Ghrelin causes interdigestive contractions of the stom- ach in rats. However, it remains unknown whether ghrelin causes interdigestive contractions in the small intestine. Four strain gauge transducers were implanted ...Ghrelin causes interdigestive contractions of the stom- ach in rats. However, it remains unknown whether ghrelin causes interdigestive contractions in the small intestine. Four strain gauge transducers were implanted on the antrum, duodenum, proximal and distal jejunum. After an overnight fast, gastrointestinal (GI) contrac- tions were recorded in freely moving conscious rats. Spontaneous phase Ⅲ-like contractions were observed at every 13-16 min in rat GI tract. The fasted motor patterns were replaced by the fed motor pattern immediately after food intake. Two minutes after f inishing the spontaneous phase Ⅲ-like contractions in the antrum, acyl ghrelin (0.8, 2.4 and 8.0 μg/kg per min) was con- tinuously infused for 30 min. Three-f ive minutes after the starting ghrelin infusion, augmented phase Ⅲ-like contractions were observed at the antrum, duodenum, and jejunum. Ghrelin infusion (0.8, 2.4 and 8.0 μg/kg per min) signif icantly increased motility index of phase Ⅲ-like contractions at the antrum and jejunum in a dose dependent manner, compared to that of saline in- jection. Thus, it is likely that exogenously administered ghrelin causes phase Ⅲ-like contraction at the antrum, which migrates to the duodenum and jejunum. The possible role of 5-HT, in addition to ghrelin, in mediating intestinal migrating motor complex (MMC), is discussed.展开更多
Objective:To determine the prevalence of hypomagnesemia and the risk of hypomagnesemia on metabolic syndrome and type 2 diabetes mellitus events in native Balinese.Methods:A cross-sectional population-based study was ...Objective:To determine the prevalence of hypomagnesemia and the risk of hypomagnesemia on metabolic syndrome and type 2 diabetes mellitus events in native Balinese.Methods:A cross-sectional population-based study was conducted in 111 subjects among native Balinese.Chi-square test was used to determine the prevalence risk(OR)of hypomagnesemia for metabolic syndrome and diabetes.Results:Prevalence of hypomagnesemia was 17.1%.The prevalence of hypomagnesemia was higher in subjects with metabolic syndrome and type 2 diabetes mellitus than those without(34.7%vs.12.5%,P=0.025;and 60.0%vs.15.1%,P=0.035).Hypomagnesemia was a risk factor for metabolic syndrome(OR=3.7;95%CI,1.28-10.83)and type 2 diabetes mellitus(OR=8.4;95%CI,1.30-54.50).Conclusion:The prevalence of hypomagnesemia is very high among native Balinese and hypomagnesemia is an important risk factor for metabolic syndrome and type 2 diabetes mellitus events in the population.展开更多
文摘Ghrelin causes interdigestive contractions of the stom- ach in rats. However, it remains unknown whether ghrelin causes interdigestive contractions in the small intestine. Four strain gauge transducers were implanted on the antrum, duodenum, proximal and distal jejunum. After an overnight fast, gastrointestinal (GI) contrac- tions were recorded in freely moving conscious rats. Spontaneous phase Ⅲ-like contractions were observed at every 13-16 min in rat GI tract. The fasted motor patterns were replaced by the fed motor pattern immediately after food intake. Two minutes after f inishing the spontaneous phase Ⅲ-like contractions in the antrum, acyl ghrelin (0.8, 2.4 and 8.0 μg/kg per min) was con- tinuously infused for 30 min. Three-f ive minutes after the starting ghrelin infusion, augmented phase Ⅲ-like contractions were observed at the antrum, duodenum, and jejunum. Ghrelin infusion (0.8, 2.4 and 8.0 μg/kg per min) signif icantly increased motility index of phase Ⅲ-like contractions at the antrum and jejunum in a dose dependent manner, compared to that of saline in- jection. Thus, it is likely that exogenously administered ghrelin causes phase Ⅲ-like contraction at the antrum, which migrates to the duodenum and jejunum. The possible role of 5-HT, in addition to ghrelin, in mediating intestinal migrating motor complex (MMC), is discussed.
基金funded by Faculty of Medicine of Udayana University,Denpasar,Bali,IndonesiaIndonesian Society of Endocrinology,Bali Branch+1 种基金Eijkman Institute of Molecular Biology,JakartaKobe Women’s University,Japan.
文摘Objective:To determine the prevalence of hypomagnesemia and the risk of hypomagnesemia on metabolic syndrome and type 2 diabetes mellitus events in native Balinese.Methods:A cross-sectional population-based study was conducted in 111 subjects among native Balinese.Chi-square test was used to determine the prevalence risk(OR)of hypomagnesemia for metabolic syndrome and diabetes.Results:Prevalence of hypomagnesemia was 17.1%.The prevalence of hypomagnesemia was higher in subjects with metabolic syndrome and type 2 diabetes mellitus than those without(34.7%vs.12.5%,P=0.025;and 60.0%vs.15.1%,P=0.035).Hypomagnesemia was a risk factor for metabolic syndrome(OR=3.7;95%CI,1.28-10.83)and type 2 diabetes mellitus(OR=8.4;95%CI,1.30-54.50).Conclusion:The prevalence of hypomagnesemia is very high among native Balinese and hypomagnesemia is an important risk factor for metabolic syndrome and type 2 diabetes mellitus events in the population.
