Research reactors with neutron fluxes higher than 10^(14) n cm^(−2) s^(−1) are widely used in nuclear fuel and material irradiation,neutron-based scientific research,and medical and industrial isotope production.Such ...Research reactors with neutron fluxes higher than 10^(14) n cm^(−2) s^(−1) are widely used in nuclear fuel and material irradiation,neutron-based scientific research,and medical and industrial isotope production.Such high flux research reactors are not only important scientific research facilities for the development of nuclear energy but also represent the national comprehensive technical capability.China has several high flux research reactors that do not satisfy the requirements of nuclear energy development.A high flux research reactor has the following features:a compact core arrangement,high power density,plate-type fuel elements,a short refueling cycle,and high coolant velocity in the core.These characteristics make it difficult to simultaneously realize high neutron flux and optimal safety margin.A new multi-mission high flux research reactor was designed by the Institute of Nuclear and New Energy Technology at Tsinghua University in China;the reactor can simul-taneously realize an average neutron flux higher than 2.0×10^(15) n cm^(−2) s^(−1) and fulfill the current safety criterion.This high flux research reactor features advanced design concepts and has sufficient safety margins according to the preliminary safety analysis.Based on the analysis of the station blackout accident,loss of coolant accident,and reactivity accident of a single-control drum rotating out accidently,the maximum temperature of the cladding surface,minimum departure from nucleate boiling ratio,and temperature difference to the onset of nucleate boiling temperature satisfy the design limits.展开更多
AIM: To study the effects of Pinus massoniana bark extract (PMBE) on cell proliferation and apoptosis of human hepatoma BEL-7402 cells and to elucidate its molecular mechanism.METHODS: BEL-7402 cells were incubated wi...AIM: To study the effects of Pinus massoniana bark extract (PMBE) on cell proliferation and apoptosis of human hepatoma BEL-7402 cells and to elucidate its molecular mechanism.METHODS: BEL-7402 cells were incubated with various concentrations (20-200 μg/mL) of PMBE for different periods of time. After 48 h, cell proliferation was determined by 3-(4,5-dimethyl-thiazolyl-2)-2,5-diphenyl tetrazolium bromide (MTT) assay. Apoptosis was evaluated by morphological observation, agarose gel electrophoresis,and flow cytometry analysis. Possible molecular mechanisms were primarily explored through immunohistochemical staining.RESULTS: PMBE (20-200 μg/mL) significantly suppressed BEL-7402 cell proliferation in a time- and dose-dependent manner. After treatment of BEL-7402 cells with 160 μg/mL PMBE for 24, 48, or 72 h, a typical apoptotic 'DNA ladder'was observed using agarose gel electrophoresis. Nuclear condensation and boundary aggregation or split, apoptotic bodies were seen by fluorescence and electron microscopy.Sub-G1 curves were displayed by flow cytometry analysis.PMBE decreased the expression levels of Bcl-2 protein in a time-dependent manner after treatment of cells with 160 μg/mL PMBE.CONCLUSION: PMBE suppresses proliferation of BEL-7402 cells in a time- and dose-dependent manner and induces cell apoptosis by possibly downregulating the expression of the bcl-2 gene.展开更多
The fore claws of the nymph of Cryptotympana atrata have excellent ability to cut and dig soil. Inspired by this, we designed a biomimetic stubble cutter to reduce the cutting resistance. Reverse engineering and 3D pr...The fore claws of the nymph of Cryptotympana atrata have excellent ability to cut and dig soil. Inspired by this, we designed a biomimetic stubble cutter to reduce the cutting resistance. Reverse engineering and 3D print technology were applied to design the biomimetic stubble cutter. Two types of biomimetic corn stubble cutters with different tooth heights （5 mm and 2.5 mm） were designed. The cutting ability of biomimetic corn stubble cutters was compared to the conventional design by the quadratic regression orthogonal test. Tooth height, dip angle of cutting edge, and cutting velocity were chosen as orthogonal test factors. The biomimetic stubble cutters show lower cutting resistance than the conventional one. Cutting velocity exerts the least effect on cutting resistance, followed by tooth height and dip angle of cutting edge. Optimal combination with the least cutting resistance is tooth height of 2.5 mm and dip angle of cutting edge of 40° while the cutting resistance does not vary remarkably with cutting velocity. Test results indicate the serrated structure design as a principal factor for cutting resistance reduction. The biomimetic stubble cutter design, inspired by the soil-cutting mechanism of Cryptotympana atrata nymph, remarkably improves the performance of stubble cutter.展开更多
The resistance between mud surface and ship-type paddy field machine hull accounts for a certain proportion of the total mechanical power consumption during the operation process.The special characteristic has been fo...The resistance between mud surface and ship-type paddy field machine hull accounts for a certain proportion of the total mechanical power consumption during the operation process.The special characteristic has been found via preliminary study,it showed that when starting or working at low velocity,the resistance is much greater than the machine working at the rated velocity.This characteristic affects the dynamic matching and structural design of the machine.The critical velocity of resistance distortion was around 0.025 m/s under the setting experimental conditions,and the mechanism of resistance distortion under multi-medium was analyzed.Based on water film drag reduction theory,a macroscopic structure of crocodile's abdominal armor biomimetic drag reduction method was proposed.Two kinds of bionic macroscopic structure ship board were fabricated.The macroscopic structure can introduce more water into the bottom surface of the hull;thicken the water film,which can reduce the travel resistance.Design and manufacture a ship-type paddy field experimental setup with velocity control,and compare the traditional smooth surface ship board with the two bionic macroscopic structure surfaces through orthogonal test.The experiment results demonstrated that the ship board with rectangle gully structure has better drag reduction effect than the hexagon one in the lower velocity.But when the travel velocity approach to the resistance distortion critical point,the hexagon gully structure become better than the other one.Through the orthogonal test,the best drag reduction combination is 2.5 kg load weight,0.025 m/s travel velocity with hexagon ship board,which decreases the drag by 6.3%.展开更多
Gradient wettability is important for some living organisms.Herein,the dynamic responses of water droplets impacting on the surfaces of four regions along the wing vein of cicada Cryptotympana atratafabricius are inve...Gradient wettability is important for some living organisms.Herein,the dynamic responses of water droplets impacting on the surfaces of four regions along the wing vein of cicada Cryptotympana atratafabricius are investigated.It is revealed that a gradient wetting behavior from hydrophilicity(the Wenzel state)to hydrophobicity and further to superhydrophobicity(the Cassie-Baxter state)appears from the foot to apex of the wing.Water droplets impacting on the hydrophilic region of the wing cannot rebound,whereas those impacting on the hydrophobic region can retract and completely rebound.The hydrophobic region exhibits robust water-repelling performance during the dynamic droplet impact.Moreover,a droplet sitting on the hydrophobic region can recover its spherical shape after squeezed to a water film as thin as 0.45 mm,and lossless droplet transportation can be achieved at the region.Based on the geometric parameters of the nanopillars at the hydrophilic and hydrophobic regions on the cicada wing,two wetting models are developed for elucidating the mechanism for the gradient wetting behavior.This work directs the design and fabrication of surfaces with gradient wetting behavior by mimicking the nanopillars on cicada wing surface.展开更多
文摘Research reactors with neutron fluxes higher than 10^(14) n cm^(−2) s^(−1) are widely used in nuclear fuel and material irradiation,neutron-based scientific research,and medical and industrial isotope production.Such high flux research reactors are not only important scientific research facilities for the development of nuclear energy but also represent the national comprehensive technical capability.China has several high flux research reactors that do not satisfy the requirements of nuclear energy development.A high flux research reactor has the following features:a compact core arrangement,high power density,plate-type fuel elements,a short refueling cycle,and high coolant velocity in the core.These characteristics make it difficult to simultaneously realize high neutron flux and optimal safety margin.A new multi-mission high flux research reactor was designed by the Institute of Nuclear and New Energy Technology at Tsinghua University in China;the reactor can simul-taneously realize an average neutron flux higher than 2.0×10^(15) n cm^(−2) s^(−1) and fulfill the current safety criterion.This high flux research reactor features advanced design concepts and has sufficient safety margins according to the preliminary safety analysis.Based on the analysis of the station blackout accident,loss of coolant accident,and reactivity accident of a single-control drum rotating out accidently,the maximum temperature of the cladding surface,minimum departure from nucleate boiling ratio,and temperature difference to the onset of nucleate boiling temperature satisfy the design limits.
文摘AIM: To study the effects of Pinus massoniana bark extract (PMBE) on cell proliferation and apoptosis of human hepatoma BEL-7402 cells and to elucidate its molecular mechanism.METHODS: BEL-7402 cells were incubated with various concentrations (20-200 μg/mL) of PMBE for different periods of time. After 48 h, cell proliferation was determined by 3-(4,5-dimethyl-thiazolyl-2)-2,5-diphenyl tetrazolium bromide (MTT) assay. Apoptosis was evaluated by morphological observation, agarose gel electrophoresis,and flow cytometry analysis. Possible molecular mechanisms were primarily explored through immunohistochemical staining.RESULTS: PMBE (20-200 μg/mL) significantly suppressed BEL-7402 cell proliferation in a time- and dose-dependent manner. After treatment of BEL-7402 cells with 160 μg/mL PMBE for 24, 48, or 72 h, a typical apoptotic 'DNA ladder'was observed using agarose gel electrophoresis. Nuclear condensation and boundary aggregation or split, apoptotic bodies were seen by fluorescence and electron microscopy.Sub-G1 curves were displayed by flow cytometry analysis.PMBE decreased the expression levels of Bcl-2 protein in a time-dependent manner after treatment of cells with 160 μg/mL PMBE.CONCLUSION: PMBE suppresses proliferation of BEL-7402 cells in a time- and dose-dependent manner and induces cell apoptosis by possibly downregulating the expression of the bcl-2 gene.
文摘The fore claws of the nymph of Cryptotympana atrata have excellent ability to cut and dig soil. Inspired by this, we designed a biomimetic stubble cutter to reduce the cutting resistance. Reverse engineering and 3D print technology were applied to design the biomimetic stubble cutter. Two types of biomimetic corn stubble cutters with different tooth heights （5 mm and 2.5 mm） were designed. The cutting ability of biomimetic corn stubble cutters was compared to the conventional design by the quadratic regression orthogonal test. Tooth height, dip angle of cutting edge, and cutting velocity were chosen as orthogonal test factors. The biomimetic stubble cutters show lower cutting resistance than the conventional one. Cutting velocity exerts the least effect on cutting resistance, followed by tooth height and dip angle of cutting edge. Optimal combination with the least cutting resistance is tooth height of 2.5 mm and dip angle of cutting edge of 40° while the cutting resistance does not vary remarkably with cutting velocity. Test results indicate the serrated structure design as a principal factor for cutting resistance reduction. The biomimetic stubble cutter design, inspired by the soil-cutting mechanism of Cryptotympana atrata nymph, remarkably improves the performance of stubble cutter.
基金The authors gratefully acknowledge the financial support of Guangdong Provincial Special Fund for Modern Agriculture Industry Technology Innovation Teams under Grants No.2019KJ125the fund of Young Innovative Talents Project from Department of Education of Guangdong Province China(Grants No.2018KQNCX021).
文摘The resistance between mud surface and ship-type paddy field machine hull accounts for a certain proportion of the total mechanical power consumption during the operation process.The special characteristic has been found via preliminary study,it showed that when starting or working at low velocity,the resistance is much greater than the machine working at the rated velocity.This characteristic affects the dynamic matching and structural design of the machine.The critical velocity of resistance distortion was around 0.025 m/s under the setting experimental conditions,and the mechanism of resistance distortion under multi-medium was analyzed.Based on water film drag reduction theory,a macroscopic structure of crocodile's abdominal armor biomimetic drag reduction method was proposed.Two kinds of bionic macroscopic structure ship board were fabricated.The macroscopic structure can introduce more water into the bottom surface of the hull;thicken the water film,which can reduce the travel resistance.Design and manufacture a ship-type paddy field experimental setup with velocity control,and compare the traditional smooth surface ship board with the two bionic macroscopic structure surfaces through orthogonal test.The experiment results demonstrated that the ship board with rectangle gully structure has better drag reduction effect than the hexagon one in the lower velocity.But when the travel velocity approach to the resistance distortion critical point,the hexagon gully structure become better than the other one.Through the orthogonal test,the best drag reduction combination is 2.5 kg load weight,0.025 m/s travel velocity with hexagon ship board,which decreases the drag by 6.3%.
基金Financial support provided by the National Natural Science Foundation of China(Grant No.51533003)the Natural Science Foundation of Guangdong Province(Grant No.2016A030308018)+1 种基金the Guangzhou Municipal Science and Technology Project(Grant No.201807010088)the Opening Project(KFKT1805)of Key Laboratory of Polymer Processing Engineering(Ministry of Education)are gratefully acknowledged.
文摘Gradient wettability is important for some living organisms.Herein,the dynamic responses of water droplets impacting on the surfaces of four regions along the wing vein of cicada Cryptotympana atratafabricius are investigated.It is revealed that a gradient wetting behavior from hydrophilicity(the Wenzel state)to hydrophobicity and further to superhydrophobicity(the Cassie-Baxter state)appears from the foot to apex of the wing.Water droplets impacting on the hydrophilic region of the wing cannot rebound,whereas those impacting on the hydrophobic region can retract and completely rebound.The hydrophobic region exhibits robust water-repelling performance during the dynamic droplet impact.Moreover,a droplet sitting on the hydrophobic region can recover its spherical shape after squeezed to a water film as thin as 0.45 mm,and lossless droplet transportation can be achieved at the region.Based on the geometric parameters of the nanopillars at the hydrophilic and hydrophobic regions on the cicada wing,two wetting models are developed for elucidating the mechanism for the gradient wetting behavior.This work directs the design and fabrication of surfaces with gradient wetting behavior by mimicking the nanopillars on cicada wing surface.
