Herein, an efficient molecular oxygen-mediated method for the selective hydroxyalkylation and alkylation of quinoxalin-2(1 H)-ones with alkylboronic acids under transition-metal free conditions has been developed. Thi...Herein, an efficient molecular oxygen-mediated method for the selective hydroxyalkylation and alkylation of quinoxalin-2(1 H)-ones with alkylboronic acids under transition-metal free conditions has been developed. This strategy demonstrates a broad scope of quinoxalin-2(1 H)-ones and alkylboronic acids, giving3-hydroxyalkylquinoxalin-2(1 H)-ones and 3-alkylquinoxalin-2(1 H)-ones in moderate-to-good yield. Control experiments reveal that a radical pathway is involved.展开更多
基金Natural Science Foundation of Zhejiang Province(No. LY21B060009) for financial support。
文摘Herein, an efficient molecular oxygen-mediated method for the selective hydroxyalkylation and alkylation of quinoxalin-2(1 H)-ones with alkylboronic acids under transition-metal free conditions has been developed. This strategy demonstrates a broad scope of quinoxalin-2(1 H)-ones and alkylboronic acids, giving3-hydroxyalkylquinoxalin-2(1 H)-ones and 3-alkylquinoxalin-2(1 H)-ones in moderate-to-good yield. Control experiments reveal that a radical pathway is involved.
