脂蛋白相关磷脂酶A2水平与痴呆风险相关

Objective: High levels of the inflammatory marker lipoproteinassociated phospholipase A2 (Lp-PLA2) have been proposed to be a predictor of coronary heart disease and stroke. Because both inflammation and vascular disease are associated with dementia, the objective of the present study was to examine the association between Lp-PLA2 and the risk of dementia. Methods: Within the Rotterdam Study, a population-based prospective cohort study, we performed a case-cohort study. Of the 6,713 participants at risk for dementia, a random sample of 1,742 individuals was drawn. During follow-up (mean, 5.7 years), 302 incident dementia cases were identified. Cox proportional hazard models were used to estimate the association of Lp-PLA2 and dementia. Results: We found that subjects with higher levels of Lp-PLA2 had an increased risk of dementia. Compared with the first quartile of Lp-PLA2, ageand sex-adjusted hazard ratios (HRs; 95% confidence interval [CI]) for dementia for the second, third, and fourth quartiles were 1.19 (0.78- 1.81), 1.15 (0.74- 1.79), and 1.56 (1.03- 2.37), respectively (p value for trend 0.04). Additional adjustment for cardiovascular and inflammatory factors did not change the estimates. Interpretation: This is the first study to our knowledge that shows that Lp-PLA2 is associated with the risk of dementia independent of cardiovascular and inflammatory factors and provides evidence for a potential role of Lp-PLA2 in identifying subjects at risk for dementia.

前蛋白转化酶枯草溶菌素1常见基因型变异对血压和体质量指数的影响

前蛋白转化酶枯草溶菌素1（proproteinconver—tasesubt．1isin／kexin—type1，PCSKl）可激活前体阿黑皮素原（pro—opiomelanocortin，POMC）、胰岛素原和肾素。该研究旨在确定PCSKl基因常见变异是否会影响血压和高血压发生，以及肥胖和2型糖尿病（type2diabetesmellitus，T2DM）的发生风险。

颈动脉内膜中层厚度测量未改善高血压患者心血管风险预测

颈动脉内膜中层厚度（carotid intima-media thickness,CIMT）是心血管风险的标志。目前仍不清楚颈总动脉CIMT测量能否改善高血压患者10年内首发心肌梗死或脑卒中的风险预测。研究人员获取正在进行的大规模荟萃分析：USE-IMT研究中的高血压参与者（收缩压≥140和舒张压≥90 mm Hg,1mm Hg=0.133kPa）数据进行分析。