Over 2 billion people worldwide are estimated to have nonalcoholic fatty liver disease(NAFLD),defined by excess hepatic fat.Commonly,progression into nonalcoholic steatohepatitis(NASH)is characterized by the onset of ...Over 2 billion people worldwide are estimated to have nonalcoholic fatty liver disease(NAFLD),defined by excess hepatic fat.Commonly,progression into nonalcoholic steatohepatitis(NASH)is characterized by the onset of liver inflammation following exacerbated steatosis.1 This suggests that reducing liver inflammation(e.g.through lifestyle interventions involving exercise training)may come secondary to a reduction of steatosis.However,both the metabolic and inflammatory processes involved in NAFLD are under circadian control and could respond differently to exercise at different times of day.2 To investigate the time-of-day–dependent effect of exercise training on NAFLD amelioration in the early disease stages we trained high-fat high-cholesterol(HFHC)-fed APOE*3-Leiden cholesteryl ester transfer protein(CETP)mice during their early or late active period.This mouse model was chosen because of its humanized lipid metabolism and its ability to develop all hallmarks of human NAFLD upon HFHC feeding.展开更多
基金financed by a grant from the Novo Nordisk Foundation to MS(NNF18OC0032394).
文摘Over 2 billion people worldwide are estimated to have nonalcoholic fatty liver disease(NAFLD),defined by excess hepatic fat.Commonly,progression into nonalcoholic steatohepatitis(NASH)is characterized by the onset of liver inflammation following exacerbated steatosis.1 This suggests that reducing liver inflammation(e.g.through lifestyle interventions involving exercise training)may come secondary to a reduction of steatosis.However,both the metabolic and inflammatory processes involved in NAFLD are under circadian control and could respond differently to exercise at different times of day.2 To investigate the time-of-day–dependent effect of exercise training on NAFLD amelioration in the early disease stages we trained high-fat high-cholesterol(HFHC)-fed APOE*3-Leiden cholesteryl ester transfer protein(CETP)mice during their early or late active period.This mouse model was chosen because of its humanized lipid metabolism and its ability to develop all hallmarks of human NAFLD upon HFHC feeding.
