A Study of Optimum Switching Problem for Production Systems Considering Efficiency, Delivery Time and Green Evaluation

This paper aims to derive the optimal switching strategy for production system considering efficiency, delivery time and green evaluation. Nowadays more and more manufacturing and logistics systems not only pursue better work efficiency, but also focus on green energy evaluation issues. Cost reduction and shortening of delivery time are always important management issues in pursuit of efficiency and optimization of the entire production system because of global production competition. In a market situation where customer needs change in various ways, in particular, due to inadequate quality, changes in the local environment, natural disasters and so on. Therefore, prompt planning of management measures such as switching work processes and changing production methods has become an important issue. On the other hand, since the Paris Agreement came into effect, the construction of an environment-friendly production system has been required as an approach to environmental problems such as global warming. In this paper, we propose an optimum switching model of production systems considering efficiency, delivery time and green evaluation using a green evaluation index (GEC: Green Energy Coefficient). We also discuss the optimal switching strategy by numerical observation.

An Unusual Acceleration of Amination Reactivity by the Proximal Ester Groups in Catechol Diesters: An Efficient Way for Peptide Synthesis

Peptide bond formation has drawn more and more attention due to its importance in medicinal chemistry and drug discovery.Using active esters to construct peptide bonds is an indispensable strategy in this field.We herein report a fast and efficient amination reaction to synthesize peptides from catechol diesters.Catechol monoesters are good active esters in peptide synthesis due to the anchimeric assistance effect.In previously reported work,the amination reaction was inactivated if the 2-hydroxyl group in the catechol esters was functionalized.However,we found an unusual acceleration of the amination reactivity when the 2-hydroxyl group was functionalized as an ester group.The reaction can be complete in 2−3 min in some cases.This acceleration was found through experimental studies to not result from the anchimeric assistance effect.We proposed aπ*−π*interaction pathway between the two proximal ester groups.Some computational studies were made to support this assumption.

A study of optimal switching problem in limited-cycle with multiple periods

In a social system or production line,the restrictions of the cost and the due-time exist in each period.Generally,whether these restrictions are satisfied is dependent not only on the risks of this period,but also on the risks generated beforehand.We consider controlling the production process by switching the processing rate to a faster one at a given period.This paper deals with the optimal switching period to minimize the total expected cost of the production process.We first propose the optimal switching period model,and then the mathematic formulation of the total expectation is presented.Finally,the policy of optimal switching period is investigated in detail by numerical experiments.