Objective:This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder(PTSD).Methods:The Web of Science database(2007-2022)was searched using the search terms“phytochemical...Objective:This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder(PTSD).Methods:The Web of Science database(2007-2022)was searched using the search terms“phytochemicals”and“PTSD,”and relevant literature was compiled.Network clustering co-occurrence analysis and qualitative narrative review were conducted.Results:Three hundred and one articles were included in the analysis of published research,which has surged since 2015 with nearly half of all relevant articles coming from North America.The category is dominated by neuroscience and neurology,with two journals,Addictive Behaviors and Drug and Alcohol Dependence,publishing the greatest number of papers on these topics.Most studies focused on psychedelic intervention for PTSD.Three timelines show an“ebb and flow”phenomenon between“substance use/marijuana abuse”and“psychedelic medicine/medicinal cannabis.”Other phytochemicals account for a small proportion of the research and focus on topics like neurosteroid turnover,serotonin levels,and brain-derived neurotrophic factor expression.Conclusion:Research on phytochemicals and PTSD is unevenly distributed across countries/regions,disciplines,and journals.Since 2015,the research paradigm shifted to constitute the mainstream of psychedelic research thus far,leading to the exploration of botanical active ingredients and molecular mechanisms.Other studies focus on anti-oxidative stress and anti-inflammation.展开更多
Objective:To study the correlation of the quantitative ultrasonography parameters with liver cancer cell proliferation activity and intralesional angiogenesis.Methods: A total of 46 patients with liver cancer who rece...Objective:To study the correlation of the quantitative ultrasonography parameters with liver cancer cell proliferation activity and intralesional angiogenesis.Methods: A total of 46 patients with liver cancer who received surgical resection in Hancheng People's Hospital between June 2014 and March 2017 as well as 28 patients who received partial hepatectomy for abdominal trauma during the same period were selected, the patients with liver cancer received ultrasonography, and the quantitative parameters were calculated;the liver cancer tissue and adjacent tissue of patients with liver cancer as well as the normal liver tissue of patients with abdominal trauma were collected to determine the expression of proliferation genes, tumor suppressor genes and angiogenesis genes.Results:The IMAX of liver cancer tissue was significantly higher than that of adjacent tissue while the TTP, WT and mTT were significantly shorter than those of adjacent tissue;RNF180, Merlin, PICK1 and PTEN protein expression in liver cancer tissue and adjacent tissue were significantly lower than those in normal liver tissue, negatively correlated with the IMAX of liver cancer tissue, and positively correlated with the TTP, WT and mTT of liver cancer tissue;EphB4, SALL4, Cripto-1, VEGF, PDGF, EGFR and Ang-2 protein expression in liver cancer tissue and adjacent tissue were significantly higher than those in normal liver tissue, positively correlated with the IMAX of liver cancer tissue, and negatively correlated with the TTP, WT and mTT of liver cancer tissue. Conclusion: The changes in the quantitative parameters of liver cancer ultrasonography are valuable for evaluating the cell proliferation and angiogenesis.展开更多
基金the National Natural Science Foundation of China(No.81573150)Military Key Discipline Construction Projects of China(No.HL21JD1206).
文摘Objective:This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder(PTSD).Methods:The Web of Science database(2007-2022)was searched using the search terms“phytochemicals”and“PTSD,”and relevant literature was compiled.Network clustering co-occurrence analysis and qualitative narrative review were conducted.Results:Three hundred and one articles were included in the analysis of published research,which has surged since 2015 with nearly half of all relevant articles coming from North America.The category is dominated by neuroscience and neurology,with two journals,Addictive Behaviors and Drug and Alcohol Dependence,publishing the greatest number of papers on these topics.Most studies focused on psychedelic intervention for PTSD.Three timelines show an“ebb and flow”phenomenon between“substance use/marijuana abuse”and“psychedelic medicine/medicinal cannabis.”Other phytochemicals account for a small proportion of the research and focus on topics like neurosteroid turnover,serotonin levels,and brain-derived neurotrophic factor expression.Conclusion:Research on phytochemicals and PTSD is unevenly distributed across countries/regions,disciplines,and journals.Since 2015,the research paradigm shifted to constitute the mainstream of psychedelic research thus far,leading to the exploration of botanical active ingredients and molecular mechanisms.Other studies focus on anti-oxidative stress and anti-inflammation.
文摘Objective:To study the correlation of the quantitative ultrasonography parameters with liver cancer cell proliferation activity and intralesional angiogenesis.Methods: A total of 46 patients with liver cancer who received surgical resection in Hancheng People's Hospital between June 2014 and March 2017 as well as 28 patients who received partial hepatectomy for abdominal trauma during the same period were selected, the patients with liver cancer received ultrasonography, and the quantitative parameters were calculated;the liver cancer tissue and adjacent tissue of patients with liver cancer as well as the normal liver tissue of patients with abdominal trauma were collected to determine the expression of proliferation genes, tumor suppressor genes and angiogenesis genes.Results:The IMAX of liver cancer tissue was significantly higher than that of adjacent tissue while the TTP, WT and mTT were significantly shorter than those of adjacent tissue;RNF180, Merlin, PICK1 and PTEN protein expression in liver cancer tissue and adjacent tissue were significantly lower than those in normal liver tissue, negatively correlated with the IMAX of liver cancer tissue, and positively correlated with the TTP, WT and mTT of liver cancer tissue;EphB4, SALL4, Cripto-1, VEGF, PDGF, EGFR and Ang-2 protein expression in liver cancer tissue and adjacent tissue were significantly higher than those in normal liver tissue, positively correlated with the IMAX of liver cancer tissue, and negatively correlated with the TTP, WT and mTT of liver cancer tissue. Conclusion: The changes in the quantitative parameters of liver cancer ultrasonography are valuable for evaluating the cell proliferation and angiogenesis.