP exhibited antibacterial activity on C.acnes at a concentration lower than 1 g L^(−1) which is also dependent on the electrolyte.AgNP-zeoY promoted cell proliferation in vitro and it has a non-irritating effect when tested in the in vivo skin irritation model.展开更多
基金The authors would like to thank the Malaysia Ministry of Higher Education and Universiti Teknologi Malaysia for financial support under Industry/International Incentive Grant(IIIG)(Vot No 02M61)and Professional Development Research University(Vot No 06E23).
文摘Conventionally synthesized silver nanoparticles(AgNP)imposed an alarming effect on the environment and caused toxicity to humans.However,the use of zeolite(zeoY)as a support system could increase its biocompatibility and reduce its toxicity.Hence,green synthesis of AgNP using Persicaria odorata leaves extract supported on zeolite Y has been prepared by an in situ synthesis technique.The phytochemical compounds in the optimized leaf extract concentration of 1%and volume of 0.9 mL reduced the silver ions to AgNP within the zeolite Y pores.Morphological observation revealed the incorporation of AgNP in the zeolite Y(average size:18.51 nm).The release of AgNP exhibited antibacterial activity on C.acnes at a concentration lower than 1 g L^(−1) which is also dependent on the electrolyte.AgNP-zeoY promoted cell proliferation in vitro and it has a non-irritating effect when tested in the in vivo skin irritation model.
