Neurothekeomas are benign tumors probably of nerve sheath origin and are also known as dermal nerve sheath myxomas. They are commonly found on the face, arm, or shoulder and less frequently the lower limbs. To our kno...Neurothekeomas are benign tumors probably of nerve sheath origin and are also known as dermal nerve sheath myxomas. They are commonly found on the face, arm, or shoulder and less frequently the lower limbs. To our knowledge, this is the first case of a subungual neurothekeoma affecting the big toe. Histology confirmed a well- circumscribed, multilobulated tumor composed of bland stellate and spindle cells in a copious myxoid matrix staining positive with S100 protein.展开更多
Three children with severe atopic dermatitis were noted at routine follow- up to have developed multiple small pigmented macules during long- term therapy with topical tacrolimus 0.1% (Protopic., Fujisawa). Representa...Three children with severe atopic dermatitis were noted at routine follow- up to have developed multiple small pigmented macules during long- term therapy with topical tacrolimus 0.1% (Protopic., Fujisawa). Representative lesions in two of the three cases were confirmed histologically as simple lentigines. The focal distribution of lentigines to sites of tacrolimus use, and the temporal association between use of tacrolimus and development of lesions, suggest that topical tacrolimus is of direct aetiological relevance to their development. Careful long-term follow-up will be required to assess the clinical implications of these findings and whether they represent an increase in risk for melanocytic neoplasia.展开更多
文摘Neurothekeomas are benign tumors probably of nerve sheath origin and are also known as dermal nerve sheath myxomas. They are commonly found on the face, arm, or shoulder and less frequently the lower limbs. To our knowledge, this is the first case of a subungual neurothekeoma affecting the big toe. Histology confirmed a well- circumscribed, multilobulated tumor composed of bland stellate and spindle cells in a copious myxoid matrix staining positive with S100 protein.
文摘Three children with severe atopic dermatitis were noted at routine follow- up to have developed multiple small pigmented macules during long- term therapy with topical tacrolimus 0.1% (Protopic., Fujisawa). Representative lesions in two of the three cases were confirmed histologically as simple lentigines. The focal distribution of lentigines to sites of tacrolimus use, and the temporal association between use of tacrolimus and development of lesions, suggest that topical tacrolimus is of direct aetiological relevance to their development. Careful long-term follow-up will be required to assess the clinical implications of these findings and whether they represent an increase in risk for melanocytic neoplasia.
