TWIK-related acid-sensitive K+(TASK) channels give rise to leak K+ currents which influence the resting membrane potential and input resistance. The wide expression of TASK1 and TASK3 channels in the central nervous s...TWIK-related acid-sensitive K+(TASK) channels give rise to leak K+ currents which influence the resting membrane potential and input resistance. The wide expression of TASK1 and TASK3 channels in the central nervous system suggests that these channels are critically involved in neurological disorders. It has become apparent in the past decade that TASK channels play critical roles for the development of various neurological disorders. In this review, I describe evidence for their roles in ischemia, epilepsy, learning/memory/cognition and apoptosis.展开更多
The cumulative evidence from animal and human studies revealed that the anterior cingulate cortex (ACC) plays essential roles in pain sensation and persistent pain. It has been evident in the ACC synapses of animals t...The cumulative evidence from animal and human studies revealed that the anterior cingulate cortex (ACC) plays essential roles in pain sensation and persistent pain. It has been evident in the ACC synapses of animals that changes in both the presynaptic and postsynaptic function are caused by peripheral nerve injury. Thus far, postsynaptic changes in the ACC following nerve injury have been primarily studied to understand the mechanisms of chronic pain. In recent years, studies focusing on the presynaptic mechanisms in chronic pain have been progressively increased. In this review, I will discuss molecular mechanisms associated with chronic pain and presynaptic form of long-term potentiation. I will also discuss evidence for presynaptic changes in the ACC caused by disease-related pain.展开更多
文摘TWIK-related acid-sensitive K+(TASK) channels give rise to leak K+ currents which influence the resting membrane potential and input resistance. The wide expression of TASK1 and TASK3 channels in the central nervous system suggests that these channels are critically involved in neurological disorders. It has become apparent in the past decade that TASK channels play critical roles for the development of various neurological disorders. In this review, I describe evidence for their roles in ischemia, epilepsy, learning/memory/cognition and apoptosis.
文摘The cumulative evidence from animal and human studies revealed that the anterior cingulate cortex (ACC) plays essential roles in pain sensation and persistent pain. It has been evident in the ACC synapses of animals that changes in both the presynaptic and postsynaptic function are caused by peripheral nerve injury. Thus far, postsynaptic changes in the ACC following nerve injury have been primarily studied to understand the mechanisms of chronic pain. In recent years, studies focusing on the presynaptic mechanisms in chronic pain have been progressively increased. In this review, I will discuss molecular mechanisms associated with chronic pain and presynaptic form of long-term potentiation. I will also discuss evidence for presynaptic changes in the ACC caused by disease-related pain.
