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Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus 被引量:1
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作者 hong-xiao wu Xiao-Yan Ding +4 位作者 Ya-Wen Xu Ming-Hua Yu Xiao-Mi Li Na Deng Jing-Long Chen 《World Journal of Gastroenterology》 SCIE CAS 2024年第8期843-854,共12页
BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment responses.AIM To investigate efficacies and safety of the combination of PD-1 inhi... BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment responses.AIM To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with PVTT.METHODS From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan Hospital.They were distributed to either the PTL or TACE/Lenvatinib(TL)group.The median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary endpoints.RESULTS Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)groups.For a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),res-pectively.Moreover,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)patients.There were no treatment-related deaths or differences in adverse events in either group.CONCLUSION A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ. 展开更多
关键词 Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus
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Current Status and Prospect of Stent Placement for May-Thurner Syndrome 被引量:3
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作者 Qin LIU Fang LIU +4 位作者 Ping LÜ hong-xiao wu Pin YE Yun YOU Zhong YAO 《Current Medical Science》 SCIE CAS 2021年第6期1178-1186,共9页
Stent implantation has been proven to be safe and has become the first-line intervention for May-Thumer syndrome(MTS),with satisfactory mid-term patency rates and clinical outcomes.Recent research has demonstrated tha... Stent implantation has been proven to be safe and has become the first-line intervention for May-Thumer syndrome(MTS),with satisfactory mid-term patency rates and clinical outcomes.Recent research has demonstrated that catheter-directed thrombolysis is the preferred strategy when MTS is combined with deep vein thrombosis after self-expanding stent placement.However,the stent used for the venous system was developed based on the experience obtained in the treatment of arterial disease.Consequently,relatively common corresponding complications may come along later,which include stent displacement,deformation,and obstruction.Different measures such as adopting a stent with a larger diameter,improving stent flexibility,and increasing stent strength have been employed in order to prevent these complications.The ideal venous stent is presently being evaluated and will be introduced in detail in this review. 展开更多
关键词 May-Thumer syndrome deep vein thrombosis post-thrombotic syndromes STENT stent placement
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Two Structure-Preserving-Doubling Like Algorithms to Solve the Positive Definite Solution of the Equation X-A^(H)X^(-1)A=Q 被引量:1
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作者 Xiao-Xia Guo hong-xiao wu 《Communications on Applied Mathematics and Computation》 2021年第1期123-135,共13页
In this paper,we study the nonlinear matrix equation X-A^(H)X^(-1)A=Q,where A,Q∈C^(n×n),Q is a Hermitian positive definite matrix and X∈C^(n×n)is an unknown matrix.We prove that the equation always has a u... In this paper,we study the nonlinear matrix equation X-A^(H)X^(-1)A=Q,where A,Q∈C^(n×n),Q is a Hermitian positive definite matrix and X∈C^(n×n)is an unknown matrix.We prove that the equation always has a unique Hermitian positive definite solution.We present two structure-preserving-doubling like algorithms to find the Hermitian positive definite solution of the equation,and the convergence theories are established.Finally,we show the effectiveness of the algorithms by numerical experiments. 展开更多
关键词 Positive definite solution Structure-preserving-doubling like algorithm CONVERGENCE Numerical experiment
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