The Mass Assembly History for Galaxies with MaNGA

How galaxies assemble masses through their own star formation or interaction with the external environment is still an important topic in the field of galaxy formation and evolution.We use Value Added Catalogs with galaxy features that are spatially and temporally resolved from Sloan Digital Sky Survey Data Release 17 to investigate the mass growth histories of early-type galaxies(ETGs)and late-type galaxies(LTGs).We find that the mass growth of ETGs is earlier than that of LTGs for massive galaxies(M_(*)>10^(10)M_⊙),while low-mass(M_(*)≤10^(10)M_⊙)ETGs have statistically similar mass assembly histories as low-mass LTGs.The stellar metallicity of all massive galaxies shows a negative gradient and basically does not change with time.However,in low-mass galaxies,the stellar metallicity gradient of elliptical galaxies is negative,and the stellar metallicity gradient of lenticular and spiral galaxies evolves from positive to negative.ETGs are not all in a high-density environment,but exhibit mass dependence.As the tidal strength increases,the star formation rate of low-mass ETGs rapidly decreases.These results support a picture where massive galaxies exhibit inside-out quenching mode,while low-mass galaxies show outside-in quenching mode.Environmental effects play an important role in regulating the mass assembly histories of low-mass ETGs.

肩关节镜下肩袖修复术后Ⅰ型复杂区域疼痛综合征的危险因素分析

目的探讨肩关节镜下肩袖修复术后发生Ⅰ型复杂区域疼痛综合征的危险因素。方法选取2018年1月—2020年10月在湖南省人民医院骨科因肩袖损伤行肩关节镜下肩袖修复术的346例患者,术后发生Ⅰ型复杂区域疼痛综合征的32例患者为观察组,未发生的314例患者为对照组。比较两组患者的性别构成、年龄、优势侧、冠心病、高血压、糖尿病、颈椎病、高血脂、损伤原因、美国加州大学(UCLA)肩关节评分、视觉模拟评分法(VAS)、Goutallier肩袖肌肉脂肪浸润分型、关节各方向主动活动度和被动活动度、手术时间、住院时间、麻醉方式、撕裂肌腱类型、缝合方式、钙化性肌腱炎、肩峰下滑膜清理、肩峰成型、肱二头肌长头腱切断、Cofield肩袖损伤分型、锚钉数量及缝合肌腱数量;采用多因素Logistic回归分析肩关节镜下肩袖修复术后发生Ⅰ型复杂区域疼痛综合征的危险因素。结果两组的性别构成、术前VAS评分、术前UCLA肩关节评分(疼痛部分)、Cofield肩袖损伤分型及Goutallier肩袖肌肉脂肪浸润分型比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,女性[OR=3.653(95%CⅠ:1.200,11.121)]、术前高VAS评分[OR=1.609(95%CⅠ:1.115,2.323)]均为肩关节镜下肩袖修复术后发生Ⅰ型复杂区域疼痛综合征的危险因素(P<0.05);肩袖小撕裂[OR=0.177(95%CⅠ:0.038,0.825)]是肩关节镜下肩袖修复术后发生Ⅰ型复杂区域疼痛综合征的保护因素(P<0.05)。结论女性患者及术前疼痛度高的患者肩关节镜下肩袖修复术后发生Ⅰ型复杂区域疼痛综合征的风险较高,肩袖小撕裂的患者肩关节镜下肩袖修复术后发生Ⅰ型复杂区域疼痛综合征的风险较低。肩关节镜下肩袖修复术前应评估上述因素,及早采取应对与干预措施。

关节镜下修复联合关节腔灌注治疗肩袖损伤合并继发性冻结肩的疗效分析

目的探讨关节镜下修复肩袖联合关节腔灌注玻璃酸钠+氨甲环酸+得宝松治疗肩袖损伤合并继发性冻结肩的临床疗效。方法回顾性分析2015年8月-2017年5月该院收治的肩袖损伤合并继发性冻结肩患者41例。其中,男12例,女29例,年龄42～68岁,平均55.5岁,病程6～11个月,主诉肩痛、活动受限,磁共振成像(MRI)提示肩袖有撕裂,全麻下先行手法松解,然后入镜观察,镜下松解,根据肩袖撕裂形态及大小选择相应术式行肩袖缝合,关闭切口后,盂肱关节留置引流管并灌注玻璃酸钠20 mg+氨甲环酸10 ml+得宝松1 ml,肩峰下留置引流管并灌注玻璃酸钠20 mg+氨甲环酸10 ml。术后根据骨质及肩袖撕裂情况,个体化设计康复方案进行患肩功能练习。结果手术均顺利完成,切口均Ⅰ期愈合,1例术后1个月因疼痛未缓解要求再次入院予以消炎止痛、关节腔封闭等治疗并好转出院,其余无相关并发症发生,随访时间平均9个月,术后末次随访时视觉模拟评分(VAS)由术前(7.0±1.2)分下降(1.1±0.1)分。术前:外旋5～50°,平均(29.6±13.4)°;前屈30～135°,平均(82.8±30.4)°,外展30～140°,平均(83.4±29.4)°;术后:外旋25～60°,平均(51.3±8.6)°,前屈85～180°,平均(160.3±22.8)°,外展80～180°,平均(157.1±22.3)°。术前术后VAS评分及活动度比较,差异均有统计学意义(P <0.05)。结论关节镜联合关节腔灌注治疗肩袖损伤合并继发性冻结肩,可有效缓解疼痛,改善关节活动度,加速康复,临床效果满意。

Effect of MgO content in sinter on the softening–melting behavior of mixed burden made from chromium-bearing vanadium–titanium magnetite

The effect of sinter with different MgO contents on the softening-melting behavior of mixed burden made from chro- mium-bearing vanadium-titanium magnetite was investigated. The results show that with increasing MgO content in the sinter, the softening interval and melting interval increased and the location of the cohesive zone shifted downward slightly and became moderately thicker. The softening-melting characteristic value was less pronounced when the MgO content in the sinter was 2.98wt%-3.40wt%. Increasing MgO content in the sinter reduced the content and recovery of V and Cr in the dripped iron. In addition, greater MgO contents in the sinter resulted in the generation of greater amounts of high-melting-point components, which adversely affected the permeability of the mixed burden. When the softening-melting behavior of the mixed burden and the recovery of valuable elements were taken into account, proper MgO con- tents in the sinter and slag ranged from 2.98wt% to 3.40wt% and from 11.46wt% to 12.72wt%, respectively, for the smelting of burden made from chromium-bearing vanadium-titanium magnetite in a blast furnace.

Research progress on advanced rail materials for electromagnetic railgun technology

Electromagnetic railgun attracts more and more attention due to its advantage in speed,cost,and obscurity.It is found that the rail should withstand huge mechanical and thermal shocks during the launching operation.The forms of rail failure are accompanied by gouge,grooving,transition,and arc ablation,etc.The service life of the rail has become a bottleneck restricting the development of electromagnetic railgun technology.A series of researches are carried out to solve rail failure,including analysing the failure mechanism and using various advanced rail materials.This paper provides a comprehensive review of rail materials,including material composition,preparation,microstructure,and properties.We begin from a short background of the requirement of the rail material.Then a detailed investigation of rail materials is described,and the performances of those materials are introduced.Finally,further development prospect of rail material is discussed.

Determination of thickness of wax deposition in oil pipelines using gamma-ray transmission method

Wax deposition in pipelines is a crucial problem in the oil industry.An approach that combines the gammaray transmission method with scanning technology is proposed to detect the thickness of wax deposition.The performance of the method is validated through simulations with MCNP code.An experiment is also carried out with a 300 mCi ^(137)Cs source and a LaBr_3 detector.A good correspondence is observed between the simulation and experimental results.The results indicate that the approach is efficient for detecting the thickness of wax deposition in oil pipelines.

Autophagy-related long non-coding RNA prognostic model predicts prognosis and survival of melanoma patients

BACKGROUND Melanomas are malignant tumors that can occur in different body parts or tissues such as the skin,mucous membrane,uvea,and pia mater.Long non-coding RNAs(lncRNAs)are key factors in the occurrence and development of many malignant tumors,and are involved in the prognosis of some patients.AIM To identify autophagy-related lncRNAs in melanoma that are crucial for the diagnosis,treatment,and prognosis of melanoma patients.METHODS We retrieved transcriptome expression profiles and clinical information of 470 melanoma patients from The Cancer Genome Atlas(TCGA)database.Then,we identified autophagy-related genes in the Human Autophagy Database.Using R,coexpression analysis of lncRNAs and autophagy-related genes was conducted to obtain autophagy-related lncRNAs and their expression levels.We also performed univariate and multivariate Cox proportional risk analyses on the obtained datasets,to systematically evaluate the prognostic value of autophagyrelated lncRNAs in melanoma.Fifteen autophagy-related lncRNAs were identified and an autophagy-related prognostic signature for melanoma was established.The Kaplan-Meier and univariate and multivariate Cox regression analyses were used to calculate risk scores.Based on the risk scores,melanoma patients were randomly divided into high-and low-risk groups.Receiver operating characteristic curve analysis,dependent on time,was performed to assess the accuracy of the prognostic model.At the same time,we also downloaded the melanoma data sets GSE65904,GSE19234,and GSE78220 from the GENE EXPRESSION OMNIBUS database for model verification.Finally,we performed Gene Set Enrichment Analysis functional annotation,which showed that the low and the high-risk groups had different enriched pathways.RESULTS The co-expression network for autophagy-related genes was constructed using R,and 936 lncRNAs related to autophagy were identified.Then,52 autophagy-related lncRNAs were significantly associated with TCGA melanoma patients’survival by univariate Cox proportional risk analysis(P<0.01).Further,the 52 autophagy-related lncRNAs mentioned above were analyzed by multivariate Cox analysis with R.Fifteen lncRNAs were selected:LINC01943,AC090948.3,USP30-AS1,AC068282.1,AC004687.1,AL133371.2,AC242842.1,PCED1B-AS1,HLADQB1-AS1,AC011374.2,LINC00324,AC018553.1,LINC00520,DBH-AS1,and ITGB2-AS1.The P values in all survival analyses using these 15 lncRNAs were<0.05.These lncRNAs were used to build a risk model based on the risk score.Negative correlations were observed between risk scores and overall survival rate in melanoma patients over time.Additionally,the melanoma risk curve and scatter plot analyses showed that the death number increased along with the increase in the risk score.Overall,we identified and established a new prognostic risk model for melanoma using 15 autophagy-related lncRNAs.The risk model constructed with these lncRNAs can help and guide melanoma patient prognosis predictions and individualized treatments in the future.CONCLUSION Overall,the risk model developed based on the 15 autophagy-related lncRNAs can have important prognostic value and may provide autophagy-related clinical targets for melanoma treatment.

Novel blast furnace operation process involving charging with low-titanium vanadium–titanium magnetite carbon composite hot briquette

An innovative process of blast furnace （BF） operation involving charging with low-titanium vanadium-titanium magnetite carbon composite hot briquette （LVTM-CCB） was proposed for utilizing LVTM and conserving energy, In this study, the effect of LVTM-CCB charging ratio on the softening, melting, and dripping behaviors of the mixed burden was explored systemically, and the migration of valu- able elements V and Cr was extensively investigated. The results show that with increasing LVTM-CCB charging ratio, the softening inter- val T40 - T4 increases from 146.1℃ to 266.1℃, and the melting interval To - Ts first decreases from 137.2℃ to 129.5℃ and then increases from 129.5℃ to 133.2℃. Moreover, the cohesive zone becomes narrower and then wider, and its location shifts slightly downward. In addi- tion, the recovery ratios of V and Cr in dripped iron first increase and then decrease, reaching maximum values of 14.552% and 28.163%, respectively, when the charging ratio is 25%. A proper LVTM-CCB charging ratio would improve the softening--melting behavior of the mixed burden; however, Ti（C,N） would be generated rapidly in slag when the charging ratio exceeds 25%, which is not favorable for BF op- eration. When considering the comprehensive softening-melting behavior of the mixed burden and the recovery ratios of V and Cr, the rec- ommended LVTM-CCB charging ratio is 20%.

Effect of nonpeptide NK1 receptor antagonist L-703,606 on the edema formation in rats at early stage after deep partial-thickness skin scalding

Objective:To investigate the effect and the relevant potential mechanism of nonpeptide neurokinin 1(NK1) receptor antagonist L-703,606 in the edema formation after burn injury. Method:1.-703,606 treatment was performed in Sprague-Dawley(SD) rats at early stage after deep partial-thickness skin scalding.One hundred and fifty two adult male SI) rats were used in the study and randomly divided into sham scald(SS,n=8),scald control(SC,n=48),and L-703,606 treatment(IT,n=48) groups.The rats in SC and LT groups were subjected to 20%total body surface area(TBSA) deep partial-thickness skin scalding.Modified Evans blue extravasation, tracing electron microscopy by lanthanum nitrate and mean water content assay were employed to observe and detect the changes of vascular permeability,ultrastructure and edema formation in adjacent tissue to the wounds and in the jejuna of rats at early stage(72 h) after scald.Results: The pathological increase of vascular permeability in the periwound tissue and jejunum of rats in LT group were significantly lower than that in SC group(P【0.01),and recuperated earlier. Meanwhile,the changes of water contents of corresponding tissues in LT group were lighter than those in SC group(P【0.01).The ultrastructural changes of the microvessels in the peri-wound tissue of LT group showed that the junctions between microvascular endothelium cells were more narrow than those of SC group,moreover,and the number of opening and the engorgement and cavitation of the vascular endothelium cells decreased,the areosis and edema in perivascular tissue lightened,and the precipitation of the high eletron density lanthanum tracing agent in the interspace of the tissue decreased significantly in LT group.Conclusions:It is concluded that nonpeptide NK1-receptor antagonist L-703,606 could lighten the vascular permeability and edema formation in the periwound tissue and jejunum,and accelerate the normalization process of pathological changes in the tissues of rats after scald.

Detection of heavy metals in aqueous solution using PGNAA technique

A prompt gamma neutron activation analysis setup was developed for heavy metal detection in aqueous solutions with a 300 m Ci241Am-Be neutron source and a4 4 inch(diameter height) BGO detector. In the present work, heavy metals, including Mn, Cu, Ni, Cr and Zn, were measured by the setup. The minimum detectable concentrations of Mn, Cu, Ni, Cr and Zn were 246.6, 391.2, 218.1,301.5 and 2804.1 ppm, respectively. The minimum detectable concentration of each element and the linearity response between the characteristic peak counts and elements concentrations have been studied. And the results showed that all heavy metals had a good linear relationship between characteristic peak counts and concentrations.

Simulations of thermal conductance across tilt grain boundaries in graphene

Non-equilibrium molecular dynamics （MD） method was performed to simulate the thermal transporta- tion process in graphene nanoribbons （GNRs）. A convenient way was conceived to introduce tilt grain boundaries （GBs） into the graphene lattice by repetitive removing C atom rows along certain directions. Comprehensive MD simulations reveal that larger-angle GBs are effective thermal barriers and substantially reduce the average thermal conductivity of GNRs. The GB thermal conductivity is ~ 10 W-m-1 .K-l for a bicrystal GNR with a misorientation of 21.8%, which is -97 % less than that of a prefect GNR with the same size. The total thermal resistance has a monotonic dependence on the den- sity of the 5-7 defects along the GBs. A theoretical model is proposed to capture this relation and resolve the contribu- tions by both the reduction in the phonon mean free path and the defect-induced thermal resistance.

The Variability of the Narrow-line Seyfert 1 Galaxies from the Pan-STARRS's View

By means of the data sets from the Pan-STARRS1 survey, we have systematically examined the relationship between the variability characteristics and the physical parameters of the largest NLS1 galaxy sample up to now.The results are summarized as follows:(1). We find significant anti-correlations between variability amplitude and absolute magnitude in g, r, i, z and y bands, which are consistent with the results in previous works.(2) The correlations between the variability amplitude in optical band and many physical parameters(e.g., λL(5100 A),black hole mass, Eddington ratio, R;and R;) are investigated. The results show the variability amplitude is significantly anti-correlated with L(5100 A), MBH, Eddington ratio and R_(4570), but positively correlated with R;.The relation could be explained by the simple standard accretion disk model.(3) We further investigate the relationship between optical variability and radio luminosity/radio-loudness. The results present weak positive correlation in g and r bands, but insignificant correlation in i, z and y bands. The large error of the approximate fraction of the host galaxy in i, z and y bands may lead to insignificant correlations.

The mid-infrared variability of the SDSS optical quasars

Based on the Seventh Data Release(DR7) quasar catalog from the Sloan Digital Sky Survey,we investigate the variability of optical quasars in W1,W2,W3 and W4 bands of the Wide-field Infrared Survey Explorer(WISE) and the Near-Earth Object Wide-field Infrared Survey Explorer(NEOWISE).Adopting the structure function(SF) method,we calculate the SF(δt = 1 yr) which shows no obvious correlations with the bolometric luminosity,the black hole mass and the Eddington ratio.The ensemble SFs in W1 and W2 bands show that the SF slopes are steeper than those in previous studies which may be caused by different cadence and observational epoch number.We further investigate the relation of variability amplitude σmbetween mid-infrared band and optical band,but no obvious correlation is found.No correlation is found between W1–W2 and g-r color.We think that the mid-infrared emission of quasars may be smoothed out by the extended dust distribution,thus leading to no obvious correlation.For the radio-loud quasar sub-sample,we further analyze the relation between the variability amplitude in the mid-infrared band and the radio luminosity at 6 cm,but no obvious correlations are found,which indicate the mid-infrared emission contributed from the synchrotron radiation of the relativistic jet is very weak.

Collembolans accelerate the dispersal of antibiotic resistance genes in the soil ecosystem

Soils have become an important sink for antibiotic resistance genes(ARGs).To better understand the impacts of ARGs on the soil ecosystem,the transport of ARGs is a basic question.So far,however,the role of soil animals in the dispersal of ARGs is not understood.Here,two treatments(without collembolans and with collembolans)were established,each treatment included unamended and manure-amended soil,and soil samples were collected at 14,28 and 56 days after incubation.The effects of the collembolan Folsomia candida on dispersal of ARGs in the soil ecosystem were explored using high-throughput qPCR combined with Illumina sequencing.As the culture time increased,more shared ARGs and OTUs were detected between the unamended and manured soil,especially in the treatment with collembolans.Vancomycin,aminoglycoside and MLSB genes may have been more readily transported by the collembolan.On the 28th day after incubation,a high abundance of mobile genetic elements(MGEs)was found in the treatment with collembolans.These results clearly reveal that collembolans can accelerate the dispersal of ARGs in the soil ecosystem.Procrustes analysis and the Mantel test both indicate that soil bacterial communities were significantly correlated with ARG profiles.Furthermore,partial redundancy analysis indicates that soil bacterial communities can explain 41.28% of the variation in ARGs.These results suggest that the change of soil microbial community have an important contribution to the dispersal of ARGs by the collembolan.

Microstructure and properties of TiB_(2)-Ni coatings with different binder phase contents deposited by HVOF spray process

TiB_(2)–Ni coatings with different binder phase contents were sprayed on Q235 substrate by a high-velocity oxygen-fuel(HVOF)method using ball-milled powders.The microstructure,phase compositions,as well as thermal shock behavior,abrasive wear,and corrosion resistance to molten Al-12.07 wt%Si alloy performances of as-sprayed coatings were investigated.The results show that the three TiB_(2)–Ni coatings structure is dense with low porosity,and the main phase compositions of the coatings are TiB_(2) and Ni similar to those of original powder.The coatings that have superior performance of thermal shock resistance have good bond to the substrate with no change in thick-ness and microstructure of coatings.Meanwhile,the coat-ings also have good durability in the molten Al-12.07 wt%Si after 60-h immersion test.And the mass loss of Q235 steel is five times as much as that of TiB_(2)–50Ni coatings after abrasive wear test.

Current status and development trends of innovative blast furnace ironmaking technologies aimed to environmental harmony and operation intellectualization

Blast furnace （BF） ironmaking is dominant for reducing pollution emission and energy consumption in iron and steel industry, Under the increasingly strict environmental pressure, some innovative tech nologies of BF ironmaking for environmental protection have been developed and applied in actual op- erating facilities. The current state of BF ironmaking in Europe, America, Japan, and China were briefly overviewed. Moreover, some innovative BF ironmaking technologies aiming at environmental harmony and operation intellectualization in the world, such as waste gas recycling sintering, BF op eration with coke oven gas injection, ferro coke, lime coating coke, BF visualization and intellectuali zation, were roundly summarized. Finally, some discussion on the technologies was carried out and the development trends of BF ironmaking were pointed out. The review could provide references and supports for the progress of environment friendly technologies of BF ironmaking, thereby promoting their practical applications and achieving sustainable development of BF ironmaking, especially for Chinese ironmaking industry.

Modeling assessment of recovering iron from red mud by direct reduction： magnetic separation based on response surface methodology

Red mud, the waste generated during alumina production, contains iron and other valuable metals. To recover the iron efficiently from red mud, a three-factor five-level central composite design in response surface methodology was used to study the effects of process parameters, such as FC/O （the molar ratio of fixed carbon in coal to reducible oxygen of iron oxide in red mud）, reduction temperature, reduction time, and their interaction on the iron recovery rate and total iron content in magnetic product obtained from the process of direct reduction-magnetic separation. The relevant assessment model was established. The model could predict the changing rules of iron recovery rate and total iron content in the magnetic product affected by the process parameters. The results show that the iron recovery rate is significantly influenced by three factors and reduction temperature plays the most important role. The iron recovery rate and total iron content in magnetic product could be up to 98.37 and 82.52%, respectively, under the numerically optimal process parameters condition of reduction temperature of 1400 ℃, FC/O of 0.80 and reduction time of 100 min obtained by the assessment model. The predicted values are in good agreement with the experimental values.

Temporal and spatial variation in the environmental impacts of China’s resource extraction at the provincial scale

Introduction:Over the past two decades,China has experienced rapid economic development,which has not only led to a rapid increase in the use of raw materials but has also created environmental problems.This research analyzes the environmental impacts of resource extraction in China at the provincial level,and fully considers the environmental impact of various resources extraction.In addition,it is the first time to quantitatively study the spatial pattern and evolution characteristics of the environmental impacts of China’s resource extraction from multiple perspectives by means of spatial visualization.Outcomes:The results showed that the center of gravity of abiotic depletion potential(ADP)moved northwest,respiratory inorganics(RI)moved southwest and global warming potential(GWP)moved west.The results of the standard deviation ellipse showed that RI and GWP varied over time and space,while ADP showed a discrete trend.In addition,the distribution of the four in the northeast-southwest direction became more prominent.Conclusion:To mitigate the environmental impacts of resource extraction,we recommend that regional governments implement measures to control environmental impacts in the provinces within the distributed ellipse and design targeted policies based on actual conditions.

Shift in the percolation threshold of compressed composites—A 3D Monte Carlo simulation

The shift in the percolation threshold of compressed composites was studied by a 3D continuum percolation model. A Monte Carlo (MC) method was employed in the simulations. The percolation threshold was found to rise with the compression strain, which captures the basic trend in compression-induced conductivity variation from the experiments. Both fiber bending and texture formation contribute to the percolation threshold. The results suggest that fillers with a high aspect ratio are more desirable for sensor and electrical switch applications.

帕瑞昔布对过氧化氢诱导的原代星形胶质细胞氧化应激的保护作用（英文）

目的:评估帕瑞昔布对过氧化氢诱导的大鼠原代星形胶质细胞氧化应激状态的保护作用,并初步探讨其作用机制。创新点:首次在大鼠原代星形胶质细胞中证实帕瑞昔布对过氧化氢诱导的氧化应激具有保护作用,且此作用可能与Bax、Bcl-2和BDNF的失调有关。方法:设立如下四组对照:(1)阴性对照组;(2)100μmol/L H_2O_2处理组(处理时间为24 h);(3)80μmol/L帕瑞昔布处理组;(4)160μmol/L帕瑞昔布处理组(第三和第四组先用帕瑞昔布处理24 h,再用100μmol/L H_2O_2处理24 h)。用荧光显微镜观察星形胶质细胞的形态,用MTT法检测星形胶质细胞的存活率,用荧光探针二氯荧光黄双乙酸盐(DCDHF-DA)检测星形胶质细胞内氧自由基的含量,并用碘化丙啶(PI)染色检测细胞的凋亡状态。最后用反转录酶聚合酶链反应(RT-PCR)和蛋白质印迹(Western blot)检测Bax、Bcl-2和BDNF三种蛋白在4组中的表达水平。结论:H_2O_2处理可以导致星形胶质细胞的形态发生改变(图1)和存活率降低(图2),提高星形胶质细胞内的氧自由基水平(图3),同时诱导细胞凋亡(图4)。然而,所有这些变化都可以被帕瑞昔布逆转。此外,我们发现,Bax、Bcl-2和BDNF的表达水平在H_2O_2处理时失调,而在帕瑞昔布预处理时恢复正常。综上所述,帕瑞昔布对H_2O_2诱导的氧化应激具有保护作用。