Cytochrome P450 2E1 RsaI/PstI and DraI Polymorphisms Are Risk Factors for Lung Cancer in Mongolian and Han Population in Inner Mongolia

Objective： To explore the relationship between cytochrome P450 2E1 （CYP2E1） RsaI/PstI and DraI polymorphism and lung cancer susceptibility in Mongolian and Han population in Inner Mongolia of China. Methods： CYP2E1 RsaI/PstI and DraI polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism in 64 lung cancer patients, 150 healthy Mongolian and 150 healthy Han individuals. The distribution of genotype and allele frequencies of CYP2E1 RsaI/PstI and DraI polymorphisms were studied. Results： The risk of lung cancer was increased in individuals with CYP2E1 （cl/cl） and CYP2E1 （DD） with OR values of 2.431 （95%CI=1.082-5.460） and 2.778 （95%CI=1.358-5.683） respectively （P0.05）. When CYP2E1 RsaI/PstI and DraI polymorphisms were combined, the risk of lung cancer was reduced in individuals with CYP2E1 （cl/c2＋c2/c2 and DD＋CC） with OR values of 0.233 （95%CI=0.088-0.615, P0.05）. In smokers, the susceptibility to lung cancer was higher in the individuals with CYP2E1 （c1/c1） and CYP2E1 （DD） than in the individuals with c2 and C allele （P0.05, OR=2.643 and 4.308 respectively）. There was no significant difference in distribution of CYP2E1 genotype frequency between healthy Mongolian, Han population and lung cancer patients, healthy controls in Inner Mongolia. Conclusion： CYP2E1 （c1/c1） and CYP2E1 （DD） are predisposing factors of lung cancer in population in Inner Mongolia. CYP2E1 （c2﹢C） co-mutation may decrease the risk of lung cancer. Smoking exerts synergetic effect with CYP2E1 （c1/c1） and CYP2E1 （DD） on the occurrence of lung cancer.

Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese

BACKGROUND Hypertension(HTN)and type 2 diabetes mellitus(T2DM)are often coincident,and each condition is considered a risk factor for the other.Both occur frequently in the Inner Mongolia region of China.The reasons for differences in risk between Han and Mongolian ethnic groups are not known.The LEPR gene and its polymorphism,rs1137101(Gln223Arg),are both considered risk factors for HTN and T2DM,but any role of rs1137101 in the occurrence of HTN+T2DM remains unclear for Mongolian and Han populations in the Inner Mongolia region.AIM To investigate the relationship between rs1137101 and the occurrence of HTN with T2DM in Mongolian and Han populations in Inner Mongolia METHODS A total of 2652 subjects of Han and Mongolian ethnic origins were enrolled in the current study,including 908 healthy controls,1061 HTN patients and 683 HTN patients with T2DM.RESULTS The association between the rs1137101 polymorphism and HTN with T2DM was analyzed,and differences between Han and Mongolian individuals assessed.There was a significant correlation between rs1137101 and HTN(co-dominant,dominant,over-dominant and log-additive models)and HTN+T2DM(co-dominant,dominant,over-dominant and log-additive models)after adjustment for sex and age in individuals of Mongolian origin.rs1137101 was significantly associated with HTN(co-dominant,recessive and log-additive models)and HTN+T2DM(codominant,dominant,over-dominant and log-additive models)in the Han Chinese population.CONCLUSION Mongolian and Han subjects from Inner Mongolia with HTN who had rs1137101 were protected against the development of T2DM.Allele A has the opposite impact on the occurrence of HTN in Mongolian and Han Chinese populations.

Secure Speculation via Speculative Secret Flow Tracking

Speculative execution attacks can leak arbitrary program data under malicious speculation,presenting a severe security threat.Based on two key observations,this paper presents a software-transparent defense mechanism called speculative secret flow tracking(SSFT),which is capable of defending against all cache-based speculative execution attacks with a low performance overhead.First,we observe that the attacker must use array or pointer variables in the victim code to access arbitrary memory data.Therefore,we propose a strict definition of secret data to reduce the amount of data to be protected.Second,if the load is not data-dependent and control-dependent on secrets,its speculative execution will not leak any secrets.Thus,this paper introduces the concept of speculative secret flow to analyze how secret data are obtained and propagated during speculative execution.By tracking speculative secret flow in hardware,SSFT can identify all unsafe speculative loads(USLs)that are dependent on secrets.Moreover,SSFT exploits three different methods to constrain USLs’speculative execution and prevent them from leaking secrets into the cache and translation lookaside buffer(TLB)states.This paper evaluates the performance of SSFT on the SPEC CPU 2006 workloads,and the results show that SSFT is effective and its performance overhead is very low.To defend against all speculative execution attack variants,SSFT only incurs an average slowdown of 4.5%(Delay USL-L1Miss)or 3.8%(Invisible USLs)compared to a non-secure processor.Our analysis also shows that SSFT maintains a low hardware overhead.

An improved method for evaluating the rotational speed stability of a hydro-viscous clutch in mixed lubrication

Rotational speed stability is an important evaluation indicator of the performance of a hydro-viscous clutch(HVC).To improve the rotational speed stability of HVCs in mixed lubrication and the running condition of the friction pairs,the speed stability of an HVC in mixed lubrication was studied.To this end,the friction coefficients of both copper-based and paper-based friction pairs were experimentally tested using an MM1000-III wet friction machine.Theoretically,a torsional vibration model of the system is presented.The phase plane analysis method is applied to evaluate the stability of the torsional vibration model,where a critical negative gradient(CNG)is defined.The results show that the friction coefficient in mixed lubrication is an important parameter for the stability of the rotational speed.The system will be unstable when the negative gradient of the friction coefficient-slip speed is larger than the CNG.According to the definition of the CNG,suggestions regarding choice of friction pairs are made to improve the rotational speed stability of an HVC in mixed lubrication.