Objective To investigate the Churg-Strauss syndrome (CSS) associated lung involvement, concentrating on clinical characteristics, pathological findings of tung involvements, response to treatment, and prognosis. Me...Objective To investigate the Churg-Strauss syndrome (CSS) associated lung involvement, concentrating on clinical characteristics, pathological findings of tung involvements, response to treatment, and prognosis. Methods We retrospectively analyzed the characters of the clinical manifestations, thin-section CT and pathological findings of CSS. The study involved 16 patients. Clinical data were obtained by chart review All patients underwent transbronchial lung biopsy (TBLB). Six of them underwent surgical lung biopsy as well. Results The patients included 7 men and 9 women, aged from 14 to 61 years (median, 47.5 years). Extrathoracic organs involved included nervous system (7/16) and skin (5/16). Respiratory symptoms included cough (12/16), exertional dyspnea (11/16), hemoptysis (4/16), and chest pain (3/16). CT findings included bilateral ground-glass opacities (12 / 16), bilateral patchy opacities (12 / 16), and centrilobular nodules (6/16). The pathological findings of TBLB demonstrated increased eosinophils (3/16), vasculitis (3/16), and interstitial pneumonia (16/16). The pathological fmdings of surgical lung biopsy of 6 cases showed necrotizing vasculitis in 4 cases, capillaries in 5, eosinophilic pneumonia in 3, granulomas in 2, and airway abnormalities in 3. All patients improved in symptoms after therapy during the study period (range, 3 to 51 months; median, 15 months). Conclusions Asthma may be present in CSS patient when there is bronchial involvement. Grotmd-glass opacities and consolidation seen on high-resolution CT reflect the presence of eosinophilic pneumonia, vasculitis, and pulmonary alveolar hemorrhage. TBLB has significant limitations for the diagnosis of CSS. Early diagnosis and therapy can result in satisfactory prognosis.展开更多
For photon detection, superconducting transition-edge sensor(TES) micro-calorimeters are excellent energy-resolving devices. In this study, we report our recent work in developing Ti-/Au-based TES. The Ti/Au TES devic...For photon detection, superconducting transition-edge sensor(TES) micro-calorimeters are excellent energy-resolving devices. In this study, we report our recent work in developing Ti-/Au-based TES. The Ti/Au TES devices were designed and implemented with a thickness ratio of 1:1 and different suspended structures using micromachining technology. The characteristics were evaluated and analyzed, including surface morphology, 3 D deformation of suspended Ti/Au TES device structure, I–V characteristics, and low-temperature superconductivity. The results showed that the surface of Ti/Au has good homogeneity and the surface roughness of Ti/Au is significantly increased compared with the substrate. The structure of Ti/Au bilayer film significantly affects the deformation of suspended devices, but the deformation does not affect the I–V characteristics of the devices. For devices with the Ti/Au bilayer(150 μm × 150 μm) and beams(100 μm × 25 μm), the transition temperature(T;) is 253 m K with a width of 6 m K, and the value of the temperature sensitivity α is 95.1.展开更多
Background:Actinomycosis is a rare indolent infectious disease caused by Actinomyces.Although pulmonary actinomycosis is thought to be more prevalent in developing countries,data from developing countries are scanty....Background:Actinomycosis is a rare indolent infectious disease caused by Actinomyces.Although pulmonary actinomycosis is thought to be more prevalent in developing countries,data from developing countries are scanty.This study was to reveal the current situation of pulmonary actinomycosis in developing countries and the difference from that in developed countries.Methods:Patients fulfilling the inclusion criteria for pulmonary actinomycosis from Peking Union Medical College Hospital in China between January 2003 and December 2014 were retrospectively analyzed.Baseline characteristics,clinical symptoms,underlying diseases,diagnostic methods,pulmonary function test results,chest computed tomography (CT) tests,fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) tests,initial diagnosis,treatment and prognosis were retrieved from medical records and analyzed.Results:Twenty-six patients were included in this study (mean age 52.0 + 13.1 years).The ratio of male to female was 1.17:1.Most common clinical symptoms were cough (15/26),sputum (12/26) and hemoptysis (12/26).Chest CT findings presented as masses (13/26),nodules (10/26) and infiltrates (3/26).FDG-PET had an increased standardized uptake value and 4/6 patients were misdiagnosed as malignancy.Many kinds of antibiotics were used in the treatment of pulmonary actonomycosis and all got favorable results.Five patients receiving complete resection of the lesion were cured without postoperative use of antibiotic.Conclusions:Pulmonary actinomycosis is a rare disease even in developing countries,and both misdiagnosis and missed diagnosis are common.FDG-PET seems useless in the differential diagnosis,and complete resection of the pulmonary lesion without postoperative antibiotic therapy might be enough to achieve cure.展开更多
The film industry is currently witnessing a severe shortage of good stories and a decline in storytelling art.Meanwhile,creative computing has been employed successfully in the humanities,especially in the fields of a...The film industry is currently witnessing a severe shortage of good stories and a decline in storytelling art.Meanwhile,creative computing has been employed successfully in the humanities,especially in the fields of art.Seeing the similarities between the process of film-story creation and that of creative computing,we propose a theoretical framework across the two domains,where the exploratory,the combinational and the transformational rules are jointly utilized to generate new ideas and provide potential options in film-story creation.The framework consists of a film knowledge library,a creative computing system,an evaluation model and an output module.The combination of creative computing and film story creation not only helps to produce novel storylines,shorten the creation cycle,and speed up film industry,but also contributes to the novelty and specificity of interdisciplinary studies.展开更多
文摘Objective To investigate the Churg-Strauss syndrome (CSS) associated lung involvement, concentrating on clinical characteristics, pathological findings of tung involvements, response to treatment, and prognosis. Methods We retrospectively analyzed the characters of the clinical manifestations, thin-section CT and pathological findings of CSS. The study involved 16 patients. Clinical data were obtained by chart review All patients underwent transbronchial lung biopsy (TBLB). Six of them underwent surgical lung biopsy as well. Results The patients included 7 men and 9 women, aged from 14 to 61 years (median, 47.5 years). Extrathoracic organs involved included nervous system (7/16) and skin (5/16). Respiratory symptoms included cough (12/16), exertional dyspnea (11/16), hemoptysis (4/16), and chest pain (3/16). CT findings included bilateral ground-glass opacities (12 / 16), bilateral patchy opacities (12 / 16), and centrilobular nodules (6/16). The pathological findings of TBLB demonstrated increased eosinophils (3/16), vasculitis (3/16), and interstitial pneumonia (16/16). The pathological fmdings of surgical lung biopsy of 6 cases showed necrotizing vasculitis in 4 cases, capillaries in 5, eosinophilic pneumonia in 3, granulomas in 2, and airway abnormalities in 3. All patients improved in symptoms after therapy during the study period (range, 3 to 51 months; median, 15 months). Conclusions Asthma may be present in CSS patient when there is bronchial involvement. Grotmd-glass opacities and consolidation seen on high-resolution CT reflect the presence of eosinophilic pneumonia, vasculitis, and pulmonary alveolar hemorrhage. TBLB has significant limitations for the diagnosis of CSS. Early diagnosis and therapy can result in satisfactory prognosis.
文摘For photon detection, superconducting transition-edge sensor(TES) micro-calorimeters are excellent energy-resolving devices. In this study, we report our recent work in developing Ti-/Au-based TES. The Ti/Au TES devices were designed and implemented with a thickness ratio of 1:1 and different suspended structures using micromachining technology. The characteristics were evaluated and analyzed, including surface morphology, 3 D deformation of suspended Ti/Au TES device structure, I–V characteristics, and low-temperature superconductivity. The results showed that the surface of Ti/Au has good homogeneity and the surface roughness of Ti/Au is significantly increased compared with the substrate. The structure of Ti/Au bilayer film significantly affects the deformation of suspended devices, but the deformation does not affect the I–V characteristics of the devices. For devices with the Ti/Au bilayer(150 μm × 150 μm) and beams(100 μm × 25 μm), the transition temperature(T;) is 253 m K with a width of 6 m K, and the value of the temperature sensitivity α is 95.1.
文摘Background:Actinomycosis is a rare indolent infectious disease caused by Actinomyces.Although pulmonary actinomycosis is thought to be more prevalent in developing countries,data from developing countries are scanty.This study was to reveal the current situation of pulmonary actinomycosis in developing countries and the difference from that in developed countries.Methods:Patients fulfilling the inclusion criteria for pulmonary actinomycosis from Peking Union Medical College Hospital in China between January 2003 and December 2014 were retrospectively analyzed.Baseline characteristics,clinical symptoms,underlying diseases,diagnostic methods,pulmonary function test results,chest computed tomography (CT) tests,fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) tests,initial diagnosis,treatment and prognosis were retrieved from medical records and analyzed.Results:Twenty-six patients were included in this study (mean age 52.0 + 13.1 years).The ratio of male to female was 1.17:1.Most common clinical symptoms were cough (15/26),sputum (12/26) and hemoptysis (12/26).Chest CT findings presented as masses (13/26),nodules (10/26) and infiltrates (3/26).FDG-PET had an increased standardized uptake value and 4/6 patients were misdiagnosed as malignancy.Many kinds of antibiotics were used in the treatment of pulmonary actonomycosis and all got favorable results.Five patients receiving complete resection of the lesion were cured without postoperative use of antibiotic.Conclusions:Pulmonary actinomycosis is a rare disease even in developing countries,and both misdiagnosis and missed diagnosis are common.FDG-PET seems useless in the differential diagnosis,and complete resection of the pulmonary lesion without postoperative antibiotic therapy might be enough to achieve cure.
基金The work is sponsored in part by National Natural Science Foundation of China(No.61877044).
文摘The film industry is currently witnessing a severe shortage of good stories and a decline in storytelling art.Meanwhile,creative computing has been employed successfully in the humanities,especially in the fields of art.Seeing the similarities between the process of film-story creation and that of creative computing,we propose a theoretical framework across the two domains,where the exploratory,the combinational and the transformational rules are jointly utilized to generate new ideas and provide potential options in film-story creation.The framework consists of a film knowledge library,a creative computing system,an evaluation model and an output module.The combination of creative computing and film story creation not only helps to produce novel storylines,shorten the creation cycle,and speed up film industry,but also contributes to the novelty and specificity of interdisciplinary studies.