Engineering heterointerfaces coupled with oxygen vacancies in lanthanum–based hollow microspheres for synergistically enhanced oxygen electrocatalysis

The development of high–efficiency and low–cost bifunctional oxygen electrocatalysts is critical to enlarge application of zinc–air batteries(ZABs). However, it still remains challenges due to their uncontrollable factor at atomic level during the catalysts preparation, which requires the precise regulation of active sites and structure engineering to accelerate the reaction kinetics for both oxygen reduction reaction(ORR) and oxygen evolution reaction(OER). Herein, a novel Co–doped mixed lanthanum oxide and hydroxide heterostructure(termed as Co–La MOH|OV@NC) was synthesized by pyrolysis of La–MOF–NH_(2) with spontaneous cobalt doping. Synergistic coupling of its hollow structure, doping effect and abundant oxygen vacancies creates more active sites and leads to higher electroconductivity, which contribute to the better performance. As employed as a bifunctional oxygen electrocatalyst, the resulting 3 Co–La MOH|OV@NC exhibits superior electrocatalytic activity for both ORR and OER. In assembled ZAB, it also demonstrates an excellent power density of 110.5 m W cm^(-2), high specific capacity of 810 m Ah g_(Zn)^(-1), and good stability over 100 h than those of Pt/C + RuO_(2). Density functional theory(DFT) calculation reveals that the heterointerfaces coupled with oxygen vacancies lead to an enhanced charge state and electronic structure, which may optimize the conductivity, charge transfer, and the reaction process of catalysts.This study provides a new strategy for designing highly efficient bifunctional oxygen electrocatalysts based on rare earth oxide and hydroxides heterointerface.

Microarray gene expression analysis of chemosensitivity for docetaxel,cisplatin and 5-fluorouracil(TPF)combined chemotherapeutic regimen in hypopharyngeal squamous cell carcinoma

Objective: To screen out a set of candidate genes which could help to determine whether patients with hypopharyngeal squamous cell carcinoma (HSCC) could benefit from docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy. Methods: Gene-expression profiles in 12 TPF-sensitive patients were compared to 9 resistant controls by microarray analysis. Subsequently, expression levels of potential biomarkers in chemosensitive cell line FaDu after TPF treatment were observed by quantitative real-time polymerase chain reaction (qRT-PCR). Results: Through microarray analysis, 1,579 differentially expressed genes were identified, of which 815 were up-regulated in TPF chemotherapy-responsive tissues whereas 764 were down-regulated. Gene ontology (GO) analysis suggested these genes participating in physiological processes including transcription and its regulation, cellular signal transduction and metabolic process. Additionally, Kyoto Encyclopedia of Genes and Genomes (KEGG) database revealed that MAPK and Jat/STAT signaling pathways occupied important roles in TPF chemotherapeutic sensitivity. Moreover, in vitro cell culture experiments revealed the expression alternations of IL-6, MAPK14, JUN, CDK5 and CAMK2A exposed to TPF treatment by qRT-PCR, whilst providing an insight into the mechanism underlying TPF chemotherapeutic response in HSCC. Conclusions: These results provided a battery of genes related to TPF chemotherapeutic sensitivity and might act as molecular targets in HSCC treatment. Moreover, these candidate biomarkers could contribute to HSCC individualized treatment.

Exploring Senior High School Students’ English Academic Resilience in the Chinese Context

While academic resilience has been a hot topic in positive psychology,there is still scope for researchers to explore it in the field of applied linguistics.Drawing on the framework of L2(second language) learners’ resilience proposed by T.Y.Kim and Y.K.Kim(2017),the current study aims to examine senior high school students’ English academic resilience(EAR) and its relationship to their English achievement(EA).This study comprises a survey of 454 senior high school students.Follow-up interviews were carried out to triangulate the quantitative findings.The descriptive results demonstrate that students’ EAR is above the average,and its five subscales obtain medium to medium-higher levels due to the mean scores.It shows that students have good EAR that enables them to deal with academic adversity.The correlational analysis shows a low positive correlation between EAR and EA in general,and the subscales share medium to low correlations with students’ EA.EAR has a certain influence on EA,but the correlation may be influenced by other learner variables.Based on the results,suggestions on improving students’ EAR are provided.

Introducing Positive Psychology in Applied Linguistics:Asian Perspectives

It is not so long ago that research into foreign language education was concerned with little beyond language and teaching;foreign language education was very much a teachercentered activity and the research agenda reflected this. Language education was regarded as a matter of applying the appropriate teaching technique to the language point being taught in the assumption that learning would automatically occur;research was there to serve this simplistic model of language education as a unidirectional transfer of mental knowledge.

Perioperative sintilimab and neoadjuvant anlotinib plus chemotherapy for resectable non-small-cell lung cancer:a multicentre,open-label,single-arm,phase 2 trial(TD-NeoFOUR trial)

This open-label,single-arm,phase 2 trial evaluated the efficacy and safety of neoadjuvant sintilimab combined with anlotinib and chemotherapy,followed by adjuvant sintilimab,for resectable NSCLC.Forty-five patients received anlotinib(10 mg,QD,PO,days 1-14),sintilimab(200 mg,day 1),and platinum-based chemotherapy of each three-week cycle for 3 cycles,followed by surgery within 4-6 weeks.Adjuvant sintilimab(200 mg)was administered every 3 weeks.The primary endpoint was achieving a pathological complete response(pCR).From June 10,2021 through October 10,2023,45 patients were enrolled and composed the intention-to-treat population.Twenty-six patients(57.8%)achieved pCR,and 30(66.7%)achieved major pathological response(MPR).Forty-one patients underwent surgery.In the per-protocol set(PP set),63.4%(26/41)achieved pCR,and 73.2%achieved MPR.The median event-free survival was not attained(95%CI,25.1-NE).During the neoadjuvant treatment phase,grade 3 or 4 treatment-related adverse events were observed in 25 patients(55.6%),while immune-related adverse events were reported in 7 patients(15.6%).We assessed vascular normalization and infiltration of immune-related cells by detecting the expression of relevant cell markers in NSCLC tissues with mIHC.Significant tumor microenvironment changes were observed in pCR patients,including reduced VEGF+cells and CD4+Foxp3+Treg cells,and increased perivascular CD4+T cells,CD39+CD8+T cells,and M1 macrophages.In conclusion,perioperative sintilimab and neoadjuvant anlotinib plus chemotherapy achieved pCR in a notable proportion of patients with resectable NSCLC and were associated with profound changes in the tumour microenvironment(ClinicalTrials.gov NCT05400070).

Uncovering the Mediating Role of Teacher Anxiety on the Relationship between Teacher Self-Efficacy and Teacher Work Engagement in the Online Context

Background:With the widespread adoption of synchronous online instruction,concerns have arisen regarding teachers’professional functioning in this new context.While previous studies have extensively explored teacher psychology,the control-value theory(CVT)provides additional insights into teachers’experiences.As limited research has specifically addressed the psychological experiences of primary school teachers in online teaching settings,this study investigated the relationships among teachers’online self-efficacy,anxiety,and engagement through the CVT framework.Methods:This study employed a quantitative research design,conducting a questionnaire survey of 1037 Chinese primary school teachers recruited through convenience and snowball sampling.Exploratory Structural Equation Modelling was first applied to validate the constructs.Subsequently,a structural equation model was developed and tested to examine the relationships between the key variables.A mediation analysis further explored the indirect effect of teacher self-efficacy on engagement through anxiety,consistent with CVT propositions.Results:Structural Equation Modelling results revealed that teachers’self-efficacy was a significant predictor of both anxiety(β=−0.165,p<0.001)and engagement(β=0.707,p<0.001).Anxiety also significantly predicted engagement(β=−0.097,p<0.001).Mediation analysis further demonstrated that anxiety partially mediated the relationship between self-efficacy and engagement(β=0.016).Conclusion:While anxiety can impede teachers’full engagement in online teaching,self-efficacy appears to buffer against anxiety’s negative effects,ultimately enhancing teaching effectiveness.These findings offer valuable insights for improving teachers’online teaching experiences and optimizing educational outcomes in digital environments.

鼻腔鼻窦IgG4相关性疾病10例临床病理学分析

目的探讨鼻腔鼻窦IgG4相关性疾病(IgG4-RD)的临床病理特征、诊断及鉴别诊断。方法回顾性分析2016年3月至2021年3月, 以鼻炎或鼻肿物为主诉, 在首都医科大学附属北京同仁医院就诊并行鼻黏膜活检的患者。依据2019年美国风湿病学会(ACR)/欧洲抗风湿病联盟(EULAR)制定的IgG4-RD国际分类诊断标准筛选出鼻腔鼻窦IgG4-RD患者10例, 观察分析临床特征、组织病理学形态及IgG和IgG4免疫组织化学表达情况。结果 10例患者中男性5例, 女性5例, 年龄范围30~71岁, 中位年龄52.7岁。6例患者可见鼻息肉/鼻肿物, 4例伴泪腺肿胀。4例血清IgG和IgG4浓度升高。镜下10例均表现为鼻腔或鼻窦黏膜大量淋巴细胞和浆细胞浸润以及不同程度的纤维化, 4例可见闭塞性血管炎。鼻黏膜IgG4+浆细胞计数均>10个/HPF, 平均数为67个/HPF, 严重纤维化病例IgG4计数明显减少, 6例IgG4+/IgG+浆细胞>40%。结论鼻腔鼻窦IgG4-RD是系统性疾病的局部表现, 是IgG4-RD很少累及的部位, 确诊需结合临床症状、影像学、血清学及组织病理学评分结果。其中, 组织病理学具有核心诊断价值, 对于无法取得活检标本的病例, IgG4血清学及影像学具有重要诊断价值。