期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Effect of anesthesia on cognitive status and MMP-2 expression in rats
1
作者 hong-tu li Quan-Jun Cao +1 位作者 Xiang-Jie Qi Wei-ling Lu 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第4期333-336,共4页
Objective:To investigate the effect of anesthesia on the cognitive status damage and MMP-2expression in rats.Methods:A total of 120 healthy rats were selected and randomly divided into the control group,CF3-CH(OCH2F)-... Objective:To investigate the effect of anesthesia on the cognitive status damage and MMP-2expression in rats.Methods:A total of 120 healthy rats were selected and randomly divided into the control group,CF3-CH(OCH2F)-CF3(Sevoflurane)group and CF3-CH2-O-CHF-CF3group(Sevoflurane)(n=40).After training for 3 d by the Morris water maze,the control group were injected with fentanyl for analgesia,the CF3-CH(OCH2F)-CF3 group and the CF3-CH2-O-CHFCF3 group were anesthesia with CF3-CH(OCH2F)-CF3 and CF3-CH2-O-CHF-CF3 on the basis of fentanyl,then rats in three groups underwent open surgery and suture conventional incision.Morris water maze was used to measure the rats cognitive ability in three groups on the 1st d,3rd d,5th d and 7th d,and the brain tissue MMP-2 expression was detected.Results:After1 d/7 d of the surgery,Morris water maze performance and MMP-2 expression were not significantly different among three groups(P>0.05);After 3 d/5 d of the surgery,compared with the control group,the Morris water maze test result was significantly worsened,MMP-2expression levels were significantly increased(P<0.05);After 3 d/5 d of the surgery,compared with the CF3-CH2-O-CHF-CF3 group,Morris water maze test result of CF3-CH(OCH2F)-CF3group was significantly worsened,MMP-2 expression levels were significantly increased(P<0.05).Conclusions:Anesthesia can cause some injury on cognitive status,different anesthetic drugs may cause different injury,and the cognitive status injury is related to the MMP-2 expression. 展开更多
关键词 ANESTHESIA COGNITION MATRIX METALLOPROTEINASE-2 Influence study
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部