Interleukin-12, a heterodimer produced mainlyby antigen presenting cells (APCs), plays vital rolesin the induction of Thl-mediated immune responsesand has the potential to treat cancer and infectiousdiseases. Systemic...Interleukin-12, a heterodimer produced mainlyby antigen presenting cells (APCs), plays vital rolesin the induction of Thl-mediated immune responsesand has the potential to treat cancer and infectiousdiseases. Systemic administration of IL-12 wasobserved to be associated with severe toxicity. To takefull advantage of its immunoregulatory activities andminimize its toxicities, local administration of IL-12may be the ideal approach. Intratumoral injection展开更多
Dendritic cells (DC) play a critical role in theinduction of immune responses, and are utilized as potentadjuvants in cancer immunotherapy. Several strategies forloading DC with tumor antigens have been developed.Vacc...Dendritic cells (DC) play a critical role in theinduction of immune responses, and are utilized as potentadjuvants in cancer immunotherapy. Several strategies forloading DC with tumor antigens have been developed.Vaccination with tumor antigen-loaded DC wasdemonstrated to be capable of inducing antitumorimmunity, but some limitations still exist. So展开更多
Hepatocellular carcinoma (HCC) is one of the mostcommon cancers in the world, especially in East Asia.There is no standardized or effective strategy could beadapted routinely except of some early diagnosedpatients, an...Hepatocellular carcinoma (HCC) is one of the mostcommon cancers in the world, especially in East Asia.There is no standardized or effective strategy could beadapted routinely except of some early diagnosedpatients, and the prognosis is poor. In recent years, genetherapy has become a standard experimental approach fortreating cancers that have escaped conventionaltherapies. One such an approach is to confer the tumorcells with sensitivity to chemical reagents through展开更多
Interleukin-2(IL-2) has been demonstrated to beone of the most effective target genes in cancerimmunogene therapy. There are more than 20 clinicalprotocols of cancer gene therapy introducing IL-2 intotumor patients to...Interleukin-2(IL-2) has been demonstrated to beone of the most effective target genes in cancerimmunogene therapy. There are more than 20 clinicalprotocols of cancer gene therapy introducing IL-2 intotumor patients to treat melanoma, renal carcinoma,prostate carcinoma, colon carcinoma,展开更多
Granulocyte/macrophage colony-stimulatingfactor (GM-CSF) plays important roles in theregulation of hematogenesis and the immuneresponses. Vaccination with GM-CSF gene-modifiedtumor cells was demonstrated to be capable...Granulocyte/macrophage colony-stimulatingfactor (GM-CSF) plays important roles in theregulation of hematogenesis and the immuneresponses. Vaccination with GM-CSF gene-modifiedtumor cells was demonstrated to be capable ofinducing long-lasting, effective and specific antitumorimmune reaction. This protocol has entered展开更多
Background Our previous studies have demonstrated potent oncolysis efficacy of the E1A, E1B double-restricted replication-competent oncolytic adenovirus AxdAdB-3 for treatment of bladder cancer. Here, we reported the ...Background Our previous studies have demonstrated potent oncolysis efficacy of the E1A, E1B double-restricted replication-competent oncolytic adenovirus AxdAdB-3 for treatment of bladder cancer. Here, we reported the feasibility and efficacy of AxdAdB-3 alone, or in combination with gemcitabine for treating renal cell carcinoma.展开更多
Purpose:This article examines the Japanese teaching profession’s position on current school governance reforms in Japan and the difficulties teachers are facing as the reforms progress.Design/Approach/Methods:This ar...Purpose:This article examines the Japanese teaching profession’s position on current school governance reforms in Japan and the difficulties teachers are facing as the reforms progress.Design/Approach/Methods:This article describes how a policy for developing teacher quality standards tends to suppress teacher independence while increasing the heteronomy of the teaching profession.The article discusses how Japan can meet its goal of ensuring“expertise in the teaching profession”by referring to the relationship between“professionalism”and“publicness”in the theories of occupational sociology.Findings:Expertise in the teaching profession is based on a mixture of academic and practical knowledge.The term“educational professionals”should be interpreted to include both“researchers”and“practitioners.”A sustainable governance mechanism for the Japanese teaching profession should be built on a four-way relationship among researchers,practitioners,citizens,and government administrators.Originality/Value:This study provides a critical review of a broad-reaching educational policy and proposes a new approach for restructuring the governance of the Japanese teaching profession.展开更多
文摘Interleukin-12, a heterodimer produced mainlyby antigen presenting cells (APCs), plays vital rolesin the induction of Thl-mediated immune responsesand has the potential to treat cancer and infectiousdiseases. Systemic administration of IL-12 wasobserved to be associated with severe toxicity. To takefull advantage of its immunoregulatory activities andminimize its toxicities, local administration of IL-12may be the ideal approach. Intratumoral injection
文摘Dendritic cells (DC) play a critical role in theinduction of immune responses, and are utilized as potentadjuvants in cancer immunotherapy. Several strategies forloading DC with tumor antigens have been developed.Vaccination with tumor antigen-loaded DC wasdemonstrated to be capable of inducing antitumorimmunity, but some limitations still exist. So
文摘Hepatocellular carcinoma (HCC) is one of the mostcommon cancers in the world, especially in East Asia.There is no standardized or effective strategy could beadapted routinely except of some early diagnosedpatients, and the prognosis is poor. In recent years, genetherapy has become a standard experimental approach fortreating cancers that have escaped conventionaltherapies. One such an approach is to confer the tumorcells with sensitivity to chemical reagents through
文摘Interleukin-2(IL-2) has been demonstrated to beone of the most effective target genes in cancerimmunogene therapy. There are more than 20 clinicalprotocols of cancer gene therapy introducing IL-2 intotumor patients to treat melanoma, renal carcinoma,prostate carcinoma, colon carcinoma,
文摘Granulocyte/macrophage colony-stimulatingfactor (GM-CSF) plays important roles in theregulation of hematogenesis and the immuneresponses. Vaccination with GM-CSF gene-modifiedtumor cells was demonstrated to be capable ofinducing long-lasting, effective and specific antitumorimmune reaction. This protocol has entered
文摘Background Our previous studies have demonstrated potent oncolysis efficacy of the E1A, E1B double-restricted replication-competent oncolytic adenovirus AxdAdB-3 for treatment of bladder cancer. Here, we reported the feasibility and efficacy of AxdAdB-3 alone, or in combination with gemcitabine for treating renal cell carcinoma.
基金The author(s)disclosed receipt of the following financial support for the research,authorship,and/or publication of this article:This work was supported by JSPS KAKENHI under grant number JP15K13172.
文摘Purpose:This article examines the Japanese teaching profession’s position on current school governance reforms in Japan and the difficulties teachers are facing as the reforms progress.Design/Approach/Methods:This article describes how a policy for developing teacher quality standards tends to suppress teacher independence while increasing the heteronomy of the teaching profession.The article discusses how Japan can meet its goal of ensuring“expertise in the teaching profession”by referring to the relationship between“professionalism”and“publicness”in the theories of occupational sociology.Findings:Expertise in the teaching profession is based on a mixture of academic and practical knowledge.The term“educational professionals”should be interpreted to include both“researchers”and“practitioners.”A sustainable governance mechanism for the Japanese teaching profession should be built on a four-way relationship among researchers,practitioners,citizens,and government administrators.Originality/Value:This study provides a critical review of a broad-reaching educational policy and proposes a new approach for restructuring the governance of the Japanese teaching profession.
