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Electrostatic assembly functionalization of poly(γ-glutamic acid)for biomedical antibacterial applications 被引量:1
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作者 Xiaodan Wang hengchong shi +5 位作者 Haoyu Tang Huan Yu Qiuyan Yan Huawei Yang Xu Zhang shifang Luan 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2020年第24期14-25,共12页
Poly(γ-glutamic acid)(γ-PGA)has been found widespread applications in biomedical field because of its excellent water solubility,biocompatibility,and bioactivity.Herein,a water-insoluble γ-PGA antibacterial compoun... Poly(γ-glutamic acid)(γ-PGA)has been found widespread applications in biomedical field because of its excellent water solubility,biocompatibility,and bioactivity.Herein,a water-insoluble γ-PGA antibacterial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate(ELA).The functionalized γ-PGA compound(γ-PGA-ELA)ethanol solution can facilely produce colorless and transparent coatings on various inorganic,metal,and polymeric substrates,especially for the lumen of slender catheters(length up to 2 m,and inner diameter down to 1 mm).The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo.In addition,the γ-PGA compound is used as antibacterial additives of polyolefin via melting extrusion,and the asprepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy.More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility,low cytotoxicity,and satisfactory histocompatibility.The as-proposed γ-PGA compound has a great potential to serve as a safe and multifunctional antibacterial candidate to combat biomedical devices-related infections. 展开更多
关键词 Functionalized poly(γ-glutamic acid)compound Electrostatic assembly Antibacterial coating Antibacterial additive Catheter-associated infections
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