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Clinical analysis of 2790 children with retinoblastoma: a single-center experience in China
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作者 Yi Zhang Yi-Zhuo Wang +14 位作者 Ji-Tong Shi Jian-Min Ma Bin Li Wei-Ling Zhang Hua-Li Gu Yan Zhou Yan-Yan Mei Song Li Ting-Ting Liu Li-Bin Jiang hong-shu zhao Xin Ge Hui-Min Hu Tian Zhi Dong-Sheng Huang 《World Journal of Pediatrics》 SCIE CSCD 2023年第12期1169-1180,共12页
Background In this study,we aimed to analyze the clinical characteristics and prognosis of children with retinoblastoma(RB)in a single center in China with a large sample collection spanning 17 years.Methods The clini... Background In this study,we aimed to analyze the clinical characteristics and prognosis of children with retinoblastoma(RB)in a single center in China with a large sample collection spanning 17 years.Methods The clinical data of 2790 children with RB treated in Beijing Tongren Hospital from 2005 to 2021 were collected,and a retrospective analysis was conducted.Results The median age of the participants was 28.3 months.There were 3624 affected eyes,12.4%of which were in groups A–C,67.1%in groups D–E and 16.2%were not specified.The primary symptom observed in most cases was a white pupil,accounting for 66.5%,followed by strabismus(12.8%).The median follow-up time was 59.7 months.The enucleation rate was 71.3%(703/986)in a single left eye and 72.5%(702/968)in a single right eye.The overall survival(OS)rate was 95.8%(2444/2552)because 237 patients dropped out,and 109 died.Kaplan‒Meier survival analysis showed that the median survival time(MST)was 125.92 months[95%confidence interval(CI)=124.83–127.01].Cox multivariate survival analysis showed that trilateral RB(P=0.017),metastasis site(P=0.001),and combined distant tissue metastasis(P=0.001)were independent prognostic factors for RB.The OS of 44 cases of familial RB was 93.2%(41/44),with an MST of 80.62 months(95%CI=67.70–93.54).Conclusions The timing of eye protection treatment and enucleation should be comprehensively judged to avoid worsening prognosis due to operation time delay.More importantly,the promotion and popularization of diagnosis and treatment technologies are necessary to further improve RB prognosis. 展开更多
关键词 Disease characteristics-Large sample PROGNOSIS RETINOBLASTOMA Retrospective analysis Single center
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