基于深度学习模型的非小细胞肺癌新辅助免疫联合化疗疗效预测

目的:基于深度学习算法,使用临床数据构建人工智能(artificial intelligence,AI)模型,评估其预测非小细胞肺癌(nonsmall cell lung cancer,NSCLC)新辅助免疫联合化疗疗效的可行性。方法:收集2020年1月至2024年1月于首都医科大学附属北京胸科医院确诊且接受新辅助免疫联合化疗的132例NSCLC患者的临床病理数据。对影响新辅助免疫联合化疗疗效的主要因素进行统计学分析。根据统计学分析结果以及查阅相关文献对变量进行筛选,构建变量数据集。基于多层感知机(multi-layer perceptron,MLP)算法采用5折交叉验证建立深度学习模型,应用接收者操作特征(receiver operating characteristic,ROC)曲线评估模型性能。结果:132例患者中单因素分析显示获得主要病理缓解(major pathological response,MPR)组与未获得MPR组的患者在性别(P=0.020)、吸烟史(P=0.004)、癌胚抗原(carcinoembryonic antigen,CEA)(P=0.038)及程序性死亡配体-1(programmed death-ligand 1,PD-L1)是否≥1%(P=0.038)方面差异具有统计学意义;获得完全病理缓解(complete pathological response,pCR)组与未获pCR组患者在肿瘤大小是否≤3 cm(P=0.007)和CEA水平方面(P=0.010)差异具有统计学意义。经5折交叉验证后,MPR预测模型在验证集和测试集的平均受试者工作特征曲线下面积(area under the curve,AUC)值分别为0.72及0.71。结论:该深度学习模型能够有效预测NSCLC患者新辅助免疫联合化疗疗效。

显花植物自交不亲和性的分子与演化机制

自交不亲和性(self-incompatibility, SI)是雌雄同花植物广泛采取的一种种内促进异交机制,通常由一个多态且复等位的S位点控制。目前共发现6种不同分子机制的SI,包括由花柱S因子S-RNase和花粉S因子SLFs控制且常见于车前科、茄科、蔷薇科和芸香科的I类、SRK和SCR控制的十字花科II类、PrsS和PrpS控制的罂粟科III类、CYP-GLO2-KFB-CCM-PUM控制的报春花科IV类、TsSPH1-TsYUC6-TsBAHD控制的时钟花科V类及HPS10-S和DUF247I-S控制的禾本科VI类SI,其中I类SI为异己识别体系,而II、III和VI类均为自己识别系统。此外,近年来对其起源和演化机制研究也取得显著进展。其中,I类SI起源于真双子叶植物的最近共同祖先,II~V类则为丢失I类后分别进化产生的新机制,而单子叶禾本科特有的VI类SI则可能是在丢失古老I类SI后演化出的新系统。本文主要总结已报道SI的分子和演化机制,以期为显花植物SI的理论研究和育种应用提供参考和帮助。

Morpho-cultural, Pathogenicity and Molecular Characterization of Phyllosticta capitalensis Inciting Cavendish Banana Freckle Disease in Hainan

[Objectives]The study was to identify the casual agent of freckle disease on Cavendish banana in Hainan Province,China.[Methods]Fungal isolates were isolated from affected leaf tissues and identified by the morphological features,molecular identification and pathogenicity test.[Results]The fungus isolated from affected leaf tissues was identified as Phyllosticta capitalensis based on the morphological properties of the colony and spore,coupled with sequence analyses of the internal transcribed spacer(ITS)region and the large subunit(LSU)rDNA gene.Koch s postulates were fulfilled by successfully re-isolating the pathogen from the artificial inoculated leaves.[Conclusions]P.capitalensis is a new pathogen responsible for Cavendish banana freckle disease in Hainan.

Dynamic plugging regulating strategy of pipeline robot based on reinforcement learning

Pipeline isolation plugging robot (PIPR) is an important tool in pipeline maintenance operation. During the plugging process, the violent vibration will occur by the flow field, which can cause serious damage to the pipeline and PIPR. In this paper, we propose a dynamic regulating strategy to reduce the plugging-induced vibration by regulating the spoiler angle and plugging velocity. Firstly, the dynamic plugging simulation and experiment are performed to study the flow field changes during dynamic plugging. And the pressure difference is proposed to evaluate the degree of flow field vibration. Secondly, the mathematical models of pressure difference with plugging states and spoiler angles are established based on the extreme learning machine (ELM) optimized by improved sparrow search algorithm (ISSA). Finally, a modified Q-learning algorithm based on simulated annealing is applied to determine the optimal strategy for the spoiler angle and plugging velocity in real time. The results show that the proposed method can reduce the plugging-induced vibration by 19.9% and 32.7% on average, compared with single-regulating methods. This study can effectively ensure the stability of the plugging process.

Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver disease.However,the disease is underappreciated as a remarkable chronic disorder as there are rare managing strategies.Several studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic options.Pyroptosis,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular characteristics.Considering the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the disease.The study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic approaches.Nevertheless,further studies are necessary.

Improved Convolutional Neural Network for Traffic Scene Segmentation

In actual traffic scenarios,precise recognition of traffic participants,such as vehicles and pedestrians,is crucial for intelligent transportation.This study proposes an improved algorithm built on Mask-RCNN to enhance the ability of autonomous driving systems to recognize traffic participants.The algorithmincorporates long and shortterm memory networks and the fused attention module(GSAM,GCT,and Spatial Attention Module)to enhance the algorithm’s capability to process both global and local information.Additionally,to increase the network’s initial operation stability,the original network activation function was replaced with Gaussian error linear unit.Experiments were conducted using the publicly available Cityscapes dataset.Comparing the test results,it was observed that the revised algorithmoutperformed the original algorithmin terms of AP_(50),AP_(75),and othermetrics by 8.7%and 9.6%for target detection and 12.5%and 13.3%for segmentation.

Enhancing Log Anomaly Detection with Semantic Embedding and Integrated Neural Network Innovations

System logs,serving as a pivotal data source for performance monitoring and anomaly detection,play an indispensable role in assuring service stability and reliability.Despite this,the majority of existing log-based anomaly detection methodologies predominantly depend on the sequence or quantity attributes of logs,utilizing solely a single Recurrent Neural Network(RNN)and its variant sequence models for detection.These approaches have not thoroughly exploited the semantic information embedded in logs,exhibit limited adaptability to novel logs,and a single model struggles to fully unearth the potential features within the log sequence.Addressing these challenges,this article proposes a hybrid architecture based on amultiscale convolutional neural network,efficient channel attention and mogrifier gated recurrent unit networks(LogCEM),which amalgamates multiple neural network technologies.Capitalizing on the superior performance of robustly optimized BERT approach(RoBERTa)in the realm of natural language processing,we employ RoBERTa to extract the original word vectors from each word in the log template.In conjunction with the enhanced Smooth Inverse Frequency(SIF)algorithm,we generate more precise log sentence vectors,thereby achieving an in-depth representation of log semantics.Subsequently,these log vector sequences are fed into a hybrid neural network,which fuses 1D Multi-Scale Convolutional Neural Network(MSCNN),Efficient Channel Attention Mechanism(ECA),and Mogrifier Gated Recurrent Unit(GRU).This amalgamation enables themodel to concurrently capture the local and global dependencies of the log sequence and autonomously learn the significance of different log sequences,thereby markedly enhancing the efficacy of log anomaly detection.To validate the effectiveness of the LogCEM model,we conducted evaluations on two authoritative open-source datasets.The experimental results demonstrate that LogCEM not only exhibits excellent accuracy and robustness,but also outperforms the current mainstream log anomaly detection methods.

Clinical characteristics of patients with early gastric prematurity cancer and analysis of complications by endoscopic resection

BACKGROUND Gastric cancer,a prevalent malignancy,poses a severe threat to the health of residents in China.Timely intervention in early stages can extend patients’survival.AIM To analyze clinical characteristics of patients with early gastric cancer and efficacy and risk of complications associated with endoscopic resection.METHODS This study included 175 patients with early gastric cancer treated at our hospital,with no restrictions on sex or age.General data,pathological information,and endoscopic biopsy results were obtained.The clinical characteristics of early gastric cancer were analyzed,and endoscopic resection was performed.Postoperative efficacy and incidence of complications were monitored.Statistical analysis was performed using SPSS 26.0 and GraphPad Prism 8.0 software.RESULTS A total of 175 patients with early gastric cancer were included,with 75.43%(n=132)males and 24.57%(n=43)females.38.29%(n=67)and 35.43%(n=62)of patients had a history of smoking and alcohol consumption,respectively.Comorbidities included diabetes(8.57%,n=15),coronary heart disease(10.29%,n=18),and hypertension(43.43%,n=76),which was highly prevalent.A history of abdominal surgery and family history of digestive system cancer accounted for 21.14%and 17.14%,respectively.The most common lesion location was the antral part of the stomach(52.00%,n=91),followed by the gastric angle,body,and fundus.The pathological types were predominantly high-grade intraepithelial neoplasia(28.00%,n=49)and well-differentiated adenocarcinoma(26.86%,n=47),followed by moderately differentiated adenocarcinoma,high-moderately differentiated adenocarcinoma,and moderate-lowly differentiated adenocarcinoma.89.14%of the patients had intestinal metaplasia and 85.14%had atrophy.After endoscopic resection,re-examination revealed that 13 patients had cancer cells at the tissue margin,with a positive margin rate of 7.43%.Postoperative complications included no cases of gastrointestinal obstruction,but incisional infection(2.86%,n=5),gastric perforation(1.14%,n=2),and gastric bleeding(4%,n=7)were present,with an overall incidence of 8.00%.CONCLUSION Analysis of the clinical characteristics indicated that early gastric cancer is more prevalent in males with a history of hypertension,with lesions most commonly occurring in the antral region of the stomach.The pathological types are often high-grade intraepithelial neoplasia and well-differentiated adenocarcinoma,with over 85%of patients having comorbid intestinal metaplasia and atrophy.Despite endoscopic resection,a positive margin rate persisted,indicating a probability of residual cancer at the margins.Postoperative complications,such as gastrointestinal obstruction,incisional infection,gastric perforation,and gastric bleeding can occur and require timely symptomatic treatment.

Clinical analysis of Klebsiella pneumoniae infection in patients with liver cirrhosis in Beijing

BACKGROUND The incidence of Klebsiella pneumoniae(K.pneumoniae)infection in patients with cirrhosis has been increasing over recent years,posing certain difficulties in clinical treatment.AIM To analyze the clinical features of patients with liver cirrhosis and identify the risk factors to help the early diagnosis and treatment of these diseases.METHODS Clinical data and laboratory tests were collected from 72 patients with cirrhosis confirmed by secretion or blood culture of K.pneumoniae infection at Beijing Ditan Hospital,Capital Medical University,between May 2016 and October 2018.Data from hospitalized patients with liver cirrhosis and K.pneumoniae infections,in-cluding age,sex,antimicrobial use,length of stay,site of infection,distribution of pathogenic bacteria,complications,invasive operations,laboratory indicators,treatment,and clinical regression,were extracted and retrospectively analyzed.Clinical data and biochemical values were included in the multivariate logistic regression analysis.RESULTS A total of 52 men and 20 women,with an age range from 29 to 85 years and an average age of 57.7±12.54,were analyzed.The incidence of hospital K.pneu-moniae infection in patients with cirrhosis was approximately 19.44%.The most common the infection site was the bloodstream,followed by the respiratory tract,abdominal cavity,and biliary tract.Risk factors for infection were old age,long hospital stays,gastrointestinal bleeding,and low serum albumin levels,while prophylactic antibiotics were protective factors.The multivariate analysis suggested that other infections,chronic diseases,and invasive procedures were independent factors.CONCLUSION In clinical practice,the length of hospital stays should be shortened as much as possible,invasive operations should be reduced,antibiotics should be rationally used,and the patients’liver function should be timely improved.This is of great significance for reducing the incidence of hospital infection.

Biological Characteristics of the Pathogen Phyllosticta capitalensis Causing Banana Freckle Disease in Hainan Province

[Objectives]This study was conducted to clarify the biological characteristics of the pathogen Phyllosticta capitalensis,the causal agent of freckle disease on Cavendish banana in Hainan Province,China.[Methods]The impact of various nutritional and environmental factors,including media,carbon sources,nitrogen sources,temperature,pH and light on the growth and sporulation of P.capitalensis was assessed using two distinct methods:mycelium growth rate and blood counting chamber.[Results]The mycelial growth and sporulation of P.capitalensis on different media exhibited notable differences.The use of banana leaf extract dextrose agar(BLEAD)and carrot agar(CA)was observed to facilitate rapid mycelial growth.The potato dextrose agar(PDA)and potato sucrose agar(PSA)were conducive to the production of conidia.The utilization of distinct carbon and nitrogen sources exerted a pronounced influence on the growth of P.capitalensis.Maltose,dextrose,fructose,and casein acid hydrolysate were the preferred substrates for mycelial growth.The tested carbon and nitrogen sources did not significantly stimulate conidial production,whereas dextrose and NaNO 3 were found to favor sporulation.The optimal temperature for mycelial growth and conidial production was determined to be 28 and 32℃,respectively.No mycelial growth was observed at 5℃.Active mycelial growth was observed at pH 6-10,with pH 6-7 being particularly conducive to sporulation.Complete darkness was conducive to mycelial growth and sporulation.[Conclusions]It is recommended that BLEDA and PDA should be incubated at 28℃for 14 d in the dark for the purpose of mycelial growth and sporulation of P.capitalensis,respectively.

弹性体/聚丙烯与塑性体/聚丙烯复合材料的力学及介电性能

选用聚丙烯(PP)为基体树脂,分别以乙烯-辛烯共聚弹性体(POE)、丙烯-乙烯共聚塑性体(POP)为填料,制备出不同组分的POE/PP与POP/PP共混材料。对共混体系的力学性能研究表明,POP在降低PP弹性模量及增韧改性效果上均弱于同含量的POE/PP体系,但当POP质量分数增至40%时与POE质量分数为30%时的力学性能相仿;而电导电流及交、直流击穿等实验表明,POP较POE更大程度维持了纯PP的电性能;观测共混体系的微观形态发现POE在PP中的分散性较差,而共聚单体含量较少的POP对PP结晶规整度破坏较弱,相近分子结构呈现出与PP较好的相容性,是POP/PP体系电性能较优异的原因,具有潜在的工程应用价值。

飞秒激光微切口角膜基质透镜取出术术后并发症分析及处理

目的:分析飞秒激光微切口角膜基质透镜取出术(small incision lenticule extraction,SMILE)术后并发症,探讨其发生的原因、处理对策及对预后的影响。方法:回顾性分析我院2016-06/2017-05进行的SMILE患者1127例2236眼的临床资料,随访时间为6mo。结果:术后并发症总体发生率为8.05%,包括弥漫性层间角膜炎74眼(3.31%)、视力恢复延迟58眼(2.59%)、角膜层间异物残留14眼(0.63%)、视物重影34眼(1.52%)。1眼存在严重偏中心切削者术后3mo视力尚未恢复,行角膜地形图引导的准分子激光上皮下角膜磨镶术(laser-assisted subepithelial keratomileusis,LASEK)。所有患者并发症经适当处理后结果良好,术后裸眼视力均达到或超过术前最佳矫正视力。结论:尽管SMILE存在一定比例术后并发症,但手术总体是安全的。术中注意手术技巧,调整手术参数,术后合理用药可以减少并发症的发生。

结晶特性对聚丙烯空间电荷及直流击穿强度影响

采用扫描电子显微镜、偏光显微镜和差示扫描量热法观察了不同成形条件聚丙烯(PP)的结晶形态及结晶度,通过动态力学热分析(DMA)测试了不同结晶形态PP的力学特性,利用电声脉冲法(PEA)测得不同结晶形态PP的空间电荷特性,并对不同结晶形态PP进行了直流击穿强度测试。结果表明,PP在较高的熔融温度和结晶温度下减少了晶核数目并促进了球晶生长。DMA和PEA测试表明,小球晶可使PP的储存模量降低,大球晶在生长过程中,将较多的杂质和低分子物排挤到无定形区中,导致β松弛损耗增大,从而使室温下的空间电荷量明显增加。直流击穿强度测试表明,当PP形成大且疏的球晶时,击穿过程可沿更短的路径发展,并且无定形区存在较多杂质及低分子物,从而使击穿强度明显降低。

ARMD出血患者血清miR-27a和NRF2的表达与预后的相关性

目的:检测年龄相关性黄斑变性(ARMD)出血患者血清微小RNA-27a(miR-27a)和转录因子E2相关因子(NRF2)的表达情况,并研究其相对表达量与ARMD出血患者预后的相关性。方法:采用回顾性病例对照研究,收集2018-06/2019-10在本院眼科确诊并治疗的ARMD出血患者80例为ARMD出血组,选取同期在本院进行常规检查的健康受试者80例为对照组。采用实时荧光定量PCR法(qRT-PCR)检测所有研究对象血清miR-27a和NRF2相对表达量;通过研究对象工作特征曲线(ROC)评估血清miR-27a和NRF2相对表达量对ARMD出血的诊断价值;分析患者预后不良情况发生率;采用Logistic回归分析ARMD出血患者预后不良的影响因素。结果:ARMD出血患者血清miR-27a相对表达量显著高于对照组(P<0.01),血清NRF2 mRNA相对表达量显著低于对照组(P<0.01)。ROC结果显示,血清miR-27a和NRF2诊断ARMD出血的AUC分别为0.867、0.820,截断值分别为1.10、1.08,此时对应灵敏度分别为71.3%、91.3%,特异性分别为90.0%、63.7%。血清miR-27a和NRF2联合检测ARMD出血的AUC为0.912,此时对应灵敏度和特异性分别为86.3%、85.0%。高miR-27a组患者预后不良发生率明显高于低miR-27a组(P<0.05);高NRF2组患者预后不良发生率显著低于低NRF2组(P<0.05)。Logistic分析显示,血清miR-27a高表达是影响ARMD出血患者发生预后不良的危险因素,血清NRF2高表达是影响ARMD出血患者发生预后不良的保护因素。结论:miR-27a在ARMD出血患者血清中的相对表达量明显升高,NRF2相对表达量明显降低,两者对ARMD出血具有一定诊断价值,且其表达情况与患者预后密切相关,提示血清miR-27a和NRF2可作为ARMD出血的早期诊断及预后评估的潜在生物学指标。

圆锥角膜患者角膜光密度与形态及生物力学的相关性研究

目的:探讨圆锥角膜患者角膜光密度与角膜形态参数及生物力学特性的相关性。方法:回顾性病例研究。收集2020-01/12在郑州市第二人民医院就诊的原发性圆锥角膜患者48例70眼,使用Pentacam眼前段分析系统测量角膜形态,包括角膜前表面中央扁平子午线曲率(K1)、角膜前表面陡峭子午线曲率(K2)、角膜前表面中央平均曲率(Km)、角膜前表面最大曲率(Kmax)、角膜前表面高度(ACE)、角膜后表面高度(PCE)、最薄点角膜厚度(TCT),以及圆锥锥顶距角膜顶点的距离(DCA)。测量不同分区不同层次的角膜光密度。使用可视化角膜生物力学测量仪观察角膜形变过程并测量相关参数,包括第一次压平时间(AT1),第一次压平长度(AL1),第一次压平速度(V1),第二次压平时间(AT2),第二次压平长度(AL2),第二次压平速度(V2),最大压陷时间(HCT),最大压陷形变幅度(HCDA),最大压陷曲率半径(HCR),最大压陷峰距(HCPD),硬度参数(SPA1),水平方向Ambrósio相关厚度(ARTh)。结果:圆锥角膜患者距角膜顶点≤2mm前层光密度与K1、K2、Km、Kmax均呈正相关(r=0.291、0.315、0.315、0.387;P=0.015、0.008、0.008、0.001)。距角膜顶点≤2mm、>2mm且≤6mm前层及全层、>2mm且≤6mm后层光密度与ACE均呈正相关(r=0.465、0.302、0.317、0.291、0.335;P<0.01、P=0.011、0.008、0.014、0.005);上述各区域各层的光密度与PCE均呈正相关(r=0.565、0.369、0.348、0.306、0.284;P<0.01、P=0.002、0.003、0.010、0.017)。距角膜顶点≤2mm前、中、后及全层光密度,>2mm且≤6mm中、后及全层光密度均与AL1均呈负相关(r=-0.284、-0.290、-0.245、-0.326、-0.282、-0.395、-0.310;P=0.017、0.015、0.041、0.006、0.018、0.001、0.009)。距角膜顶点≤2mm中层光密度、>2mm且≤6mm中、后层光密度与AL2呈负相关(r=-0.246、-0.256、-0.256;P=0.041、0.032、0.032)。距角膜顶点≤2mm前层光密度与HCR呈负相关(r=-0.308,P=0.010)。距角膜顶点≤2mm中、后层光密度、>2mm且≤6mm中层光密度与HCT均呈负相关(r=-0.292、-0.340、-0.262;P=0.014、0.004、0.028)。距角膜顶点≤2mm前层及全层光密度、>2mm且≤6mm后层光密度与ARTh呈负相关(r=-0.430、-0.293、-0.319;P<0.01,P=0.014、0.007)。结论:圆锥角膜患者角膜光密度测定值与角膜形态和生物力学特性相关,可能成为圆锥角膜的潜在诊断指标。

不同体位A超测量难测眼眼轴的对比研究

目的:通过比较患者难测眼的坐位、卧位A超和晶星900(Lenstar,LS900)三种方法测量眼轴长度的差异,为更准确进行难测眼眼轴测量提供指导。方法:临床病例对照研究。对2019-05/2020-09在郑州市第二人民医院就诊的合并硅油眼、玻璃体积血或视网膜脱离的白内障患者及晶状体或人工晶状体脱位的患者102例102眼分别行LS900及坐位、卧位A超检查测量眼轴长度,并对三种方法测量结果进行统计学分析。结果:LS900与A超眼轴测量检出率分别为83%和100%;A超坐位和卧位及LS900三种方法测量眼轴长度整体、硅油组、晶状体脱位组、玻璃体积血组比较均有差异(P<0.001),整体卧位、硅油组卧位、晶状体脱位组卧位、玻璃体积血组卧位与LS900测量值眼轴长度均值比较有差异(均P<0.05),而整体坐位和各难测眼组坐位与LS900测量眼轴长度比较均无差异;三种测量方法所测值在95%一致性范围内一致性良好,A超坐位测量结果更接近LS900。结论:在难测眼A超眼轴测量中,特别是眼部组织结构发生改变的疾病,改变常规卧位为坐位可提高测量结果的准确性,为临床医生制定治疗方案提供更可信的指导。

Research on Risk Assessment Method of Long-Tube Trailer Road Transportation

Road transport safety has always been paid attention to by the safety production managers of enterprises. In this study, cloud model and analytic hierarchy process were applied to the safety of long-tube trailer transport. The opinions of 30 experts were analyzed, from which 29 key parameters were selected. The study addressed the relevance of the parameters and the possibility of automatic collection and transmission to obtain 12 core risk factors. The macro-safety risk indicator system for long-tube trailers was established based on the identified risk indicators. Finally, a risk assessment model for road transport of long tube trailers consisting of 3 dimensions of likelihood, severity and sensitivity was constructed. This model provides a technical method for strengthening the risk control of road transport of long-tube trailers.

Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients

AIM To determine incidence and clinical biomarkers of marked necroinflammation and fibrosis characteristics among chronic hepatitis B (CHB) patients with persistently normal alanine aminotransferase (PNALT). METHODS Liver biopsy was performed on 115 CHB patients with PNALT. Necroinflammation and fibrosis were graded by the Knodell histologic activity index and the Ishak fibrosis score, respectively. Correlations between the available clinical parameters and necroinflammation and fibrosis were analysed. RESULTS Marked necroinflammation (Knodell activity index >= 7) and fibrosis (Ishak fibrosis score >= 3) were found in 36.5% and 15.5% of CHB patients with PNALT, respectively. Following a univariate logistic regression analysis, multiple logistic regression analysis indicated that aspartate transaminase (AST) (AUROC = 0.852, cut-off value = 22.5 U/L) serves as an independent predictor of notable liver inflammation, while platelet (PLT) count (AUROC = 0.905, cut-off value = 171.5 x 10(9)/ml) and gamma-glutamyl transpeptidase (GGT) (AUROC = 0.909, cut-off value = 21.5 U/L) level serve as independent predictors of notable liver fibrosis. CONCLUSION A considerable proportion of marked histological abnormalities existed in our cohort, who will benefit from optimal therapeutic strategies administered according to predictive indication by AST, PLT and GGT levels.

A pilot phase Ⅱ study of neoadjuvant triplet chemotherapy regimen in patients with locally advanced resectable colon cancer

Objective： This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer.Methods： Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen（oxaliplatin 85 mg/m2 and irinotecan 150 mg/m2, combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m2 by 44 h infusion or capecitabine 1 g/m2 or S-1 40–60 mg b.i.d orally d 1–10, repeated at 2-week intervals） for 4 cycles. Complete mesocolic excision was scheduled 2–6 weeks after completion of neoadjuvant treatment and followed by a further 6 cycles of FOLFOXIRI or XELOX. Primary outcome measures of this stage II trial were feasibility, safety, tolerance and efficacy of neoadjuvant treatment.Results： All 23 patients received neoadjuvant chemotherapy and underwent surgery. Twenty-one patients（91.3%） had reductions in tumor volume after neoadjuvant treatment, and 13 patients（56.5%） had grade 3–4toxicity. No patients had severe complications from surgery. Preoperative therapy resulted in significant downstaging of T-stage and N-stage compared with the baseline clinical stage including one pathological complete response.Conclusions： Neoadjuvant triple chemotherapy has high activity and acceptable toxicity and perioperative morbidity, and is feasible, tolerable and effective for locally advanced resectable colon cancer.

Detection of small hepatocellular carcinoma:Comparison of dynamic enhancement magnetic resonance imaging and multiphase multirow-detector helical CT scanning

AIM: To compare the gadolinium-enhanced multiphase dynamic magnetic resonance imaging (MRI) and multiphase multirow-detector helical CT (MDCT) scanning for detection of small hepatocellular carcinoma (HCC). METHODS: MDCT scanning and baseline MRI with SE T1-WI and T2-WI sequence combined with FMPSPGR sequence were performed in 37 patients with 43 small HCCs. Receiver operating characteristic (ROC) curves were plotted to analyze the results for modality. RESULTS: The areas below ROC curve (Az) were calculated. There was no statistical difference in dynamic enhancement MDCT and MRI. The detection rate of small HCC was 97.5%-97.6% on multiphase MDCT scanning and 90.7%-94.7% on MRI, respectively. The sensitivity of detection for small HCC on MDCT scanning was higher than that on dynamic enhancement MRI. The sensitivity of detection for minute HCC (tumor diameter ≤ 1 cm) was 90.0%-95.0% on MDCT scanning and 70.0%-85.0% on MRI, respectively. CONCLUSION: MDCT scanning should be performed for early detection and effective treatment of small HCC in patients with chronic hepatitis and cirrhosis during follow-up.