应用于孤岛型微电网以实现频率控制功能的传统控制器多为分数阶PID(fractional order PID,FOPID)控制器及模糊分数阶PID(fuzzy fractional order PID,FFOPID)控制器,二者的控制性能均存在局限性。针对这一问题,设计了一种变论域混合FFO...应用于孤岛型微电网以实现频率控制功能的传统控制器多为分数阶PID(fractional order PID,FOPID)控制器及模糊分数阶PID(fuzzy fractional order PID,FFOPID)控制器,二者的控制性能均存在局限性。针对这一问题,设计了一种变论域混合FFOPID控制器,用于提高孤岛微电网的频率控制性能。通过对比FOPID、FFOPID以及变论域混合FFOPID3种控制器作用时的不同效果,证明了变论域混合FFOPID控制器相比其他控制器对于孤岛微电网的频率控制有着更好的控制性能。同时考虑了反馈信号受到测量噪声干扰时对控制器的控制性能产生影响进而使得孤岛微电网频率波动增大的情况,并针对此问题使用了动态数据校正(dynamic datareconciliation,DDR)滤波技术。通过对比时域仿真中FOPID、FFOPID以及变论域混合FFOPID控制器各自作用时孤岛微电网频率偏差的输出结果,验证了DDR滤波技术对孤岛微电网的频率控制的显著效果。展开更多
为筛选高效、安全的防治炭疽病新药剂,通过田间试验进行新药剂筛选。试验结果表明:在药后的7天和14天,苯甲·嘧菌酯对苦瓜炭疽病的防效最好。与之相比较,在草莓和黄瓜上的防效也较为理想。研究表明,苯甲·嘧菌酯防治炭疽病效果...为筛选高效、安全的防治炭疽病新药剂,通过田间试验进行新药剂筛选。试验结果表明:在药后的7天和14天,苯甲·嘧菌酯对苦瓜炭疽病的防效最好。与之相比较,在草莓和黄瓜上的防效也较为理想。研究表明,苯甲·嘧菌酯防治炭疽病效果良好、持效期长,是防治草莓、苦瓜、黄瓜炭疽病的理想药剂,同时,还能防治草莓病害、提高产量、改善草莓品质。生产上建议的使用剂量为450~600 m L/hm^2。展开更多
Background Monoclonal antibodies （mAbs） such as DD3,raised against progastrin-releasing peptide（31-98） （ProGRP（31-98）） antigen,have been used to target small cell lung cancer （SCLC）.However,as an intact mAb,...Background Monoclonal antibodies （mAbs） such as DD3,raised against progastrin-releasing peptide（31-98） （ProGRP（31-98）） antigen,have been used to target small cell lung cancer （SCLC）.However,as an intact mAb,DD3 is cleared slowly from the body,with an optimal radioimmunoimaging time of 72 hours.More recently,a singlechain antibody fragment has demonstrated reduced excretion time in blood and normal tissues and is increasingly used in diagnostic cancer research.Thereby,it potentially increases the radioimmunoimaging efficacy.However,there have been few studies with this antibody fragment.The aim of this study was to characterize the preliminary radioimmunoimaging and biodistribution of 1311I-anti-ProGRP（31-98）scFv in nude mice bearing SCLC xenografts.Methods Anti-ProGRP（31-98） scFv was used to detect ProGRP expression by flow cytometry analysis and immunohistochemistry.131I-anti-ProGRP（31-98） scFv was injected intravenously into healthy Kunming mice and the percentage injected dose per gram （%ID/g） in various organs was calculated.Similarly,the %ID/g and tumor/non-tumor ratio in xenograft-bearing mice was calculated.After injection of 131I-anti-ProGRP（31-98） scFv,treated mice were imaged at 1,24,and 30 hours.Then the tumor/base ratios were calculated.Results ProGRP was highly expressed in NCI-H446 cells and xenograft tissue.The metabolism of 131I-anti-ProGRP（31-98） scFv in healthy mice was consistent with a first-order and two-compartment model; T1/2α and T1/2β were 10.2 minutes and 5 hours 18 minutes,respectively.The %ID/g of 131I-anti-ProGRP（31-98） scFv in xenografts was much higher than in healthy tissues at 12 hours after injection,reaching a maximum of （5.38±0.92） %ID/g at 24 hours.Successful imaging of xenograft tissue was achieved as early as 1 hour post-injection and persisted until 30 hours,with 24 hours proving optimal.Conclusion 131I-anti-ProGRP（31-98）scFv shows highly selective tumor uptake with low accumulation in normal tissues and rapid blood clearance,indicating thatit could be a promising agent for SCLC radioimmunoimaging.展开更多
文摘应用于孤岛型微电网以实现频率控制功能的传统控制器多为分数阶PID(fractional order PID,FOPID)控制器及模糊分数阶PID(fuzzy fractional order PID,FFOPID)控制器,二者的控制性能均存在局限性。针对这一问题,设计了一种变论域混合FFOPID控制器,用于提高孤岛微电网的频率控制性能。通过对比FOPID、FFOPID以及变论域混合FFOPID3种控制器作用时的不同效果,证明了变论域混合FFOPID控制器相比其他控制器对于孤岛微电网的频率控制有着更好的控制性能。同时考虑了反馈信号受到测量噪声干扰时对控制器的控制性能产生影响进而使得孤岛微电网频率波动增大的情况,并针对此问题使用了动态数据校正(dynamic datareconciliation,DDR)滤波技术。通过对比时域仿真中FOPID、FFOPID以及变论域混合FFOPID控制器各自作用时孤岛微电网频率偏差的输出结果,验证了DDR滤波技术对孤岛微电网的频率控制的显著效果。
文摘为筛选高效、安全的防治炭疽病新药剂,通过田间试验进行新药剂筛选。试验结果表明:在药后的7天和14天,苯甲·嘧菌酯对苦瓜炭疽病的防效最好。与之相比较,在草莓和黄瓜上的防效也较为理想。研究表明,苯甲·嘧菌酯防治炭疽病效果良好、持效期长,是防治草莓、苦瓜、黄瓜炭疽病的理想药剂,同时,还能防治草莓病害、提高产量、改善草莓品质。生产上建议的使用剂量为450~600 m L/hm^2。
文摘Background Monoclonal antibodies （mAbs） such as DD3,raised against progastrin-releasing peptide（31-98） （ProGRP（31-98）） antigen,have been used to target small cell lung cancer （SCLC）.However,as an intact mAb,DD3 is cleared slowly from the body,with an optimal radioimmunoimaging time of 72 hours.More recently,a singlechain antibody fragment has demonstrated reduced excretion time in blood and normal tissues and is increasingly used in diagnostic cancer research.Thereby,it potentially increases the radioimmunoimaging efficacy.However,there have been few studies with this antibody fragment.The aim of this study was to characterize the preliminary radioimmunoimaging and biodistribution of 1311I-anti-ProGRP（31-98）scFv in nude mice bearing SCLC xenografts.Methods Anti-ProGRP（31-98） scFv was used to detect ProGRP expression by flow cytometry analysis and immunohistochemistry.131I-anti-ProGRP（31-98） scFv was injected intravenously into healthy Kunming mice and the percentage injected dose per gram （%ID/g） in various organs was calculated.Similarly,the %ID/g and tumor/non-tumor ratio in xenograft-bearing mice was calculated.After injection of 131I-anti-ProGRP（31-98） scFv,treated mice were imaged at 1,24,and 30 hours.Then the tumor/base ratios were calculated.Results ProGRP was highly expressed in NCI-H446 cells and xenograft tissue.The metabolism of 131I-anti-ProGRP（31-98） scFv in healthy mice was consistent with a first-order and two-compartment model; T1/2α and T1/2β were 10.2 minutes and 5 hours 18 minutes,respectively.The %ID/g of 131I-anti-ProGRP（31-98） scFv in xenografts was much higher than in healthy tissues at 12 hours after injection,reaching a maximum of （5.38±0.92） %ID/g at 24 hours.Successful imaging of xenograft tissue was achieved as early as 1 hour post-injection and persisted until 30 hours,with 24 hours proving optimal.Conclusion 131I-anti-ProGRP（31-98）scFv shows highly selective tumor uptake with low accumulation in normal tissues and rapid blood clearance,indicating thatit could be a promising agent for SCLC radioimmunoimaging.
