深化政治交接 广泛凝聚团结奋斗力量

各民主党派深化政治交接,是贯彻落实中共二十大精神、推进多党合作事业持续健康发展和确保民主党派薪火永续的必然要求。新时代新征程的新使命新任务,对民主党派服务党和国家工作大局提出了新的更高要求,也为民主党派发挥凝心聚力作用提供了更加广阔的舞台。作为中国特色社会主义参政党,九三学社要牢牢把握新时代爱国统一战线和多党合作的历史新方位,准确把握新时代新征程政治交接的丰富内涵,把政治交接贯穿于凝聚共识各环节、贯穿于履职实践各方面、贯穿于自身建设各领域,努力建设高水平高素质的新时代中国特色社会主义参政党,为全面建设社会主义现代化国家而团结奋斗。

Mechanoluminescent-Triboelectric Bimodal Sensors for Self-Powered Sensing and Intelligent Control

Self-powered flexible devices with skin-like multiple sensing ability have attracted great attentions due to their broad applications in the Internet of Things(IoT).Various methods have been proposed to enhance mechano-optic or electric performance of the flexible devices;however,it remains challenging to realize the display and accurate recognition of motion trajectories for intelligent control.Here,we present a fully self-powered mechanoluminescent-triboelectric bimodal sensor based on micronanostructured mechanoluminescent elastomer,which can patterned-display the force trajectories.The deformable liquid metals used as stretchable electrode make the stress transfer stable through overall device to achieve outstanding mechanoluminescence(with a gray value of 107 under a stimulus force as low as 0.3 N and more than 2000 cycles reproducibility).Moreover,a microstructured surface is constructed which endows the resulted composite with significantly improved triboelectric performances(voltage increases from 8 to 24 V).Based on the excellent bimodal sensing performances and durability of the obtained composite,a highly reliable intelligent control system by machine learning has been developed for controlling trolley,providing an approach for advanced visual interaction devices and smart wearable electronics in the future IoT era.

基于SPR技术的抗CD80生物技术药物结合活性方法的建立

目的基于表面等离子共振(SPR)技术建立抗CD80生物技术药物结合活性方法,并进行方法学验证和样品测定。方法通过优化试验条件建立合适的结合活性方法,并选择合适的数据分析模型后对建立的方法进行方法学验证。结果通过对各种条件进行筛选及耐用性考察,确定了方法的试验参数:配体固定条件为pH 5.0的醋酸盐缓冲液,固定量为400~5000 RU,结合和解离速率为10~50μL·min^(-1),芯片的再生条件为pH 4.0的枸橼酸缓冲液(10 mmol·L^(-1)枸橼酸钠,100 mmol·L^(-1)NaCl),响应参数为稳态相对响应值(在进样结束后10 s范围内窗口的平均响应值),数据模型为四参数模型。根据以上参数建立了基于SPR技术抗CD80生物技术药物结合活性方法。验证结果如下:线性回归方程的决定系数为0.9994;每个效价水平相对效价测定值的相对偏倚平均值为-0.66%~0.64%,线性回归方程的斜率为0.9867;每个效价水平6次独立测试结果的几何变异系数为0.7%~1.5%,范围为64%~156%。各项验证指标均满足相关验证要求,专属性结果也较好。将建立的结合活性方法应用于抗CD80生物技术药物,测得结合活性相对效价为100%。结论本研究通过优化试验条件建立了基于SPR技术的抗CD80生物技术药物结合活性方法,该方法专属性强、重复性好、准确度高。

Clinical and Experimental Study of Low Molecular Weight Heparin in Patients with Chronic Anemia

Objective: To preliminary study the significance of low molecular weight heparin (LMWH) in the treatment patients of with anemia of chronic diseases (ACD), and the changes in the serum levels of BMP6, hepcidin and IL-6. To preliminary study the significance of low molecular weight heparin (LMWH) in the treatment the patients with anemia of chronic diseases (ACD), and the changes in the serum levels of BMP6, hepcidin and IL-6. Methods: Used LMWH (4000 u/day, 7 - 15 days) to therapy 61 patients with ACD, and ELISA method was used to determine Hepcidin and BMP6 before and after treatment, and the determination of IL-6 by Electro-chemi-luminescence, and to analyze its clinical significance. Results: 1) In all 61 cases, the levels of Hepcidin in post-therapy were 0.82 ± 0.24 mg/L, which were lower than 1.05 ± 3.83 mg/L in pre-therapy (t = 2.5726, P < 0.05). The levels of IL-6 in post-therapy were 24.88 ± 12.58 mg/L, which were lower than 38.22 ± 31.23 mg/L in pre-therapy (t = 2.9650, P < 0.05), but there were no statistically significant both Hb and BMP6 between in pre-therapy and post-therapy (all P > 0.05). However, The levels of Hb in post-therapy were higher than in pre-therapy (t = 1.9832, P < 0.05). 2) The Hb level in the tumor anemia group after treatment was 91.18 ± 15.91 g/L, which was higher than that before treatment (85.45 ± 18.33 g/L), the difference was statistically significant (t = 1.9711, P < 0.05). 3) The levels of hepcidin and IL-6 in the tumor anemia group after treatment were 0.73 ± 0.45 mg/L and 30.33 ± 28.39 mg/ml, which were lower than those before treatment (1.09 ± 0.41 mg/L and 50.76 ± 42.10 mg/ml), respectively, the difference was statistically significant (t = 3.3941, P < 0.01 and t = 2.3597, P < 0.05). 4) There was no significant difference in all indexes in tumor anemia free group (all P > 0.05). 5) Although Hb level increased slightly in the non-tumor anemia group, there was no statistical significance (P > 0.05), and there was no statistical difference in other indexes (all P > 0.05). 6) After treatment, the level of Hb was negatively correlated with Hepcidin and IL-6 (respectively r = -0.2809, t = 2.2490, P < 0.05 and r = -0.2781, t = 2.2266, P < 0.05). Hepcidin was positively related to IL-6 (r = -0.2941, t = 2.3622, P < 0.05). There was no correlation between BMP6 and Hb, Hepcidin and IL-6 levels. Conclusion: LMWH could up-regulate the levels of Hb, and better for the degree of anemia in patients with ACD. The possible mechanism is to reduce the level of Hepcidin and IL-6.

Treatment of dyslipidemia in the elderly

Dyslipidemia 是为动脉粥样硬化的一个生长得很好的风险因素。在老病人对待 dyslipidemia 面对可能的多重 comorbidities 要求普通 dyslipidemias 的特定的知识和各种各样的 pharmacologic 代理人的相对安全。第一在 dyslipidemia 的治疗走的生活方式修正遗体；然而，支撑并且完成可接受的依从在能是困难的老并且它最好与药治疗在联合被使用。Statins 广泛地作为首要的治疗被接受。几最近的研究证明了 statins 在安全、有效老。然而，注意在超过 85 岁的病人关于病态和死亡上的 dyslipidemia 治疗的效果有很有限的数据是重要的。在摘要，临床医生必须认识到在老姿势的 dyslipidemia 的存在冠的事件和击的实质的风险。可得到的证据证明了在大多数，在的老病人为心血管的病态和死亡增加了风险，有适当治疗的 dyslipidemia 的治疗减少风险，并且当与为安全的靠近的监视小心地使用了时，治疗通常好容忍。与增加预期寿命，医生认出察觉的重要性和 dyslipidemia 的治疗在是批评的老。

A Preprocessing Method for Gait Recognition

The results of image preprocessing may directly affect gait feature extraction in the area of gait recognition. Due to the influence of light, shelter and other external factors of gait image, some problems such as loss of information,image shadows, and improper threshold of image preprocessing may occur. In order to solve these problems, an image preprocessing method of gait recognition is proposed. Firstly, background image is extracted by background modeling, secondly, the target profile is extracted by the direct difference method; thirdly, the shadow elimination based on the HSV color model is carried out on the target profile map; Finally, the complete target profile is obtained by threshold segmentation. Experimental results on CASIA_A database demonstrate that this proposed method is quite effective on both target profile extraction and proportion comparison with the real area.

High performance Aurivillius type Na_(0.5)Bi_(4.5)Ti_(4)O_(15) piezoelectric ceramics with neodymium and cerium modification

Bismuth layer-structured ferroelectric ceramics of Na0.5Bi4.5-x(Nd_(0.5)Ce_(0.5)))xTi4O15(NBT-x,0.0≤x≤0.4)were synthesized by a traditional solid-state reaction.The effect of(Nd,Ce)substitution for A-site on the microstructure and electrical properties of Na_(0.5)Bi_(4.5)Ti_(4)O_(15)(NBT)-based piezoelectric ceramics was investigated.X-ray diffraction(XRD)analysis revealed that the(Nd,Ce)-modified NBT ceramics have a pure four-layer Aurivillius type structure.The piezoelectric properties of NBT ceramics were significantly improved by the modification of neodymium and cerium.The Curie temperature TC gradually decreased from 638℃to 618℃with increasing the(Nd,Ce)modification.The piezoelectric constant d33,mechanical quality factor Qm,dielectric loss tanδand Curie temperature TC of the Na0.5Bi4.3(Nd_(0.5)Ce_(0.5)))0.2Ti4O15 ceramic were found to be 28 pC/N,3239,0.0032 and 630℃,respectively.Thermal annealing studies indicated that the(Nd,Ce)-modified NBT ceramics possess stable piezoelectric properties,demonstrating that the Na0.5Bi4.3(Nd_(0.5)Ce_(0.5)))0.2Ti4O15 ceramic is a promising candidate for high temperature applications.

LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice

Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.

Revealing Functional Significance of Interleukin-2 Glycopro-teoforms Enabled by Expressed Serine Ligation

Naturally occurring interleukin-2(IL-2)is a pleiotropic glycoprotein that regulates immune responses by controlling the differentia-tion and homeostasis of T cells.Non-glycosylated IL-2 has been used in clinical settings for three decades.However,the function of the O-glycan of native IL-2 remains elusive.Herein,to stress this issue,we report a highly efficient semi-synthesis of homogeneous glycosylated IL-2 with various glycoproteoforms on a multi-milligram scale.The glycopeptide fragment was prepared by chemical synthesis and then merged with recombinant fragment via a serine ligation to generate the desired glycoprotein in a single opera-tion.Biological evaluation of the homogenous glycoprotein library reveals that the activity of IL-2 in activating individual T cell subset is glycan dependent,thus highlighting the possibility of further improving current clinical medicine.

Face recognition based on subset selection via metric learning on manifold

With the development of face recognition using sparse representation based classification(SRC), many relevant methods have been proposed and investigated. However, when the dictionary is large and the representation is sparse, only a small proportion of the elements contributes to the l1-minimization. Under this observation,several approaches have been developed to carry out an efficient element selection procedure before SRC. In this paper, we employ a metric learning approach which helps find the active elements correctly by taking into account the interclass/intraclass relationship and manifold structure of face images. After the metric has been learned, a neighborhood graph is constructed in the projected space. A fast marching algorithm is used to rapidly select the subset from the graph, and SRC is implemented for classification. Experimental results show that our method achieves promising performance and significant efficiency enhancement.

Establishment of a pseudovirus neutralization assay based on SARS-CoV-2 S protein incorporated into lentiviral particles

The coronavirus disease 2019(COVID‐19)is still causing a wide range of infections and deaths due to the high variability of the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2).Therefore,it is necessary to establish a reliable and convenient pseudovirus‐based neutralization assay to develop drug targeted variants of SARS‐CoV‐2.Based on the HIV‐1 backbone,we generated a high titer luciferase(Luc)‐expressing pseudovirus packaging system.Three dominant S mutant substitution pseudovirus were also established and identified compared to wide type in hACE2‐overexpressingHEK‐293T cells(293T‐ACE2 cells).Compared to serine protease inhibitor camostat mesylate,the cysteine protease inhibitor E‐64d could significantly block all SARS‐CoV‐2 mutant S pseudovirus infection in 293T‐ACE2 cells.Furthermore,the neutralization ability of two antibodies targeted receptor‐binding domain(RBD)of SARS‐CoV‐2 spike protein(S)was evaluated,which showeddifferent inhibition dose–effect curves among four types of S pseudovirus.Overall,we developed a pseudovirus‐based neutralization assay for SARS‐CoV‐2,which would be readily adapted to SARS‐CoV‐2 variants for evaluating antibodies.