An increasing number of studies are suggesting that hepatitis B virus(HBV)infection may be associated with an increased risk of not only hepatocellular carcinoma but also gastric cancer(GC).Whether HBV infection can b...An increasing number of studies are suggesting that hepatitis B virus(HBV)infection may be associated with an increased risk of not only hepatocellular carcinoma but also gastric cancer(GC).Whether HBV infection can be a risk factor for GC remains to be explored.In this study,we systematically searched for all eligible literature in 7 databases(China National Knowledge Infrastructure,WanFang,China Science and Technology Journal,PubMed,Cochrane Library,Web of Science and Embase).Eligible studies were required to have a case-control or cohort design.Sixteen studies were included and a meta-analysis was performed using Stata version 17.0.The quality of the included studies was assessed using the Newcastle-Ottawa Scale.The association between HBV infection and risk of GC was quantified by calculating the odds ratio and 95%confidence interval.The proportion of high-quality studies was 87.5%(14/16).The risk of GC was higher when HBV infection was present than when it was not(combined odds ratio 1.29,95%confidence interval 1.16-1.44;I^(2)=62.7%,p<0.001).The results of subgroup analyses were consistent with the main results.In conclusion,this systematic review and meta-analysis identified a positive association between HBV infection and an increased risk of GC.展开更多
Background Iron overload is frequently observed in non-alcoholic fatty liver disease(NAFLD).Transferrin receptor 2(TFR2)is an important key factor in iron regulation.We aimed to investigate whether TFR2 single nucleot...Background Iron overload is frequently observed in non-alcoholic fatty liver disease(NAFLD).Transferrin receptor 2(TFR2)is an important key factor in iron regulation.We aimed to investigate whether TFR2 single nucleotide polymorphisms(SNPs)contribute to susceptibility to NAFLD in a Chinese Han population.Methods Five tag SNPs(rs10247962,rs4434553,rs2075672,rs1052897,and rs3757859)in the TFR2 gene were selected and genotyped in a case–control study on participants who visited two affiliated hospitals of Fujian Medical University between June 2011 and August 2017.Propensity score matching and inverse probability of treatment weighting analyses were used to verify the risk associated with TFR2 SNPs.Results Logistic regression analyses suggested that subjects with the rs4434553 GA or GG genotype had a lower risk of NAFLD than those carrying the AA genotype(odds ratio=0.630,95%confidence interval=0.504–0.788).Moreover,the rs4434553 GA or GG genotype was negatively correlated with body mass index,hepatic steatosis index,and serum ferritin(b=-0.363,P=0.008;b=-1.040,P=0.009;b=-35.258,P=0.015,respectively),and positively associated with serum hepcidin level(b=35.308,P<0.001).Moreover,rs10247962 and rs1052897 had multiplicative interactions with age in relation to the risk of NAFLD(P for interactions,0.041 and 0.034,respectively).The cumulative effects of the rs10247962,rs1052897,and rs4434553 SNPs were positively associated with the risk of NAFLD(adjusted P_(trend)=0.012).Conclusions In this Chinese Han population,the rs4434553 polymorphism in TFR2 may be an independent influencing factor associated with the susceptibility to NAFLD.The ageing effect on the development of NAFLD may be inhibited by SNPs rs10247962 and rs1052897.展开更多
文摘An increasing number of studies are suggesting that hepatitis B virus(HBV)infection may be associated with an increased risk of not only hepatocellular carcinoma but also gastric cancer(GC).Whether HBV infection can be a risk factor for GC remains to be explored.In this study,we systematically searched for all eligible literature in 7 databases(China National Knowledge Infrastructure,WanFang,China Science and Technology Journal,PubMed,Cochrane Library,Web of Science and Embase).Eligible studies were required to have a case-control or cohort design.Sixteen studies were included and a meta-analysis was performed using Stata version 17.0.The quality of the included studies was assessed using the Newcastle-Ottawa Scale.The association between HBV infection and risk of GC was quantified by calculating the odds ratio and 95%confidence interval.The proportion of high-quality studies was 87.5%(14/16).The risk of GC was higher when HBV infection was present than when it was not(combined odds ratio 1.29,95%confidence interval 1.16-1.44;I^(2)=62.7%,p<0.001).The results of subgroup analyses were consistent with the main results.In conclusion,this systematic review and meta-analysis identified a positive association between HBV infection and an increased risk of GC.
基金supported by the National Natural Science Foundation of China[grant number 81473047]the Natural Science Foundation of Fujian Province[grant number 2019J01316].
文摘Background Iron overload is frequently observed in non-alcoholic fatty liver disease(NAFLD).Transferrin receptor 2(TFR2)is an important key factor in iron regulation.We aimed to investigate whether TFR2 single nucleotide polymorphisms(SNPs)contribute to susceptibility to NAFLD in a Chinese Han population.Methods Five tag SNPs(rs10247962,rs4434553,rs2075672,rs1052897,and rs3757859)in the TFR2 gene were selected and genotyped in a case–control study on participants who visited two affiliated hospitals of Fujian Medical University between June 2011 and August 2017.Propensity score matching and inverse probability of treatment weighting analyses were used to verify the risk associated with TFR2 SNPs.Results Logistic regression analyses suggested that subjects with the rs4434553 GA or GG genotype had a lower risk of NAFLD than those carrying the AA genotype(odds ratio=0.630,95%confidence interval=0.504–0.788).Moreover,the rs4434553 GA or GG genotype was negatively correlated with body mass index,hepatic steatosis index,and serum ferritin(b=-0.363,P=0.008;b=-1.040,P=0.009;b=-35.258,P=0.015,respectively),and positively associated with serum hepcidin level(b=35.308,P<0.001).Moreover,rs10247962 and rs1052897 had multiplicative interactions with age in relation to the risk of NAFLD(P for interactions,0.041 and 0.034,respectively).The cumulative effects of the rs10247962,rs1052897,and rs4434553 SNPs were positively associated with the risk of NAFLD(adjusted P_(trend)=0.012).Conclusions In this Chinese Han population,the rs4434553 polymorphism in TFR2 may be an independent influencing factor associated with the susceptibility to NAFLD.The ageing effect on the development of NAFLD may be inhibited by SNPs rs10247962 and rs1052897.
