针对低轨卫星物联网场景下基于窄带物联网(narrow band Internet of Things,NB-IoT)体制的物联终端大尺度地理范围内多场景应用业务时延和终端功耗需求动态变化问题,提出一种利用马尔可夫链模型评估NB-IoT终端在扩展不连续接收(extended...针对低轨卫星物联网场景下基于窄带物联网(narrow band Internet of Things,NB-IoT)体制的物联终端大尺度地理范围内多场景应用业务时延和终端功耗需求动态变化问题,提出一种利用马尔可夫链模型评估NB-IoT终端在扩展不连续接收(extended discontinuous reception,eDRX)和节能模式(power saving mode,PSM)下的时延功耗的方法,建立了以下行业务延迟和终端功耗为优化目标的多目标优化问题。在信关站利用终端历史业务数据信息离线训练基于支持向量机(support vector machine,SVM)的时延功耗的回归预测模型,以回归预测模型作为非支配排序遗传算法(non-dominated sorting genetic algorithms-II,NSGA-II)的目标函数,得到多目标优化问题的Pareto前沿解集,进一步从Pareto前沿解集中选择满足当前应用时延功耗需求的工作状态定时器参数值,在线配置终端。仿真结果表明,相比于传统的地面物联网终端固定式定时器参数配置方法,所提出的业务驱动的定时器参数配置方法在终端动态多场景应用下能够更好地满足业务时延和终端功耗需求。展开更多
目的:通过体外模拟消化酵解和细胞炎症模型探究江蓠、红毛藻、麒麟菜和坛紫菜等4种经济红藻的消化酵解特性及其抗炎潜力,为红藻的高附加值开发提供依据。方法:通过体外模拟口胃肠消化和结肠发酵,测定4种红藻中总糖、还原糖、蛋白质和总...目的:通过体外模拟消化酵解和细胞炎症模型探究江蓠、红毛藻、麒麟菜和坛紫菜等4种经济红藻的消化酵解特性及其抗炎潜力,为红藻的高附加值开发提供依据。方法:通过体外模拟口胃肠消化和结肠发酵,测定4种红藻中总糖、还原糖、蛋白质和总酚的去向。利用16S r RNA基因Illumina MiSeq测序分析红藻对肠道菌群的影响,同时通过高效液相色谱法分析发酵产物中短链脂肪酸的含量,并采用脂多糖诱导的RAW264.7细胞炎症模型评价4种红藻发酵产物的抗炎活性。结果:在口胃肠消化过程中,坛紫菜对碳水化合物、蛋白质及酚类物质具有较好的生物利用度。难以消化的部分到达结肠后充当肠道微生物群的能量来源,其中坛紫菜在发酵过程中产生更多的短链脂肪酸。同时,4种红藻均表现出调节肠道菌群的能力,包括提高拟杆菌门的丰度,降低厚壁菌门/拟杆菌门的比值。此外,红藻发酵液对脂多糖诱导的RAW264.7细胞炎症损伤具有显著抑制作用,红毛藻发酵液具有更好的抑制效果。结论:4种红藻经模拟消化后有较好的生物可及性,能够调节肠道微生物群,同时表现出较好的抗炎潜力,为基于红藻的高值活性产品的开发提供科学依据。展开更多
Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in vivo.Methods Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body w...Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in vivo.Methods Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after administration.Histopathology was performed to corroborate these findings.Results In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(P<0.05).In the 3μm group,the FI only increased in the lung at 2 h(P<0.05).In the 10μm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(P<0.05).The presence of nano-/microplastics in tissues was further verified by histopathology.The peak time of nanoplastic absorption in blood was confirmed.Conclusion Nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs.展开更多
文摘针对低轨卫星物联网场景下基于窄带物联网(narrow band Internet of Things,NB-IoT)体制的物联终端大尺度地理范围内多场景应用业务时延和终端功耗需求动态变化问题,提出一种利用马尔可夫链模型评估NB-IoT终端在扩展不连续接收(extended discontinuous reception,eDRX)和节能模式(power saving mode,PSM)下的时延功耗的方法,建立了以下行业务延迟和终端功耗为优化目标的多目标优化问题。在信关站利用终端历史业务数据信息离线训练基于支持向量机(support vector machine,SVM)的时延功耗的回归预测模型,以回归预测模型作为非支配排序遗传算法(non-dominated sorting genetic algorithms-II,NSGA-II)的目标函数,得到多目标优化问题的Pareto前沿解集,进一步从Pareto前沿解集中选择满足当前应用时延功耗需求的工作状态定时器参数值,在线配置终端。仿真结果表明,相比于传统的地面物联网终端固定式定时器参数配置方法,所提出的业务驱动的定时器参数配置方法在终端动态多场景应用下能够更好地满足业务时延和终端功耗需求。
文摘目的:通过体外模拟消化酵解和细胞炎症模型探究江蓠、红毛藻、麒麟菜和坛紫菜等4种经济红藻的消化酵解特性及其抗炎潜力,为红藻的高附加值开发提供依据。方法:通过体外模拟口胃肠消化和结肠发酵,测定4种红藻中总糖、还原糖、蛋白质和总酚的去向。利用16S r RNA基因Illumina MiSeq测序分析红藻对肠道菌群的影响,同时通过高效液相色谱法分析发酵产物中短链脂肪酸的含量,并采用脂多糖诱导的RAW264.7细胞炎症模型评价4种红藻发酵产物的抗炎活性。结果:在口胃肠消化过程中,坛紫菜对碳水化合物、蛋白质及酚类物质具有较好的生物利用度。难以消化的部分到达结肠后充当肠道微生物群的能量来源,其中坛紫菜在发酵过程中产生更多的短链脂肪酸。同时,4种红藻均表现出调节肠道菌群的能力,包括提高拟杆菌门的丰度,降低厚壁菌门/拟杆菌门的比值。此外,红藻发酵液对脂多糖诱导的RAW264.7细胞炎症损伤具有显著抑制作用,红毛藻发酵液具有更好的抑制效果。结论:4种红藻经模拟消化后有较好的生物可及性,能够调节肠道微生物群,同时表现出较好的抗炎潜力,为基于红藻的高值活性产品的开发提供科学依据。
基金supported by National Natural Science Foundation of China[grant number U21A20399]Liaoning Revitalization Talents Program[grant number XLYC1802059]+2 种基金the Key R&D Program of Liaoning Province[grant number2019JH2/10300044]the Key Laboratory Program of Liaoning Province[grant number 2018225113]the Key Laboratory Program of Shenyang City[grant number 21-103-0-16]。
文摘Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in vivo.Methods Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after administration.Histopathology was performed to corroborate these findings.Results In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(P<0.05).In the 3μm group,the FI only increased in the lung at 2 h(P<0.05).In the 10μm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(P<0.05).The presence of nano-/microplastics in tissues was further verified by histopathology.The peak time of nanoplastic absorption in blood was confirmed.Conclusion Nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs.
