早期食管基底细胞样鳞状细胞癌的内镜特征及预后分析

目的研究早期食管基底细胞样鳞状细胞癌(EBSCC)的内镜特征、治疗效果及预后。方法回顾性分析2014年1月-2020年12月该院发现并行ESD治疗的早期EBSCC患者32例(EBSCC组),纳入同期行内镜黏膜下剥离术(ESD)治疗的普通典型早期食管鳞状细胞癌(ESCC)患者96例作为对照组(ESCC组),对比分析两组患者年龄、性别、肿瘤大小、肿瘤浸润深度、内镜特征、治疗结果及生存率等。结果两组患者发病年龄(P=0.746)、性别(P=0.506)、肿瘤大小(P=0.423)和肿瘤浸润深度(P=0.914)比较,差异均无统计学意义。两组患者肿瘤均好发于食管中段,内镜下分型以0-Ⅱb型为主,所有病灶表面黏膜均粗糙和/或糜烂,放大内镜观察上皮内乳头状毛细血管袢(IPCL),以B1型为主,两组患者比较,差异无统计学意义(P>0.05)。EBSCC组较ESCC组病灶表面白斑出现的概率更高,差异有统计学意义(56.25%和26.04%,χ^(2)=9.88,P=0.002)。碘液染色:EBSCC组有17例(53.12%)为不染或淡染,15例(46.88%)有斑驳状不染改变(即碘不染区域中可见岛状染色斑点或者深染斑点);ESCC组有72例(75.00%)为不染或淡染,24例(25.00%)有斑驳状不染改变,两组患者碘液染色后改变比较,差异有统计学意义(χ^(2)=5.42,P=0.020)。两组患者治疗后生存率比较,差异无统计学意义(93.75%和96.88%,χ^(2)=0.62,P=0.429)。结论早期EBSCC内镜下表现不一致,病灶表面白斑、碘液染色后呈斑驳状不染改变和放大内镜结合窄带成像技术观察到B型血管,提示可能存在基底细胞样鳞状细胞癌(BSCC)成分。早期治疗EBSCC可提高患者生存率,改善预后。

KTP激光联合环形硅胶管植入治疗泪道阻塞的安全性及疗效分析

目的探究使用KTP激光联合环形硅胶植入手术治疗泪道阻塞的疗效以及术后并发生症情况。方法选取2012年3月-2015年3月河北省眼科医院142例泪道阻塞患者作为研究对象,根据的不同的治疗方法随即分为两组,并分别进行KTP激光联合环形硅胶管植入手术治疗以及单纯KTP激光治疗,比较两组的疗效以及术后的并发症、复发率情况。结果观察组以及对照组的手术后6个月的总有效率分别为92.13%和81.18%,差异有统计学意义(P<0.05),观察组低于对照组;观察组患者的满意度评分与对照组比较,差异有统计学意义(P<0.05),观察组高于对照组;观察组的并发症发生率和复发率与对照组比较,差异有统计学意义(P<0.05),观察组均低于对照组。结论使用KTP激光联合环形硅胶管治疗泪道阻塞在提高疗效,减少并发症以及复发率方面有明显的优势,值得在临床中广泛使用。

Flash flood hazard mapping: A pilot case study in Xiapu River Basin, China

Flash flood hazard mapping is a supporting component of non-structural measures for flash flood prevention. Pilot case studies are necessary to develop more practicable methods for the technical support systems of flash flood hazard mapping. In this study, the headwater catchment of the Xiapu River Basin in central China was selected as a pilot study area for flash flood hazard mapping. A conceptual distributed hydrological model was developed for flood calculation based on the framework of the Xinanjiang model, which is widely used in humid and semi-humid regions in China. The developed model employs the geomorphological unit hydrograph method, which is extremely valuable when simulating the overland flow process in ungauged catchments, as compared with the original Xinanjiang model. The model was tested in the pilot study area, and the results agree with the measured data on the whole. After calibration and validation, the model is shown to be a useful tool for flash flood calculation. A practicable method for flash flood hazard mapping using the calculated peak discharge and digital elevation model data was presented, and three levels of flood hazards were classified. The resulting flash flood hazard maps indicate that the method successfully predicts the spatial distribution of flash flood hazards, and it can meet the current requirements in China.

Toward Development of a Whole-genome, BAC/BIBAC-based Integrated Physical/Genetic Map of the Cotton Genome Using the Upland Genetic Standard TM-1: BAG and BIBAC Library Construction, SSR Marker Development, and Physical/Genetic Map Integration

Integrative physical mapping is the centerpieceof and essential for advanced genomics research.Upland cotton(Gossypium hirsutum L.)geneticstandard line TM-1 is used as the referencegenotype to develop a whole-genome,BAC/BIBAC-based integrated physical/genetic map ofthe cotton genome.From the TM-1 line we haveconstructed two BAC libraries with HindIII

Factors associated with patient absenteeism for scheduled endoscopy

AIM: To identify risk factors to help predict which patients are likely to fail to appear for an endoscopic procedure. METHODS: This was a retrospective, chart review, cohort study in a Canadian, tertiary care, academic, hospital-based endoscopy clinic. Patients included were: those undergoing esophagogastroduodenoscopy, colonoscopy or flexible sigmoidoscopy and patients who failed to appear were compared to a control group. The main outcome measure was a multivariate analysis of factors associated with truancy from scheduled endoscopic procedures. Factors analyzed included gender, age, waiting time, type of procedure, referring physician, distance to hospital, first or subsequent endoscopic procedure or encounter with gastroenterologist, and urgency of the procedure. RESULTS: Two hundred and thirty-four patients did not show up for their scheduled appointment. Compared to a control group, factors statistically significantly associated with truancy in the multivariate analysis were: non-urgent vs urgent procedure (OR 1.62, 95% CI 1.06, 2.450), referred by a specialist vs a family doctor (OR 2.76, 95% CI 1.31, 5.52) and office-based consult prior to endoscopy vs consult and endoscopic procedure during the same appointment (OR 2.24, 95% CI 1.33, 3.78). CONCLUSION: Identifying patients who are not scheduled for same-day consult and endoscopy, those referred by a specialist, and those with non-urgent referrals may help reduce patient truancy.

Effective treatment of polyneuropathy,organomegaly,endocrinopathy,M-protein,and skin changes syndrome with congestive heart failure:A case report

BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,and skin changes(POEMS)syndrome is a rare paraneoplastic syndrome caused by a plasma cell proliferative disorder.The syndrome is characterized by elevated plasma cells,platelets,and vascular endothelial growth factor levels.Although heart disease rarely occurs in POEMS syndrome,the death rate increases sharply after heart failure.We report a patient who initially presented with an endocrine disease and developed congestive heart failure related to POEMS syndrome 9 years later.CASE SUMMARY A 23-year-old woman with no history of menstruation and a 9-year history of type I diabetes reported feeling breathless after activities.She could not lie down and rest at night.Three months prior,she experienced pain and increased tension in her left thigh accompanied by tenderness and edema in both lower extremities.The chief complaint upon hospital admission was that blood sugar has increased for more than 9 years,pain in the left thigh,and edema in both legs for more than 2 mo.After a multisystem evaluation,she was diagnosed with POEMS syndrome.Her echocardiogram showed left ventricular dilation with systolic dysfunction,and the left ventricular ejection fraction was only 38%with severely elevated brain natriuretic peptide.She received a combination of dexamethasone and thalidomide for 1 mo,but her symptoms did not improve.Therefore,we added a two-per-week bortezomib injection.After 2 wk,the patient’s heart function had improved significantly.CONCLUSION This case provides information about the treatment of POEMS syndrome with complications and highlights the challenges of developing a standardized treatment.

Oxidative dearomatic approach towards the synthesis of erythrina skeleton:a formal synthesis of demethoxyerythratidinone

A concise synthetic route leading to highly functional erythrina alkaloid skeletons has been developed.The key process is an oxidative carbon-carbon coupling followed by a conjugated addition.Based on this new strategy,a formal synthesis of demethoxyerythratidinone was completed in only 6 steps from 4-aminophenol.

Sesquiterpenoids and an ergosterol from cultures of the fungus Daedaleopsis tricolor

Four new bisabolane sesquiterpenoids daedatrins A-D(1-4),a cadinane sesquiterpene 12-hydroxy-α-cadinol(5),and a heptanorergosterane derivative daedatrin G(6)were isolated from cultures of the basidiomycete Daedaleopsis tricolor.Their structures were elucidated by spectroscopic methods including extensive 2D NMR techniques and X-ray crystallography.All the compounds showed no significant activity against five human cancer cell lines.

Stability Analysis of Uncertain Discrete-Time Piecewise Linear Systems with Time Delays

This paper considers the stability analysis of uncertain discrete-time piecewise linear systems with time delays based on piecewise Lyapunov-Krasovskii functionals. It is shown that the stability can be established for the control systems if there is a piecewise Lyapunov-Krasovskii functional, and moreover, the functional can be obtained by solving a set of linear matrix inequalities （LMIs） that are numerically feasible. A numerical example is given to demonstrate the efficiency and advantage of the proposed method.

利用BAC、BIBAC文库整合构建陆地棉遗传标准系TM 1全基因组的遗传、物理图谱：BAC文库的指纹分析及重叠群构建

We are developing a whole-genome, BAC/BIBAC-based integrated physical/genetic map of the cotton (Gossypium hirsutum L. ) genome using its genetic standard line TM-1 as the reference genotype. Whole-genome physical maps integrated with genetic maps will provide revolutionized tools and platforms for all kinds of genomics research, including large-scale gene mapping, cloning and target DNA marker development.……

Toward Development of a Whole-genome,BAC/BIBAC-based IntegratedPhysical/Genetic Map of the Cotton Genome Using the Upland Cotton Genetic Standard TM-1:BAC Fingerprinting and Physical Map Contig Construction

We are developing a whole-genome,BAC/BIBAC-based integrated physical/genetic map ofthe cotton(Gossypium hirsutum L.)genomeusing its genetic standard line TM-1 as thereference genotype.Whole-genome physicalmaps integrated with genetic maps will providerevolutionized tools and platforms for all kindsof genomics researeh,including large-scale gene mapping,cloning and target DNA marker development.

Insight into vertical piezoelectric characteristics regulated thermal transport in van der Waals two-dimensional materials

The urgent demand of extreme(ultra-high/low)thermal conductivity materials is triggered by the high-power device,where exploring the theories and mechanisms of regulating thermal transport properties plays a key role.Herein,we elaborately investigate the effect of vertical(out-of-plane)piezoelectric characteristics on thermal transport,which is historically undiscovered.The different stacking-order(AA and AB)bilayer boron nitride(Bi-BN)in two-dimensional(2D)materials are selected as study cases.By performing state-of-the-art first-principles calculations,it is found that the polarization charge along the out-of-plane orientation ascends significantly with the increasing piezoelectric response in AB stacked Bi-BN(Bi-BN-AB)followed by the enhanced interlayer B–N atomic interactions.Consequently,the amplitude of phonon anharmonicity in Bi-BN-AB increases larger than that in the AA stacked Bi-BN(Bi-BN-AA),resulting in the dramatic weakening of the thermal conductivity by 20.34%under 18%strain.Our research reveals the significant role of the vertical(out-of-plane)piezoelectric characteristic in regulating thermal transport and provides new insight into accurately exploring the thermal transport performance of 2D van der Waals materials.

Realizing ultra-low thermal conductivity by strong synergy of asymmetric geometry and electronic structure in boron nitride and arsenide

The design of novel devices with specific technical interests through modulating structural properties and bonding characteristics promotes the vigorous development of materials informatics.Boron arsenide and boron nitride,as remarkably high thermal conductivity(κ)materials,are unfavorable for thermal insulation applications as well as thermoelectric devices.In this study,based on first-principles calculations,we identify a group of novel borides with ultra-lowκ,i.e.,g-B_(3)X_(5)(X=N,P,and As).Theκof g-B_(3)N_(5),g-B_(3)P_(5),and g-B_(3)As_(5)are 21.08,2.50,and 1.85 W·m^(-1)·K^(-1),respectively,which are boron nitride and boron arsenide systems with the lowestκreported so far.The ultra-lowκis attributed to the synergy effect of electronics(lone-pair electrons)and geometry(buckling structures)on thermal transport.The discovery of the ultralowκof boron nitride and boron arsenide systems can well fill the gaps in applications of thermal insulation and thermoelectric devices.

Microstructure and Mechanical Behavior of CrFeNi2V0.5Wx(x=0,0.25)High-Entropy Alloys

CrFeNi2V0.5Wx(x=0,0.25)alloys based on these parameters of mixing enthalpy(△Hmix,mixing entropy(△Smix,atomic radius difference(δ),valance electron concentration,and electronegativity difference(△χ)were designed and prepared.The microstructure and room-temperature mechanical behavior of both alloys were investigated.Compressive test results showed that the CrFeNi2V0.5W0.25 alloy had higher yield strength than that of the W-free CrFeNi2V0.5 alloy,although they all exhibited quite larger compressive plasticity(ε>70%).Compression fracture surface of CrFeNi2V0.5W0.25 alloy revealed a ductile fracture in the face-centered cubic(FCC)phase and a brittle-like fracture in theσphase.Moreover,tensile test results indicated that the CrFeNi2V0.5W0.25 alloy exhibited excellent mechanical property with an ultimate tensile strength of 640 MPa and a high tensile elongation of 15.7%.The tensile deformation mode of the FCC phase in the CrFeNi2V0.5W0.25alloy is dominated by planar glide,relating to dislocation configurations,high-density dislocations,and dislocation wall.Therefore,dislocation slip plays a significant role in tensile deformation of CrFeNi2V0.5W0.25 high-entropy alloy.The higher strength of CrFeNi2V0.5W0.25 alloy is predominantly due to the solid solution strengthening of W element andσphase precipitation strengthening.Combination of the higher tensile strength and plasticity suggests that the CrFeNi2V0.5W0.25 alloy can be a promising aerospace material.

Strong hopping induced Dzyaloshinskii–Moriya interaction and skyrmions in elemental cobalt

The Dzyaloshinskii–Moriya interaction(DMI)is well known to favor a chiral rotation of the magnetic moments,which accounts for the emergence of the skyrmions.The DMI is a combined effect of spin–orbit coupling with broken inversion symmetry in magnets.Most of the noncentrosymmetric magnetic materials that bear skyrmions involve nonmagnetic elements.This work shows that strong DMIs exist in elemental cobalt with a β-Mn-type metastable structure.The variation of DMI among different cobalt pairs largely follows the variation of hopping magnitude in which p electrons play an important role.Although the DMIs between different atomic pairs partly cancels with each other,the net interaction is sufficient to result in a left-handed Bloch-type spiral.Spin dynamics simulation shows that a critical magnetic field of 2.9 T stabilizes skyrmions at 0 K.