The treatment of atrophoderma vermiculatum is challenging. A 7-year-old girl had a unilateral atrophic skin lesion on her right cheek, which was diagnosed as unilateral atrophoderma vermiculata. She was treated by car...The treatment of atrophoderma vermiculatum is challenging. A 7-year-old girl had a unilateral atrophic skin lesion on her right cheek, which was diagnosed as unilateral atrophoderma vermiculata. She was treated by carbon dioxide and 595 nm pulsed dye laser and carbon dioxide laser. This resulted in prevention of the lesional progression with favorable cosmetic appearance of the skin.展开更多
This paper describes a theoretical estimation of the geometry of negative epoxy-resist microneedles prepared via inclined/rotated ultraviolet(UV)lithography based on spatially controlled UV exposure doses.In compariso...This paper describes a theoretical estimation of the geometry of negative epoxy-resist microneedles prepared via inclined/rotated ultraviolet(UV)lithography based on spatially controlled UV exposure doses.In comparison with other methods based on UV lithography,the present method can create microneedle structures with high scalability.When negative photoresist is exposed to inclined/rotated UV through circular mask patterns,a three-dimensional,needle-shaped distribution of the exposure dose forms in the irradiated region.Controlling the inclination angles and the exposure dose modifies the photo-polymerized portion of the photoresist,thus allowing the variation of the heights and contours of microneedles formed by using the same mask patterns.In an experimental study,the dimensions of the fabricated needles agreed well with the theoretical predictions for varying inclination angles and exposure doses.These results demonstrate that our theoretical approach can provide a simple route for fabricating microneedles with on-demand geometry.The fabricated microneedles can be used as solid microneedles or as a mold master for dissolving microneedles,thus simplifying the microneedle fabrication process.We envision that this method can improve fabrication accuracy and reduce fabrication cost and time,thereby facilitating the practical applications of microneedle-based drug delivery technology.展开更多
文摘The treatment of atrophoderma vermiculatum is challenging. A 7-year-old girl had a unilateral atrophic skin lesion on her right cheek, which was diagnosed as unilateral atrophoderma vermiculata. She was treated by carbon dioxide and 595 nm pulsed dye laser and carbon dioxide laser. This resulted in prevention of the lesional progression with favorable cosmetic appearance of the skin.
基金This work was partially supported by Japan Science Technology Agency,Izumi Science and Technology Foundation,the Tateisi Science and Technology Foundation,and the Mazda Foundation
文摘This paper describes a theoretical estimation of the geometry of negative epoxy-resist microneedles prepared via inclined/rotated ultraviolet(UV)lithography based on spatially controlled UV exposure doses.In comparison with other methods based on UV lithography,the present method can create microneedle structures with high scalability.When negative photoresist is exposed to inclined/rotated UV through circular mask patterns,a three-dimensional,needle-shaped distribution of the exposure dose forms in the irradiated region.Controlling the inclination angles and the exposure dose modifies the photo-polymerized portion of the photoresist,thus allowing the variation of the heights and contours of microneedles formed by using the same mask patterns.In an experimental study,the dimensions of the fabricated needles agreed well with the theoretical predictions for varying inclination angles and exposure doses.These results demonstrate that our theoretical approach can provide a simple route for fabricating microneedles with on-demand geometry.The fabricated microneedles can be used as solid microneedles or as a mold master for dissolving microneedles,thus simplifying the microneedle fabrication process.We envision that this method can improve fabrication accuracy and reduce fabrication cost and time,thereby facilitating the practical applications of microneedle-based drug delivery technology.
