Clinical outcomes are positively associated with hematoma absorption.The monocyte-macrophage scavenger receptor,CD163,plays an important role in the metabolism of hemoglobin,and a soluble form of CD163 is present in p...Clinical outcomes are positively associated with hematoma absorption.The monocyte-macrophage scavenger receptor,CD163,plays an important role in the metabolism of hemoglobin,and a soluble form of CD163 is present in plasma and other tissue fluids;therefore,we speculated that serum CD163 affects hematoma absorption after intracerebral hemorrhage.Patients with intracerebral hemorrhage were divided into high-and low-level groups according to the average CD163 level（1,977.79 ± 832.91 ng/m L）.Compared with the high-level group,the low-level group had a significantly slower hematoma absorption rate,and significantly increased National Institutes of Health Stroke Scale scores and modified Rankin Scale scores.These results suggest that CD163 promotes hematoma absorption and the recovery of neurological function in patients with intracerebral hemorrhage.展开更多
BACKGROUND Cerebrotendinous xanthomatosis(CTX)is a rare autosomal recessive metabolic disease caused by mutations in CYP27 A1.It has a low incidence rate,insidious onset,and diverse clinical manifestations.It can be e...BACKGROUND Cerebrotendinous xanthomatosis(CTX)is a rare autosomal recessive metabolic disease caused by mutations in CYP27 A1.It has a low incidence rate,insidious onset,and diverse clinical manifestations.It can be easily misdiagnosed and can go unrecognized by clinicians,leading to delayed treatment and worsened patient outcomes.CASE SUMMARY A 38-year-old male was admitted to our hospital with a history of unabating unstable posture and difficulty in walking for more than 30 years.Subsequently based on the patient’s medical history,clinical symptoms,magnetic resonance imaging and gene sequencing results,he was finally diagnosed with CTX.Due to the low incidence rate of the disease,clinicians have insufficient knowledge of it,which makes the diagnosis process more tortuous and prolongs the diagnosis time.CONCLUSION Prompt diagnosis and treatment of CTX improve patient outcomes.展开更多
BACKGROUND Sj?gren syndrome(SS)is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands.And histoplasmosis is an invasive mycosis caused by the saprophytic dimorphi...BACKGROUND Sj?gren syndrome(SS)is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands.And histoplasmosis is an invasive mycosis caused by the saprophytic dimorphic fungus H.capsulatum.In patients with primary SS(PSS),disseminated histoplasmosis(DH)is extremely rare.CASE SUMMARY We report a 37-year-old female patient admitted to our hospital with exacerbating fatigue,somnolence,and pancytopenia as the main symptoms.She was eventually diagnosed with DH based on pancytopenia,splenomegaly,and findings of bone marrow smears.The atypical clinical symptoms made the diagnosis process more tortuous.Unfortunately,she died of respiratory failure on the day the diagnosis was confirmed.CONCLUSION We present a rare and interesting case of DH in a PSS patient.This case updates the geographic distribution of histoplasmosis in China,and expands the clinical manifestations of DH in PSS,highlighting the significance of constantly improving the understanding of PSS with DH.展开更多
文摘Clinical outcomes are positively associated with hematoma absorption.The monocyte-macrophage scavenger receptor,CD163,plays an important role in the metabolism of hemoglobin,and a soluble form of CD163 is present in plasma and other tissue fluids;therefore,we speculated that serum CD163 affects hematoma absorption after intracerebral hemorrhage.Patients with intracerebral hemorrhage were divided into high-and low-level groups according to the average CD163 level（1,977.79 ± 832.91 ng/m L）.Compared with the high-level group,the low-level group had a significantly slower hematoma absorption rate,and significantly increased National Institutes of Health Stroke Scale scores and modified Rankin Scale scores.These results suggest that CD163 promotes hematoma absorption and the recovery of neurological function in patients with intracerebral hemorrhage.
文摘BACKGROUND Cerebrotendinous xanthomatosis(CTX)is a rare autosomal recessive metabolic disease caused by mutations in CYP27 A1.It has a low incidence rate,insidious onset,and diverse clinical manifestations.It can be easily misdiagnosed and can go unrecognized by clinicians,leading to delayed treatment and worsened patient outcomes.CASE SUMMARY A 38-year-old male was admitted to our hospital with a history of unabating unstable posture and difficulty in walking for more than 30 years.Subsequently based on the patient’s medical history,clinical symptoms,magnetic resonance imaging and gene sequencing results,he was finally diagnosed with CTX.Due to the low incidence rate of the disease,clinicians have insufficient knowledge of it,which makes the diagnosis process more tortuous and prolongs the diagnosis time.CONCLUSION Prompt diagnosis and treatment of CTX improve patient outcomes.
基金National Key R&D Program of China,No.2017YFC0110304.
文摘BACKGROUND Sj?gren syndrome(SS)is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands.And histoplasmosis is an invasive mycosis caused by the saprophytic dimorphic fungus H.capsulatum.In patients with primary SS(PSS),disseminated histoplasmosis(DH)is extremely rare.CASE SUMMARY We report a 37-year-old female patient admitted to our hospital with exacerbating fatigue,somnolence,and pancytopenia as the main symptoms.She was eventually diagnosed with DH based on pancytopenia,splenomegaly,and findings of bone marrow smears.The atypical clinical symptoms made the diagnosis process more tortuous.Unfortunately,she died of respiratory failure on the day the diagnosis was confirmed.CONCLUSION We present a rare and interesting case of DH in a PSS patient.This case updates the geographic distribution of histoplasmosis in China,and expands the clinical manifestations of DH in PSS,highlighting the significance of constantly improving the understanding of PSS with DH.
