Objective:To evaluate the antifungal and inhibitory activity of six different species of marine sponges and one species of sea anemone that were collected from the Persian Gulf on the growth of Candida albicans(C.albi...Objective:To evaluate the antifungal and inhibitory activity of six different species of marine sponges and one species of sea anemone that were collected from the Persian Gulf on the growth of Candida albicans(C.albicans).Methods:Sea anemone and six different sponges were gathered from the Persian Gulf and extracted by methanol macerated with dichloromethane solvents.The activity of each extracts against C.albicans was determined by paper disc diffusion and agar well diffusion methods.Also,minimum inhibitory concentration and minimal bactericidal concentration of each extract were determined.Results:The finding of current research confirmed that all sponge extracts had sufficient inhibitory effect against C.albicans but the extracts of sponge type 2 and 5 had the best inhibitory effect on C.albicans and their zones of inhibition were 45 mm and 38 mm,respectively.The tentacle of sea anemone had the best inhibitory effect against C.albicans compared to other part of the body and its zone of inhibition was 41 mm.Besides,the sponge type 5 extracts had the best minimum inhibitory concentration and minimal bactericidal concentration values with 6.25 and 12.5 mg/mL,respectively.Conclusions:It could be concluded that the crude extracts of six different sponges and sea anemone have high potential to produce broad spectral antifungal activity with minimal concentration against different pathogenic fungi.展开更多
基金Supported by Shahid Bahonar University of Kerman with grant number 1645.
文摘Objective:To evaluate the antifungal and inhibitory activity of six different species of marine sponges and one species of sea anemone that were collected from the Persian Gulf on the growth of Candida albicans(C.albicans).Methods:Sea anemone and six different sponges were gathered from the Persian Gulf and extracted by methanol macerated with dichloromethane solvents.The activity of each extracts against C.albicans was determined by paper disc diffusion and agar well diffusion methods.Also,minimum inhibitory concentration and minimal bactericidal concentration of each extract were determined.Results:The finding of current research confirmed that all sponge extracts had sufficient inhibitory effect against C.albicans but the extracts of sponge type 2 and 5 had the best inhibitory effect on C.albicans and their zones of inhibition were 45 mm and 38 mm,respectively.The tentacle of sea anemone had the best inhibitory effect against C.albicans compared to other part of the body and its zone of inhibition was 41 mm.Besides,the sponge type 5 extracts had the best minimum inhibitory concentration and minimal bactericidal concentration values with 6.25 and 12.5 mg/mL,respectively.Conclusions:It could be concluded that the crude extracts of six different sponges and sea anemone have high potential to produce broad spectral antifungal activity with minimal concentration against different pathogenic fungi.
