Objective: To study the effect of triple viable capsule combined with antibiotic therapy on the inflammatory factors and intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis. Methods:...Objective: To study the effect of triple viable capsule combined with antibiotic therapy on the inflammatory factors and intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis. Methods: Patients with cirrhosis combined with spontaneous bacterial peritonitis who were treated in Traditional Chinese Medicine Hospital of Shehong County between March 2015 and October 2017 were selected and randomly divided into the observation group who accepted triple viable capsule combined with antibiotic therapy and the control group who accepted conventional symptomatic treatment. The levels of inflammatory factors and intestinal mucosal barrier markers in serum as well as the number of intestinal flora in feces were detected before treatment and 2 weeks after treatment. Results: Compared with those of same group before treatment, PCT, CRP, sTREM-1, MCP-1, TNF-α, IFN-γ, DAO, D-lactic acid, LPS, Occludin and ZO-1 levels in serum as well as the number of enterobacter and enterococcus in feces of both groups of patients were lower whereas the number of bifidobacterium, lactobacillus and clostridium leptum were higher after treatment, and PCT, CRP, sTREM-1, MCP-1, TNF-α, IFN-γ, DAO, D-lactic acid, LPS, Occludin and ZO-1 levels in serum as well as the number of enterobacter and enterococcus in feces of observation group after treatment were lower than those of control group whereas the number of bifidobacterium, lactobacillus and clostridium leptum were higher than those of control group. Conclusion: Triple viable capsule combined with antibiotic therapy can inhibit the secretion of inflammatory cytokines and improve the intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis.展开更多
文摘Objective: To study the effect of triple viable capsule combined with antibiotic therapy on the inflammatory factors and intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis. Methods: Patients with cirrhosis combined with spontaneous bacterial peritonitis who were treated in Traditional Chinese Medicine Hospital of Shehong County between March 2015 and October 2017 were selected and randomly divided into the observation group who accepted triple viable capsule combined with antibiotic therapy and the control group who accepted conventional symptomatic treatment. The levels of inflammatory factors and intestinal mucosal barrier markers in serum as well as the number of intestinal flora in feces were detected before treatment and 2 weeks after treatment. Results: Compared with those of same group before treatment, PCT, CRP, sTREM-1, MCP-1, TNF-α, IFN-γ, DAO, D-lactic acid, LPS, Occludin and ZO-1 levels in serum as well as the number of enterobacter and enterococcus in feces of both groups of patients were lower whereas the number of bifidobacterium, lactobacillus and clostridium leptum were higher after treatment, and PCT, CRP, sTREM-1, MCP-1, TNF-α, IFN-γ, DAO, D-lactic acid, LPS, Occludin and ZO-1 levels in serum as well as the number of enterobacter and enterococcus in feces of observation group after treatment were lower than those of control group whereas the number of bifidobacterium, lactobacillus and clostridium leptum were higher than those of control group. Conclusion: Triple viable capsule combined with antibiotic therapy can inhibit the secretion of inflammatory cytokines and improve the intestinal mucosal barrier function in patients with spontaneous bacterial peritonitis.
