<strong>Objective:</strong> To date, few studies have compared the diagnostic performance and visibility of microcalcifications obtained using digital breast tomosynthesis (DBT) with those obtained from fu...<strong>Objective:</strong> To date, few studies have compared the diagnostic performance and visibility of microcalcifications obtained using digital breast tomosynthesis (DBT) with those obtained from full-field digital mammography (FFDM). The visualization and characterization of microcalcifications with DBT remain controversial. The purpose of this study was to compare the visibility of microcalcifications and determine whether DBT exhibits a diagnostic advantage for visualizing microcalcifications over FFDM.<strong> Methods: </strong>We retrospectively reviewed 120 cases including DBT and FFDM imaging (60 histologically verified as breast cancers and 60 as benign microcalcifications or normal). DBT images with a wide scan-angle of 50<span style="white-space:nowrap;"><span style="white-space:nowrap;">°</span></span> and FFDM images were obtained using a flat-panel system (MAMMOMAT Inspiration, Siemens). Images were independently reviewed by four board-certified radiologists and evaluated for the presence of microcalcifications, probability of malignancy (BI-RADS classification), and visibility. <strong>Results:</strong> In predicting the malignancy of detected microcalcifications, no significant difference was found between readers’ areas under the receiver operating characteristic curve for DBT and FFDM (p = 0.068). The visibility scores of detected microcalcifications were 3.74 <span style="white-space:nowrap;"><span style="white-space:nowrap;"><span style="white-space:nowrap;">±</span></span></span> 1.06 for DBT and 3.46 <span style="white-space:nowrap;"><span style="white-space:nowrap;"><span style="white-space:nowrap;">±</span></span></span> 0.93 for FFDM, respectively. The visibility of microcalcifications when using DBT was found to be significantly superior to that of FFDM (p < 0.05). <strong>Conclusion:</strong> Our results suggest that the image quality of DBT with a wide scan-angle is comparable or superior to that obtained with FFDM in terms of both visibility and assessment of microcalcifications.展开更多
Background: Early detection of ductal carcinoma in situ (DCIS) is essential for improving the prognosis of breast cancer. Among mammographically detected DCIS cases, approximately 10% - 20% of DCIS cases are manifeste...Background: Early detection of ductal carcinoma in situ (DCIS) is essential for improving the prognosis of breast cancer. Among mammographically detected DCIS cases, approximately 10% - 20% of DCIS cases are manifested as non-calcified. Purpose: To evaluate differences in MRI findings and histological features between mammographically evident non-calcified and calcified DCIS. Material and Methods: This study included 84 cases of pathologically proven DCIS in 82 patients who underwent preoperative breast MRI. The lesions were divided into non-calcified and calcified DCIS according to the presence of calcifications on mammography. MRI features were analyzed according to the enhancement pattern. The pathologic features were also reviewed. Results: Among the 84 DCIS cases, 30 (36%) were classified as non-calcified DCIS, and 54 (64%) as calcified DCIS on mammography. On MRI, 27% (8/30) of non-calcified DCIS and 17% (9/54) calcified DCIS presented as mass enhancement, 73% (22/30) non-calcified DCIS and 83% (45/54) calcified DCIS presented as non-mass enhancements. No significant difference in the type of lesion was observed between non-calcified and calcified DCIS (p = 0.274). Histopathologically, high nuclear grade, presence of necrosis, and presence of HER-2 status were more common in calcified DCIS than in non-calcified DCIS (p Conclusion: There were no significant differences in MRI findings between non-calcified and calcified DCIS. However, calcified DCIS had more aggressive histological features than non-calcified DCIS.展开更多
Purpose: To investigate the correlation between SUVmax of FDG-PET/CT and pathological findings including prognostic factors in early-stage T1-T2 breast cancer patients with no LN metastasis. Materials and Methods: Thi...Purpose: To investigate the correlation between SUVmax of FDG-PET/CT and pathological findings including prognostic factors in early-stage T1-T2 breast cancer patients with no LN metastasis. Materials and Methods: This retrospective study investigated 75 patients (mean age 58.9 years;age range 30 - 82 years) with invasive breast cancer who underwent FDG-PET/CT for preoperative staging. All patients underwent subsequent surgery without prior neoadjuvant chemotherapy or endocrine therapy, and those who were confirmed to have T1- or T2-stage by histopathology with no LN metastasis were included. Two patients who had no perceptible FDG accumulation on PET/CT scans were excluded. The correlations between the SUVmax of the tumor and the pathological and immunohistochemical data were evaluated. Results: The mean SUVmax for the total 73 tumors was 5.46 ± 4.05. The mean SUVmax was 3.95 ± 3.28 for the T1 stage group (n = 36) and 7.23 ± 4.10 (p p p p = 0.008), and high Ki-67 status (p < 0.001), respectively. Conclusion: In T1-T2 breast cancer with no LN metastasis, the SUVmax of FDG-PET/CT had significant positive relationships with several prognostic parameters of pathological status. Even in early-stage breast cancer patients, pretreatment FDG-PET/CT is useful for predicting malignant behavior and prognosis).展开更多
Mucinous carcinoma of the breast has histologically distinct features and constitutes 1-3% of all breast cancers. It produces variable amounts of extracellular epithelial mucin and clinically its prognosis is far bett...Mucinous carcinoma of the breast has histologically distinct features and constitutes 1-3% of all breast cancers. It produces variable amounts of extracellular epithelial mucin and clinically its prognosis is far better than for other types of invasive carcinoma. On the other hand, coarse calcification is a common mammographic feature of benign tumors. There have been few reported cases of breast cancer containing coarse calcification. We present a unique 40 year-old female case of mucinous carcinoma of the breast accompanied by coarse calcification on mammography, which was mimicking fibroadenoma and an unusual variant of breast cancer. This case illustrates the importance of bearing in mind that mucinous carcinoma may demonstrate coarse calcification.展开更多
文摘<strong>Objective:</strong> To date, few studies have compared the diagnostic performance and visibility of microcalcifications obtained using digital breast tomosynthesis (DBT) with those obtained from full-field digital mammography (FFDM). The visualization and characterization of microcalcifications with DBT remain controversial. The purpose of this study was to compare the visibility of microcalcifications and determine whether DBT exhibits a diagnostic advantage for visualizing microcalcifications over FFDM.<strong> Methods: </strong>We retrospectively reviewed 120 cases including DBT and FFDM imaging (60 histologically verified as breast cancers and 60 as benign microcalcifications or normal). DBT images with a wide scan-angle of 50<span style="white-space:nowrap;"><span style="white-space:nowrap;">°</span></span> and FFDM images were obtained using a flat-panel system (MAMMOMAT Inspiration, Siemens). Images were independently reviewed by four board-certified radiologists and evaluated for the presence of microcalcifications, probability of malignancy (BI-RADS classification), and visibility. <strong>Results:</strong> In predicting the malignancy of detected microcalcifications, no significant difference was found between readers’ areas under the receiver operating characteristic curve for DBT and FFDM (p = 0.068). The visibility scores of detected microcalcifications were 3.74 <span style="white-space:nowrap;"><span style="white-space:nowrap;"><span style="white-space:nowrap;">±</span></span></span> 1.06 for DBT and 3.46 <span style="white-space:nowrap;"><span style="white-space:nowrap;"><span style="white-space:nowrap;">±</span></span></span> 0.93 for FFDM, respectively. The visibility of microcalcifications when using DBT was found to be significantly superior to that of FFDM (p < 0.05). <strong>Conclusion:</strong> Our results suggest that the image quality of DBT with a wide scan-angle is comparable or superior to that obtained with FFDM in terms of both visibility and assessment of microcalcifications.
文摘Background: Early detection of ductal carcinoma in situ (DCIS) is essential for improving the prognosis of breast cancer. Among mammographically detected DCIS cases, approximately 10% - 20% of DCIS cases are manifested as non-calcified. Purpose: To evaluate differences in MRI findings and histological features between mammographically evident non-calcified and calcified DCIS. Material and Methods: This study included 84 cases of pathologically proven DCIS in 82 patients who underwent preoperative breast MRI. The lesions were divided into non-calcified and calcified DCIS according to the presence of calcifications on mammography. MRI features were analyzed according to the enhancement pattern. The pathologic features were also reviewed. Results: Among the 84 DCIS cases, 30 (36%) were classified as non-calcified DCIS, and 54 (64%) as calcified DCIS on mammography. On MRI, 27% (8/30) of non-calcified DCIS and 17% (9/54) calcified DCIS presented as mass enhancement, 73% (22/30) non-calcified DCIS and 83% (45/54) calcified DCIS presented as non-mass enhancements. No significant difference in the type of lesion was observed between non-calcified and calcified DCIS (p = 0.274). Histopathologically, high nuclear grade, presence of necrosis, and presence of HER-2 status were more common in calcified DCIS than in non-calcified DCIS (p Conclusion: There were no significant differences in MRI findings between non-calcified and calcified DCIS. However, calcified DCIS had more aggressive histological features than non-calcified DCIS.
文摘Purpose: To investigate the correlation between SUVmax of FDG-PET/CT and pathological findings including prognostic factors in early-stage T1-T2 breast cancer patients with no LN metastasis. Materials and Methods: This retrospective study investigated 75 patients (mean age 58.9 years;age range 30 - 82 years) with invasive breast cancer who underwent FDG-PET/CT for preoperative staging. All patients underwent subsequent surgery without prior neoadjuvant chemotherapy or endocrine therapy, and those who were confirmed to have T1- or T2-stage by histopathology with no LN metastasis were included. Two patients who had no perceptible FDG accumulation on PET/CT scans were excluded. The correlations between the SUVmax of the tumor and the pathological and immunohistochemical data were evaluated. Results: The mean SUVmax for the total 73 tumors was 5.46 ± 4.05. The mean SUVmax was 3.95 ± 3.28 for the T1 stage group (n = 36) and 7.23 ± 4.10 (p p p p = 0.008), and high Ki-67 status (p < 0.001), respectively. Conclusion: In T1-T2 breast cancer with no LN metastasis, the SUVmax of FDG-PET/CT had significant positive relationships with several prognostic parameters of pathological status. Even in early-stage breast cancer patients, pretreatment FDG-PET/CT is useful for predicting malignant behavior and prognosis).
文摘Mucinous carcinoma of the breast has histologically distinct features and constitutes 1-3% of all breast cancers. It produces variable amounts of extracellular epithelial mucin and clinically its prognosis is far better than for other types of invasive carcinoma. On the other hand, coarse calcification is a common mammographic feature of benign tumors. There have been few reported cases of breast cancer containing coarse calcification. We present a unique 40 year-old female case of mucinous carcinoma of the breast accompanied by coarse calcification on mammography, which was mimicking fibroadenoma and an unusual variant of breast cancer. This case illustrates the importance of bearing in mind that mucinous carcinoma may demonstrate coarse calcification.