BACKGROUND Numerous studies have assessed the efficacy and safety of fecal microbiota transplantation(FMT)as a therapy for ulcerative colitis(UC).However,the treatment processes and outcomes of these studies vary.AIM ...BACKGROUND Numerous studies have assessed the efficacy and safety of fecal microbiota transplantation(FMT)as a therapy for ulcerative colitis(UC).However,the treatment processes and outcomes of these studies vary.AIM To evaluate the efficacy and safety of FMT for treating UC by conducting a systematic meta-analysis.METHODS The inclusion criteria involved reports of adult patients with UC treated with FMT,while studies that did not report clinical outcomes or that included patients with infection were excluded.Clinical remission(CR)and endoscopic remission(ER)were the primary and secondary outcomes,respectively.RESULTS We included nine studies retrieved from five electronic databases.The FMT group had better CR than the control group[relative risk(RR)=1.53;95%confidence interval(CI):1.19-1.94;P<0.0008].ER was statistically significantly different between the two groups(RR=2.80;95%CI:1.93-4.05;P<0.00001).Adverse events did not differ significantly between the two groups.CONCLUSION FMT demonstrates favorable performance and safety;however,well-designed randomized clinical trials are still needed before the widespread use of FMT can be recommended.Furthermore,standardizing the FMT process is urgently needed for improved safety and efficacy.展开更多
The properties of aluminosilicate kalsilite have attracted the interest of researchers in chemical synthesis, ceramic industry, biofuels, etc. In this study, kalsilite was hydrothermally synthesized from microcline po...The properties of aluminosilicate kalsilite have attracted the interest of researchers in chemical synthesis, ceramic industry, biofuels, etc. In this study, kalsilite was hydrothermally synthesized from microcline powder in a KOH solution. The microcline powder, rich in potassium, aluminum, and silicon, was collected from Mountain Changling in Northwestem China. The effects of temperature, time, and KOH concentration on the decomposition of microcline were investigated. The kalsilite and intermediate products were characterized by means of wet chemistry analysis, X-ray Diffraction （XRD）, infi＇ared spectrometry （IR）, 29Si magic angle spinning nuclear magnetic resonance （29Si MAS NMR）, 27A1 MAS NMR, and scanning electron microscope （SEM）. With increasing temperature, the microcline powder transforms into a metastable KAlSiO4 polymorph before transforming further into pure kalsilite. A mixture of both kalsilite and metastable KAlSiO4 polymorph is obtained when the hydrothermal reaction is carried out within 2 h; but after 2 h, kalsilite is the predominant product. The concentration of KOH, which needs to be larger than 4.3 M, is an important parameter influencing the synthesis ofkalsilite.展开更多
Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic ...Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses （including 1 D, 2D NMR, and HR-ESI-MS） and chemical methods. Compounds 1-3 were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.展开更多
基金the Tianjin Health Science and Technology Project,No.TJWJ2021MS011.
文摘BACKGROUND Numerous studies have assessed the efficacy and safety of fecal microbiota transplantation(FMT)as a therapy for ulcerative colitis(UC).However,the treatment processes and outcomes of these studies vary.AIM To evaluate the efficacy and safety of FMT for treating UC by conducting a systematic meta-analysis.METHODS The inclusion criteria involved reports of adult patients with UC treated with FMT,while studies that did not report clinical outcomes or that included patients with infection were excluded.Clinical remission(CR)and endoscopic remission(ER)were the primary and secondary outcomes,respectively.RESULTS We included nine studies retrieved from five electronic databases.The FMT group had better CR than the control group[relative risk(RR)=1.53;95%confidence interval(CI):1.19-1.94;P<0.0008].ER was statistically significantly different between the two groups(RR=2.80;95%CI:1.93-4.05;P<0.00001).Adverse events did not differ significantly between the two groups.CONCLUSION FMT demonstrates favorable performance and safety;however,well-designed randomized clinical trials are still needed before the widespread use of FMT can be recommended.Furthermore,standardizing the FMT process is urgently needed for improved safety and efficacy.
基金financially supported by the Key Projects in the National Science & Technology Pillar Program during the Eleventh Five-year Plan Period (No. 2006BAD10B04)
文摘The properties of aluminosilicate kalsilite have attracted the interest of researchers in chemical synthesis, ceramic industry, biofuels, etc. In this study, kalsilite was hydrothermally synthesized from microcline powder in a KOH solution. The microcline powder, rich in potassium, aluminum, and silicon, was collected from Mountain Changling in Northwestem China. The effects of temperature, time, and KOH concentration on the decomposition of microcline were investigated. The kalsilite and intermediate products were characterized by means of wet chemistry analysis, X-ray Diffraction （XRD）, infi＇ared spectrometry （IR）, 29Si magic angle spinning nuclear magnetic resonance （29Si MAS NMR）, 27A1 MAS NMR, and scanning electron microscope （SEM）. With increasing temperature, the microcline powder transforms into a metastable KAlSiO4 polymorph before transforming further into pure kalsilite. A mixture of both kalsilite and metastable KAlSiO4 polymorph is obtained when the hydrothermal reaction is carried out within 2 h; but after 2 h, kalsilite is the predominant product. The concentration of KOH, which needs to be larger than 4.3 M, is an important parameter influencing the synthesis ofkalsilite.
基金financially supported by the National Natural Science Foundation of China (Nos. 81402803, 31171695)the Science and Technology Support Programs of Sichuan Province (No. 2013SZ0083, 2015GZ0233)+2 种基金the Research Foundation for Educational Commission of Sichuan Province (No. 15TD0048)the Fundamental Research Funds for Central Universities (No. 2682014RC15)national undergraduate training programs for innovation and entrepreneurship (No. 201510613065)
文摘Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses （including 1 D, 2D NMR, and HR-ESI-MS） and chemical methods. Compounds 1-3 were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.
