Cancer stem cells (CSCs) are largely responsible for the formation of tumor heterogeneity and tumor’s resistance to traditional treatments such as chemotherapy due to its self-renew capability and multi-lineage diffe...Cancer stem cells (CSCs) are largely responsible for the formation of tumor heterogeneity and tumor’s resistance to traditional treatments such as chemotherapy due to its self-renew capability and multi-lineage differentiation potential (1)However, it remains elusive how the CSCs maintain their stemness, thus restricting the development of therapeutic treatments specifically targeting the CSCs.展开更多
基金supported by National Key Scientific Program of China (2016YFA0100502 to X.S.)the National Natural Science Foundation of China (81701765 to J.C.)Anhui Provincial Natural Science Foundation (1808085MH295 to J.C.)
文摘Cancer stem cells (CSCs) are largely responsible for the formation of tumor heterogeneity and tumor’s resistance to traditional treatments such as chemotherapy due to its self-renew capability and multi-lineage differentiation potential (1)However, it remains elusive how the CSCs maintain their stemness, thus restricting the development of therapeutic treatments specifically targeting the CSCs.
