高压隔离开关故障分析及对策

介绍电力机车新型高压隔离开关的结构和工作原理,以及高压隔离开关的控制逻辑。对发生带载分断故障进行还原和原因分析,并提出相应的对策。优化后,高压隔离开关稳定运行半年以上,实践证明解决措施有效。

A Clinical and Animal Experiment Integrated Platform for Small-Molecule Screening Reveals Potential Targets of Bioactive Compounds from a Herbal Prescription Based on the Therapeutic Efficacy of Yinchenhao Tang for Jaundice Syndrome

A herbal prescription in traditional Chinese medicine(TCM)has great complexity,with multiple components and multiple targets,making it extremely challenging to determine its bioactive compounds.Yinchenhao Tang(YCHT)has been extensively used for the treatment of jaundice disease.Although many studies have examined the efficacy and active ingredients of YCHT,there is still a lack of an in-depth systematic analysis of its effective components,mechanisms,and potential targets—especially one based on clinical patients.This study established an innovative strategy for discovering the potential targets and active compounds of YCHT based on an integrated clinical and animal experiment platform.The serum metabolic profiles and constituents of YCHT in vivo were determined by ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry(UPLC-Q-ToF-MS)-based metabolomics combined with a serum pharmacochemistry method.Moreover,a compound–target–pathway network was constructed and analyzed by network pharmacology and ingenuity pathway analysis(IPA).We found that eight active components could modulate five key targets.These key targets were further verified by enzyme-linked immunosorbent assay(ELISA),which indicated that YCHT exerts therapeutic effects by targeting cholesterol 7a-hydroxylase(CYP7A1),multidrug-resistance-associated protein 2(ABCC2),multidrug-resistance-associated protein 3(ABCC3),uridine diphosphate glucuronosyl transferase 1A1(UGT1A1),and farnesoid X receptor(FXR),and by regulating metabolic pathways including primary bile acid biosynthesis,porphyrin and chlorophyll metabolism,and biliary secretion.Eight main effective compounds were discovered and correlated with the key targets and pathways.In this way,we demonstrate that this integrated strategy can be successfully applied for the effective discovery of the active compounds and therapeutic targets of an herbal prescription.

A pseudocapacitive molecule-induced strategy to construct flexible high-performance asymmetric supercapacitors

The combination of high-voltage windows and bending stability remains a challenge for supercapacitors.Here,we present an“advantage-complementary strategy”using sodium lignosulfonate as a pseudocapacitive molecule to regulate the spatial stacking pattern of graphene oxide and the interfacial architectures of graphene oxide and polyaniline.Flexible and sustainable sodium lignosulfonate-based electrodes are successfully developed,showing perfect bending stability and high electronic conductivity and specific capacitance(521 F·g^(−1)at 0.5 A·g^(−1)).Due to the resulting rational interfacial structure and stable ion-electron transport,the asymmetric supercapacitors provide a wide voltage window reaching 1.7 V,outstanding bending stability and high energy-power density of 83.87 Wh·kg^(−1)at 3.4 kW·kg^(−1).These properties are superior to other reported cases of asymmetric energy enrichment.The synergistic strategy of sodium lignosulfonate on graphene oxide and polyaniline is undoubtedly beneficial to advance the process for the construction of green flexible supercapacitors with remarkably wide voltage windows and excellent bending stability.

后双奥时代既有体育建筑多场景运维智慧化整合框架

既有体育建筑全时可持续运维是当今体育建筑高质量发展的共识,多场景运维转换是实现这一目标的关键路径。基于领域本体及知识图谱理论方法,构建以运维场景、转换要素为核心的体育建筑多场景运维的知识组织和数据交互体系,将为既有体育场馆更新改造的建筑策划、设计、建造与运维提供智慧化整合支持。

High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome as potential targets for evaluating the therapeutic effects and mechanism of geniposide

High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitative and quantitative analysis of metabolites.This study used the established Yang Huang syndrome(YHS)mouse model to evaluate the efficacy of geniposide(GEN).Urine metabolic data were quantified by ultraperformance liquid chromatography-tandem mass spectrometry.The non-target screening of the massive biological information dataset was performed,and a total of 33 metabolites,including tyramine glucuronide,aurine,and L-cysteine,were identified relating to YHS.These differential metabolites directly participated in the disturbance of phase I reaction and hydrophilic transformation of bilirubin.Interestingly,they were completely reversed by GEN.While,as the auxiliary technical means,we also focused on the molecular prediction and docking results in network pharmacological and integrated analysis part.We used integrated analysis to communicate the multiple results of metabolomics and network pharmacology.This study is the first to report that GEN indirectly regulates the metabolite“tyramine glucuronide”through its direct effect on the target heme oxygenase 1 in vivo.Meanwhile,heme oxygenase-1,a prediction of network pharmacology,was the confirmed metabolic enzyme of phase I reaction in hepatocytes.Our study indicated that the combination of high-throughput metabolomics and network pharmacology is a robust combination for deciphering the pathogenesis of the traditional Chinese medicine(TCM)syndrome.

Toughening of vinyl ester resins by two-dimensional MXene nanosheets

Two-dimensional nanosheets are highly effective tougheners for vinyl ester resins.The toughening effect is related to the high specific surface area and unique two-dimensional planar structure of the nanosheets.In this study,a coupling agentγ-(2,3-epoxypropoxy)propytrimethoxysilane(Kh-560)was used to modify MXene nanosheets(M-MXene)for use in toughening vinyl ester resin.The mechanical properties,including the tensile strength,flexural strength,Young’s modulus and elongation,of neat vinyl ester resin and vinyl ester resin modified with MXene and M-MXene were investigated.The results showed that modification significantly improved the mechanical properties of the vinyl ester resin.The tensile and flexural strengths of the MXene-nanosheet-modified vinyl ester resin were 27.20%and 25.32%higher,respectively,than those of the neat vinyl ester resin.The coupling agent improved the interfacial compatibility between the MXene nanosheets and vinyl ester resin,which resulted in the tensile and flexural strengths of the M-MXene-nanosheet-modified vinyl ester resin being 52.57%and 54.60%higher,respectively,than those of the neat vinyl ester resin for a loading quantity of nanosheets of only 0.04 wt%,which is economically viable.The main mechanisms by which the nanosheets toughen the resin are crack deflection and crack pinning.