The oxidation behavior of a novel Ni-based single-crystal 4774DD1 superalloy for industrial gas turbine applications was investigated by the isothermal oxidation at 980℃ and discontinuous oxidation weight gain method...The oxidation behavior of a novel Ni-based single-crystal 4774DD1 superalloy for industrial gas turbine applications was investigated by the isothermal oxidation at 980℃ and discontinuous oxidation weight gain methods.The phase constitution and morphology of surface oxides and the characteristics of the crosssection oxide film were analyzed by XRD,SEM and EDS.Results show that the oxidation kinetics of the 4774DD1 superalloy follows the cubic law,indicating its weak oxidation resistance at this temperature.As the oxidation time increases,the composition of the oxide film evolves as following:One layer consisting of a bottom Al_(2)O_(3)sublayer and an upper(Al_(2)O_(3)+NiO)mixture sublayer after oxidized for 25 h.Then,two layers composed of an outermost small NiO discontinuous grain layer and an internal layer for 75 h.This internal layer is consisted of the bottom Al_(2)O_(3)sublayer,an intermediate narrow CrTaO_(4)sublayer,and an upper(Al_(2)O_(3)+NiO)mixture sublayer.Also two layers comprising an outermost relative continuous NiO layer with large grain size and an internal layer as the oxidation time increases to 125 h.This internal layer is composed of the upper(Al_(2)O_(3)+NiO)mixture sublayer,an intermediate continuous(CrTaO_(4)+NiWO_(4))mixture sublayer,and a bottom Al_(2)O_(3)sublayer.Finally,three layers consisting of an outermost(NiAl2O_(4)+NiCr2O_(4))mixture layer,an intermediate(CrTaO_(4)+NiWO_(4))mixture layer,and a bottom Al_(2)O_(3)layer for 200 h.展开更多
BACKGROUND Cervical haemorrhage due to spontaneous rupture of a parathyroid adenoma is a rare complication that may cause life-threatening acute airway compromise.CASE SUMMARY A 64-year-old woman was admitted to the h...BACKGROUND Cervical haemorrhage due to spontaneous rupture of a parathyroid adenoma is a rare complication that may cause life-threatening acute airway compromise.CASE SUMMARY A 64-year-old woman was admitted to the hospital 1 day after the onset of right neck enlargement, local tenderness, head-turning difficulty, pharyngeal pain, and mild dyspnoea. Repeat routine blood testing showed a rapid decrease in the haemoglobin concentration, indicating active bleeding. Enhanced computed tomography images showed neck haemorrhage and a ruptured right parathyroid adenoma. The plan was to perform emergency neck exploration, haemorrhage removal, and right inferior parathyroidectomy under general anaesthesia. The patient was administered 50 mg of intravenous propofol, and the glottis was successfully visualised on video laryngoscopy. However, after the administration of a muscle relaxant, the glottis was no longer visible and the patient had a difficult airway that prevented mask ventilation and endotracheal intubation. Fortunately, an experienced anaesthesiologist successfully intubated the patient under video laryngoscopy after an emergency laryngeal mask placement. Postoperative pathology showed a parathyroid adenoma with marked bleeding and cystic changes. The patient recovered well without complications.CONCLUSION Airway management is very important in patients with cervical haemorrhage. After the administration of muscle relaxants, the loss of oropharyngeal support can cause acute airway obstruction.Therefore, muscle relaxants should be administered with caution. Anaesthesiologists should pay careful attention to airway management and have alternative airway devices and tracheotomy equipment available.展开更多
In stroke rehabilitation,rehabilitation equipments can help with the training.But traditional equipments are not convenient to carry,which limits patients to use related rehabilitation techniques.To solve this kind of...In stroke rehabilitation,rehabilitation equipments can help with the training.But traditional equipments are not convenient to carry,which limits patients to use related rehabilitation techniques.To solve this kind of problem,a new embedded rehabilitation system based on brain computer interface(BCI)is proposed in this paper.The system is based on motor imagery(MI)therapy,in which electroencephalogram(EEG)is evoked by grasping motor imageries of left and right hands,then collected by a wearable device.The EEG is transmitted to a Raspberry Pie processing unit through Bluetooth and decoded as the instructions to control the equipment extension.Users experience the limb movement through the visual feedback so as to achieve active rehabilitation.A pilot study shows that the user can control the movement of the rehabilitation equipment through his mind,and the equipment is convenient to carry.The study provides a new way to stroke rehabilitation.展开更多
BACKGROUND: The study aims to investigate the occurrence of post-traumatic stress disorder(PTSD) after earthquakes among the elderly. METHODS: Data from cross-sectional studies focusing on the prevalence of PTSD after...BACKGROUND: The study aims to investigate the occurrence of post-traumatic stress disorder(PTSD) after earthquakes among the elderly. METHODS: Data from cross-sectional studies focusing on the prevalence of PTSD after earthquakes among the elderly were collected from Pub Med, EMBASE, Cochrane Library, and China National Knowledge Infrastructure in December 2019. The search terms included post-traumatic stress disorder, earthquake, and elderly. This study used Review Manager 5.0 to evaluate the impact of the results. In addition, forest plots, sensitivity analysis, and bias analysis were carried out on the included articles. The combined estimate of the risk ratio and the standard deviation of the 95% confidence interval(95% CI) were measurements of the size of the effect.RESULTS: There were 4,834 patients included from 10 eligible studies. The sample sizes of PTSD group and non-PTSD group were 1,277 and 3,557, respectively. The meta-analysis showed that the overall occurrence of PTSD after earthquakes among the elderly was 0.25;the occurrence in females was higher than that in males, and the occurrence in the same province indicated little difference(Wenchuan city 0.25 and Ya'an city 0.24).CONCLUSIONS: After earthquakes, the occurrence of PTSD is higher among the elderly than among other age groups, and higher among the females than among the males, while there is little difference among different areas within the same province. This indicated that prioritized specific psychological interventions should be provided to the aged and the females.展开更多
Accumulated temperature,which is now widely used in agronomy,is an important ecological factor to the growth of plants,but few relative studies have been found on the vegetation area of floodplain grasslands in Poyang...Accumulated temperature,which is now widely used in agronomy,is an important ecological factor to the growth of plants,but few relative studies have been found on the vegetation area of floodplain grasslands in Poyang Lake.This research used the classification and regression tree(CART)to classify normalized vegetation area index derived from MODIS LAI(Moderate Resolution Imaging Spectroradiometer Leaf Area Index)images from 2008 to 2014,according to different climate indexes,such as mean daily air temperature(n),accumulated temperature(jw),daily maximum temperature(g),daily minimum temperature(d),accumulative precipitation(j),water level(s)and average water level for 20 days preceding(a).The results showed that:(1)The accumulated temperature and the 20-day average WL(water level)were found to have the greatest impact on variation in wetland vegetation area,and they both dominated the classification process twice;(2)Two classification thresholds of accumulated temperature were 790°C and 1784°C,approximately corresponding to the beginning of April and midMay;(3)790°C could also be used as a threshold to select remote sensing images to analysis the annual variability of vegetation,i.e.while accumulated temperature is lower than 790°C,remote sensing images of similar accumulated temperature rather than similar date should be selected from different years for comparison.We also found that,effects of different hydrological factors on area of floodplain grasslands showed stage characteristics:(1)From January to March,water level changes slowly with less rainfall,as a result,the 20-day average WL which can interpret the hydrologic characteristics smoothly showed significant importance in this stage;(2)While entering April,intense rainfall make accumulative precipitation to be the dominating factor of classification;(3)From late April to mid-May,in condition of accumulative precipitation higher than 405 mm,daily water level is of most importance,because to the flood recession process as well as rapid water level fluctuations.展开更多
The recent discovery of room temperature superconductivity(283 K)in carbonaceous sulfur hydride(C-S-H)has attracted much interest in ternary hydrogen rich materials.In this report,ternary hydride P-S-H was synthesized...The recent discovery of room temperature superconductivity(283 K)in carbonaceous sulfur hydride(C-S-H)has attracted much interest in ternary hydrogen rich materials.In this report,ternary hydride P-S-H was synthesized through a photothermal-chemical reaction from elemental sulfur(S),phosphorus(P)and molecular hydrogen(H_(2))at high pressures and room temperature.Raman spectroscopy under pressure shows that H_(2)S and PH_(3) compounds are synthesized after laser heating at 0.9 GPa,and a ternary van der Waals compound P-S-H is synthesized with further compression to 4.6 GPa.The P-S-H compound is probably a mixed alloy of PH_(3) and(H_(2)S)_(2)H_(2) with a guest-host structure similar to the C-S-H system.The ternary hydride can persist up to 35.6 GPa at least and shows two phase transitions at approximately 23.6 GPa and 32.8 GPa,respectively.展开更多
The layered van der Waals antiferromagnetic Fe PS_(3) has received considerable attention because long range magnetic ordering can remain with single atoms layer,which offers potential applications in future ultrathin...The layered van der Waals antiferromagnetic Fe PS_(3) has received considerable attention because long range magnetic ordering can remain with single atoms layer,which offers potential applications in future ultrathin devices.Here,we perform Raman spectroscopy to systematically explore the variations of lattice vibration and crystal structure under pressure up to 18.9 GPa.We observe two structural phase transitions at approximately 4 GPa and 13 GPa,respectively.Moreover,by monitoring spin-related Raman modes,we demonstrate a pressure-induced magnetic structure transition above 2 GPa.These modes disappear accompanying the second structural phase transition and insulator-to-metal transition(IMT),indicating the suppression of long-range magnetic ordering,in agreement with earlier neutron powder diffraction experiments.展开更多
Cognitive state detection using electroencephalogram(EEG)signals for various tasks has attracted significant research attention.However,it is difficult to further improve the performance of crosssubject cognitive stat...Cognitive state detection using electroencephalogram(EEG)signals for various tasks has attracted significant research attention.However,it is difficult to further improve the performance of crosssubject cognitive state detection.Further,most of the existing deep learning models will degrade significantly when limited training samples are given,and the feature hierarchical relationships are ignored.To address the above challenges,we propose an efficient interpretation model based on multiple capsule networks for cross-subject EEG cognitive state detection,termed as Efficient EEG-based Multi-Capsule Framework(E3GCAPS).Specifically,we use a selfexpression module to capture the potential connections between samples,which is beneficial to alleviate the sensitivity of outliers that are caused by the individual differences of cross-subject EEG.In addition,considering the strong correlation between cognitive states and brain function connection mode,the dynamic subcapsule-based spatial attention mechanism is introduced to explore the spatial relationship of multi-channel 1D EEG data,in which multichannel 1D data greatly improving the training efficiency while preserving the model performance.The effectiveness of the E3GCAPS is validated on the Fatigue-Awake EEG Dataset(FAAD)and the SJTU Emotion EEG Dataset(SEED).Experimental results show E3GCAPS can achieve remarkable results on the EEG-based cross-subject cognitive state detection under different tasks.展开更多
BACKGROUND Recurrent hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus is a great challenge for oncologists and has a poor prognosis.To date,the safety and efficacy of programmed cell death ligand 1(...BACKGROUND Recurrent hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus is a great challenge for oncologists and has a poor prognosis.To date,the safety and efficacy of programmed cell death ligand 1(PD-L1)inhibitors are still unknown.CASE SUMMARY A 59-year-old male was identified as having a tumor thrombus in the inferior vena cava 3 years after surgery.The patient underwent a second surgery and adjuvant chemotherapy.However,the level of alpha-fetoprotein was elevated after 2 mo,and lung metastases and mediastinal lymph node metastases were identified.The expression of PD-L1 in HCC and inferior vena cava tumor thrombus tissues was analyzed by immunohistochemistry.Then,the patient received atezolizumab immunotherapy.The level of alpha-fetoprotein dropped to normal,the mediastinal lymph node metastases decreased in size and the lung metastases disappeared after 3 mo of immunotherapy.The patient had no signs of recurrence at 21 mo of follow-up.A 60-year-old male underwent left hepatic tumor resection,inferior vena cava incision and thrombus removal,followed by regular chemotherapy.The patient developed lung and splenic metastases after surgery.Pembrolizumab was used for six courses,and the splenic metastasis shrank,after which splenectomy was performed.The patient continued to receive pembrolizumab for thirteen courses,and the lung metastases showed no progression.A 34-year-old male was diagnosed with liver cancer with inferior vena cava tumor thrombus.The patient underwent right hepatectomy and received tislelizumab for three courses.He is still receiving immunotherapy and in good condition.CONCLUSION Anti-PD-L1 therapy in HCC patients with inferior vena cava tumor thrombus and metastasis is associated with relatively good patient outcomes.展开更多
Background:The coronavirus(COVID-19)outbreak in 2019 triggered psychological and emotional responses.This research investigates the psychological status and emotional problems of those who sought psychological assista...Background:The coronavirus(COVID-19)outbreak in 2019 triggered psychological and emotional responses.This research investigates the psychological status and emotional problems of those who sought psychological assistance during the epidemic period by calling a mental health hotline.Methods:This study aims to combine qualitative and quantitative research.Descriptive analysis was used for undertaking qualitative research.We ana-lyzed the data from group 1(n=706),in which the people used the mental health hotline from 25 January 2020 to 23 June 2020.A self-designed questionnaire was developed in accordance with the classification and sum-marized items from group 1’s psychological problems and emotional status.To implement the quantitative research,we conducted a cross-sectional descriptive survey and used the self-compiled scale and HADS to inves-tigate group 2(n=553)from May 2020 to June 2020.Results:Descriptive statistics and comparative analysis revealed that:①Visitors mainly reported behavior,emotional,family relationship problems and sleep disorders.②Anxiety,comorbidities,sleep disorders and coping problems were the most frequently reported problems.③There were significant differences in the number of visitors experiencing various problems or exhibiting harmful behaviors(sorrow,worry,fear,depression,sleep disorders,self-harm or suicide,and coping problems,anxiety,hypochondria,and comorbidity)in the four stages of the epidemic.④More than a quarter of participants still suffered from anxiety or depression in the later stages of the epidemic.Conclusion:Different problems manifested at different stages of the epidemic,and psychological interventions and assistance should be tailored to reflect this.展开更多
目的分析不同分型乳头状肾细胞癌(pRCC)的临床特征及治疗效果,探讨pRCC预后相关危险因素。方法回顾性收集了中山大学孙逸仙纪念医院2011年1月至2021年10月经微创手术治疗且病理确诊的70例pRCC患者的临床及病理资料。所有患者术前已排除...目的分析不同分型乳头状肾细胞癌(pRCC)的临床特征及治疗效果,探讨pRCC预后相关危险因素。方法回顾性收集了中山大学孙逸仙纪念医院2011年1月至2021年10月经微创手术治疗且病理确诊的70例pRCC患者的临床及病理资料。所有患者术前已排除远处转移,并对患者生存及复发转移情况进行跟踪随访,随访至2021年12月底,以出现疾病进展或任何原因的死亡为终点。采用Kaplan-Meier法绘制生存曲线,COX回归用于多因素分析无进展生存(PFS)的危险因素。结果70例患者均诊断为pRCC,包括21例Ⅰ型及49例Ⅱ型,其中男55例,中位年龄57岁。中位肿瘤直径为4.0 cm(Q_(1)~Q_(3):2.9~6.3 cm)。肿瘤TNM分期:pT_(1)期52例,pT_(2)期7例,pT_(3)期10例及pT_(4)期1例,Ⅰ型及Ⅱ型患者肿瘤直径(4.0 cm vs 4.0 cm)及pT分期差异无统计学意义。Ⅰ型患者中1例伴癌栓,Ⅱ型患者中9例伴癌栓,7例淋巴结转移患者均为Ⅱ型。肿瘤侵犯肾包膜34例,含31例Ⅱ型(P<0.001),Ⅱ型患者WHO/ISUP分级显著高于Ⅰ型(P<0.001)。总体中位随访时间46个月,Ⅰ型和Ⅱ型pRCC患者中位随访时间分别为43个月和51个月。5年无进展生存率分别为100%和67.3%,Kaplan-Meier生存分析示Ⅰ型pRCC患者PFS优于Ⅱ型(P<0.05)。Cox多因素分析发现肿瘤直径与pRCC的PFS相关,此外术前碱性磷酸酶异常亦与Ⅱ型pRCC的PFS相关。结论Ⅱ型pRCC较Ⅰ型核分级更高,更易发生包膜入侵,更易发生疾病进展。直径较大的pRCC患者预后更差,术前碱性磷酸酶异常是Ⅱ型pRCC的独立危险因素。展开更多
基金supported by the fund of State Key Laboratory of Long-life High Temperature Materials(Grant No.DTCC28EE200787)the Natural Science Basic Research Plan in Shaanxi Province of China(Grant No.2022JQ-553)+3 种基金the China Postdoctoral Science Foundation(Grant No.2021M692555)the Excellent Youth Foundation of Shaanxi Province of China(Grant No.2021JC-08)the Beilin district of Xi’an Science and Technology Project(Grant No.GX2123)the support from the Youth Innovation Team of Shaanxi Universities。
文摘The oxidation behavior of a novel Ni-based single-crystal 4774DD1 superalloy for industrial gas turbine applications was investigated by the isothermal oxidation at 980℃ and discontinuous oxidation weight gain methods.The phase constitution and morphology of surface oxides and the characteristics of the crosssection oxide film were analyzed by XRD,SEM and EDS.Results show that the oxidation kinetics of the 4774DD1 superalloy follows the cubic law,indicating its weak oxidation resistance at this temperature.As the oxidation time increases,the composition of the oxide film evolves as following:One layer consisting of a bottom Al_(2)O_(3)sublayer and an upper(Al_(2)O_(3)+NiO)mixture sublayer after oxidized for 25 h.Then,two layers composed of an outermost small NiO discontinuous grain layer and an internal layer for 75 h.This internal layer is consisted of the bottom Al_(2)O_(3)sublayer,an intermediate narrow CrTaO_(4)sublayer,and an upper(Al_(2)O_(3)+NiO)mixture sublayer.Also two layers comprising an outermost relative continuous NiO layer with large grain size and an internal layer as the oxidation time increases to 125 h.This internal layer is composed of the upper(Al_(2)O_(3)+NiO)mixture sublayer,an intermediate continuous(CrTaO_(4)+NiWO_(4))mixture sublayer,and a bottom Al_(2)O_(3)sublayer.Finally,three layers consisting of an outermost(NiAl2O_(4)+NiCr2O_(4))mixture layer,an intermediate(CrTaO_(4)+NiWO_(4))mixture layer,and a bottom Al_(2)O_(3)layer for 200 h.
基金Supported by Key Clinical Projects of Peking University Third Hospital,No. BYSYZD2021013Beijing Haidian District Innovation and transformation project,No. HDCXZHZB2021202。
文摘BACKGROUND Cervical haemorrhage due to spontaneous rupture of a parathyroid adenoma is a rare complication that may cause life-threatening acute airway compromise.CASE SUMMARY A 64-year-old woman was admitted to the hospital 1 day after the onset of right neck enlargement, local tenderness, head-turning difficulty, pharyngeal pain, and mild dyspnoea. Repeat routine blood testing showed a rapid decrease in the haemoglobin concentration, indicating active bleeding. Enhanced computed tomography images showed neck haemorrhage and a ruptured right parathyroid adenoma. The plan was to perform emergency neck exploration, haemorrhage removal, and right inferior parathyroidectomy under general anaesthesia. The patient was administered 50 mg of intravenous propofol, and the glottis was successfully visualised on video laryngoscopy. However, after the administration of a muscle relaxant, the glottis was no longer visible and the patient had a difficult airway that prevented mask ventilation and endotracheal intubation. Fortunately, an experienced anaesthesiologist successfully intubated the patient under video laryngoscopy after an emergency laryngeal mask placement. Postoperative pathology showed a parathyroid adenoma with marked bleeding and cystic changes. The patient recovered well without complications.CONCLUSION Airway management is very important in patients with cervical haemorrhage. After the administration of muscle relaxants, the loss of oropharyngeal support can cause acute airway obstruction.Therefore, muscle relaxants should be administered with caution. Anaesthesiologists should pay careful attention to airway management and have alternative airway devices and tracheotomy equipment available.
基金Supported by the National Natural Science Foundation of China(61671193)Science and Technology Program of Zhejiang Province(2018C04012,2017C33049)Science and Technology Platform Construction Project of Fujian Science and Technology Department(2015Y2001)
文摘In stroke rehabilitation,rehabilitation equipments can help with the training.But traditional equipments are not convenient to carry,which limits patients to use related rehabilitation techniques.To solve this kind of problem,a new embedded rehabilitation system based on brain computer interface(BCI)is proposed in this paper.The system is based on motor imagery(MI)therapy,in which electroencephalogram(EEG)is evoked by grasping motor imageries of left and right hands,then collected by a wearable device.The EEG is transmitted to a Raspberry Pie processing unit through Bluetooth and decoded as the instructions to control the equipment extension.Users experience the limb movement through the visual feedback so as to achieve active rehabilitation.A pilot study shows that the user can control the movement of the rehabilitation equipment through his mind,and the equipment is convenient to carry.The study provides a new way to stroke rehabilitation.
基金the support of National Natural Science Foundation of China (Nos. 22172020 and 61974020)supported by the projects of Sci & Tech planning of Zhuhai City (No. ZH22017001200032PWC)。
文摘BACKGROUND: The study aims to investigate the occurrence of post-traumatic stress disorder(PTSD) after earthquakes among the elderly. METHODS: Data from cross-sectional studies focusing on the prevalence of PTSD after earthquakes among the elderly were collected from Pub Med, EMBASE, Cochrane Library, and China National Knowledge Infrastructure in December 2019. The search terms included post-traumatic stress disorder, earthquake, and elderly. This study used Review Manager 5.0 to evaluate the impact of the results. In addition, forest plots, sensitivity analysis, and bias analysis were carried out on the included articles. The combined estimate of the risk ratio and the standard deviation of the 95% confidence interval(95% CI) were measurements of the size of the effect.RESULTS: There were 4,834 patients included from 10 eligible studies. The sample sizes of PTSD group and non-PTSD group were 1,277 and 3,557, respectively. The meta-analysis showed that the overall occurrence of PTSD after earthquakes among the elderly was 0.25;the occurrence in females was higher than that in males, and the occurrence in the same province indicated little difference(Wenchuan city 0.25 and Ya'an city 0.24).CONCLUSIONS: After earthquakes, the occurrence of PTSD is higher among the elderly than among other age groups, and higher among the females than among the males, while there is little difference among different areas within the same province. This indicated that prioritized specific psychological interventions should be provided to the aged and the females.
基金This work was supported by the National Natural Science Foundation of China“Study on the dynamic mechanism of grassland ecosystem response to climate change in Qinghai Plateau”under grant number U20A2098the Second Tibet Plateau Scientific Expedition and Research Program(STEP)under grant number 2019QZKK0804.
文摘Accumulated temperature,which is now widely used in agronomy,is an important ecological factor to the growth of plants,but few relative studies have been found on the vegetation area of floodplain grasslands in Poyang Lake.This research used the classification and regression tree(CART)to classify normalized vegetation area index derived from MODIS LAI(Moderate Resolution Imaging Spectroradiometer Leaf Area Index)images from 2008 to 2014,according to different climate indexes,such as mean daily air temperature(n),accumulated temperature(jw),daily maximum temperature(g),daily minimum temperature(d),accumulative precipitation(j),water level(s)and average water level for 20 days preceding(a).The results showed that:(1)The accumulated temperature and the 20-day average WL(water level)were found to have the greatest impact on variation in wetland vegetation area,and they both dominated the classification process twice;(2)Two classification thresholds of accumulated temperature were 790°C and 1784°C,approximately corresponding to the beginning of April and midMay;(3)790°C could also be used as a threshold to select remote sensing images to analysis the annual variability of vegetation,i.e.while accumulated temperature is lower than 790°C,remote sensing images of similar accumulated temperature rather than similar date should be selected from different years for comparison.We also found that,effects of different hydrological factors on area of floodplain grasslands showed stage characteristics:(1)From January to March,water level changes slowly with less rainfall,as a result,the 20-day average WL which can interpret the hydrologic characteristics smoothly showed significant importance in this stage;(2)While entering April,intense rainfall make accumulative precipitation to be the dominating factor of classification;(3)From late April to mid-May,in condition of accumulative precipitation higher than 405 mm,daily water level is of most importance,because to the flood recession process as well as rapid water level fluctuations.
基金supported by the National Natural Science Foundation of China(Grant Nos.52002372,51672279,51727806,11874361,and 11774354)Science Challenge Project(Grant No.TZ2016001)Chinese Academy of Sciences Innovation Grant(Grant No.CXJJ-19-B08)。
文摘The recent discovery of room temperature superconductivity(283 K)in carbonaceous sulfur hydride(C-S-H)has attracted much interest in ternary hydrogen rich materials.In this report,ternary hydride P-S-H was synthesized through a photothermal-chemical reaction from elemental sulfur(S),phosphorus(P)and molecular hydrogen(H_(2))at high pressures and room temperature.Raman spectroscopy under pressure shows that H_(2)S and PH_(3) compounds are synthesized after laser heating at 0.9 GPa,and a ternary van der Waals compound P-S-H is synthesized with further compression to 4.6 GPa.The P-S-H compound is probably a mixed alloy of PH_(3) and(H_(2)S)_(2)H_(2) with a guest-host structure similar to the C-S-H system.The ternary hydride can persist up to 35.6 GPa at least and shows two phase transitions at approximately 23.6 GPa and 32.8 GPa,respectively.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.52002372,12004387,51672279,51727806,11874361,and 11774354))Science Challenge Project(Grant No.TZ2016001)the CASHIPS Director’s Fund(Grant No.YZJJ201705)。
文摘The layered van der Waals antiferromagnetic Fe PS_(3) has received considerable attention because long range magnetic ordering can remain with single atoms layer,which offers potential applications in future ultrathin devices.Here,we perform Raman spectroscopy to systematically explore the variations of lattice vibration and crystal structure under pressure up to 18.9 GPa.We observe two structural phase transitions at approximately 4 GPa and 13 GPa,respectively.Moreover,by monitoring spin-related Raman modes,we demonstrate a pressure-induced magnetic structure transition above 2 GPa.These modes disappear accompanying the second structural phase transition and insulator-to-metal transition(IMT),indicating the suppression of long-range magnetic ordering,in agreement with earlier neutron powder diffraction experiments.
基金supported by NSFC with grant No.62076083Firstly,the authors would like to express thanks to the Key Laboratory of Brain Machine Collaborative Intelligence of Zhejiang Province with grant No.2020E10010Industrial Neuroscience Laboratory of Sapienza University of Rome.
文摘Cognitive state detection using electroencephalogram(EEG)signals for various tasks has attracted significant research attention.However,it is difficult to further improve the performance of crosssubject cognitive state detection.Further,most of the existing deep learning models will degrade significantly when limited training samples are given,and the feature hierarchical relationships are ignored.To address the above challenges,we propose an efficient interpretation model based on multiple capsule networks for cross-subject EEG cognitive state detection,termed as Efficient EEG-based Multi-Capsule Framework(E3GCAPS).Specifically,we use a selfexpression module to capture the potential connections between samples,which is beneficial to alleviate the sensitivity of outliers that are caused by the individual differences of cross-subject EEG.In addition,considering the strong correlation between cognitive states and brain function connection mode,the dynamic subcapsule-based spatial attention mechanism is introduced to explore the spatial relationship of multi-channel 1D EEG data,in which multichannel 1D data greatly improving the training efficiency while preserving the model performance.The effectiveness of the E3GCAPS is validated on the Fatigue-Awake EEG Dataset(FAAD)and the SJTU Emotion EEG Dataset(SEED).Experimental results show E3GCAPS can achieve remarkable results on the EEG-based cross-subject cognitive state detection under different tasks.
基金Supported by The Special Research Foundation of the National Nature Science Foundation of China,No.81972262 and No.81972255The Guangdong Basic and Applied Basic Research Foundation,No.2018A030313645,No.2020A1515010117 and No.2016A030313840+4 种基金Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology,No.[2013]163the Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes,No.KLB09001Guangdong Science and Technology Department,No.2015B050501004Guangdong Science and Technology Department,No.2017B030314026Sun Yat-sen University Clinical Research 5010 Program,No.2018008.
文摘BACKGROUND Recurrent hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus is a great challenge for oncologists and has a poor prognosis.To date,the safety and efficacy of programmed cell death ligand 1(PD-L1)inhibitors are still unknown.CASE SUMMARY A 59-year-old male was identified as having a tumor thrombus in the inferior vena cava 3 years after surgery.The patient underwent a second surgery and adjuvant chemotherapy.However,the level of alpha-fetoprotein was elevated after 2 mo,and lung metastases and mediastinal lymph node metastases were identified.The expression of PD-L1 in HCC and inferior vena cava tumor thrombus tissues was analyzed by immunohistochemistry.Then,the patient received atezolizumab immunotherapy.The level of alpha-fetoprotein dropped to normal,the mediastinal lymph node metastases decreased in size and the lung metastases disappeared after 3 mo of immunotherapy.The patient had no signs of recurrence at 21 mo of follow-up.A 60-year-old male underwent left hepatic tumor resection,inferior vena cava incision and thrombus removal,followed by regular chemotherapy.The patient developed lung and splenic metastases after surgery.Pembrolizumab was used for six courses,and the splenic metastasis shrank,after which splenectomy was performed.The patient continued to receive pembrolizumab for thirteen courses,and the lung metastases showed no progression.A 34-year-old male was diagnosed with liver cancer with inferior vena cava tumor thrombus.The patient underwent right hepatectomy and received tislelizumab for three courses.He is still receiving immunotherapy and in good condition.CONCLUSION Anti-PD-L1 therapy in HCC patients with inferior vena cava tumor thrombus and metastasis is associated with relatively good patient outcomes.
基金supported by Guangdong Philosophy and Social Sciences Funding(GD21CXL03).
文摘Background:The coronavirus(COVID-19)outbreak in 2019 triggered psychological and emotional responses.This research investigates the psychological status and emotional problems of those who sought psychological assistance during the epidemic period by calling a mental health hotline.Methods:This study aims to combine qualitative and quantitative research.Descriptive analysis was used for undertaking qualitative research.We ana-lyzed the data from group 1(n=706),in which the people used the mental health hotline from 25 January 2020 to 23 June 2020.A self-designed questionnaire was developed in accordance with the classification and sum-marized items from group 1’s psychological problems and emotional status.To implement the quantitative research,we conducted a cross-sectional descriptive survey and used the self-compiled scale and HADS to inves-tigate group 2(n=553)from May 2020 to June 2020.Results:Descriptive statistics and comparative analysis revealed that:①Visitors mainly reported behavior,emotional,family relationship problems and sleep disorders.②Anxiety,comorbidities,sleep disorders and coping problems were the most frequently reported problems.③There were significant differences in the number of visitors experiencing various problems or exhibiting harmful behaviors(sorrow,worry,fear,depression,sleep disorders,self-harm or suicide,and coping problems,anxiety,hypochondria,and comorbidity)in the four stages of the epidemic.④More than a quarter of participants still suffered from anxiety or depression in the later stages of the epidemic.Conclusion:Different problems manifested at different stages of the epidemic,and psychological interventions and assistance should be tailored to reflect this.
文摘目的分析不同分型乳头状肾细胞癌(pRCC)的临床特征及治疗效果,探讨pRCC预后相关危险因素。方法回顾性收集了中山大学孙逸仙纪念医院2011年1月至2021年10月经微创手术治疗且病理确诊的70例pRCC患者的临床及病理资料。所有患者术前已排除远处转移,并对患者生存及复发转移情况进行跟踪随访,随访至2021年12月底,以出现疾病进展或任何原因的死亡为终点。采用Kaplan-Meier法绘制生存曲线,COX回归用于多因素分析无进展生存(PFS)的危险因素。结果70例患者均诊断为pRCC,包括21例Ⅰ型及49例Ⅱ型,其中男55例,中位年龄57岁。中位肿瘤直径为4.0 cm(Q_(1)~Q_(3):2.9~6.3 cm)。肿瘤TNM分期:pT_(1)期52例,pT_(2)期7例,pT_(3)期10例及pT_(4)期1例,Ⅰ型及Ⅱ型患者肿瘤直径(4.0 cm vs 4.0 cm)及pT分期差异无统计学意义。Ⅰ型患者中1例伴癌栓,Ⅱ型患者中9例伴癌栓,7例淋巴结转移患者均为Ⅱ型。肿瘤侵犯肾包膜34例,含31例Ⅱ型(P<0.001),Ⅱ型患者WHO/ISUP分级显著高于Ⅰ型(P<0.001)。总体中位随访时间46个月,Ⅰ型和Ⅱ型pRCC患者中位随访时间分别为43个月和51个月。5年无进展生存率分别为100%和67.3%,Kaplan-Meier生存分析示Ⅰ型pRCC患者PFS优于Ⅱ型(P<0.05)。Cox多因素分析发现肿瘤直径与pRCC的PFS相关,此外术前碱性磷酸酶异常亦与Ⅱ型pRCC的PFS相关。结论Ⅱ型pRCC较Ⅰ型核分级更高,更易发生包膜入侵,更易发生疾病进展。直径较大的pRCC患者预后更差,术前碱性磷酸酶异常是Ⅱ型pRCC的独立危险因素。
基金supported by the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK0304-02)Joint Chinese Academy of Sciences(CAS)-Max Planck Society(MPG)Research Project(HZXM20225001MI)+3 种基金the Strategic Priority Research Program A of Chinese Academy of Sciences(XDA20050104)the National Natural Science Foundation of China(42041005)CAS Light of West China Programthe Fundamental Research Funds for the Central Universities。