Electromagnetic wave(EMW)-absorbing materials have considerable capacity in the military field and the prevention of EMW radiation from harming human health.However,obtaining lightweight,high-performance,and broadband...Electromagnetic wave(EMW)-absorbing materials have considerable capacity in the military field and the prevention of EMW radiation from harming human health.However,obtaining lightweight,high-performance,and broadband EMW-absorbing material remains an overwhelming challenge.Creating dielectric/magnetic composites with customized structures is a strategy with great promise for the development of high-performance EMW-absorbing materials.Using layered double hydroxides as the precursors of bimetallic alloys and combining them with porous biomass-derived carbon materials is a potential way for constructing multi-interface heterostructures as efficient EMW-absorbing materials because they have synergistic losses,low costs,abundant resources,and light weights.Here,FeNi alloy nanosheet array/Lycopodium spore-derived carbon(FeNi/LSC)was prepared through a simple hydrothermal and carbonization method.FeNi/LSC presents ideal EMW-absorbing performance by benefiting from the FeNi alloy nanosheet array,sponge-like structure,capability for impedance matching,and improved dielectric/magnetic losses.As expected,FeNi/LSC exhibited the minimum reflection loss of-58.3 dB at 1.5 mm with 20wt%filler content and a widely effective absorption bandwidth of 4.92 GHz.FeNi/LSC composites with effective EMW-absorbing performance provide new insights into the customization of biomass-derived composites as high-performance and lightweight broadband EMW-absorbing materials.展开更多
Objective: The significance of isolated high-grade prostatic intraepithelial neoplasia in initial biopsy as an predic-tor for prostate cancer has been extensively research, and the true relationship remnant is no clea...Objective: The significance of isolated high-grade prostatic intraepithelial neoplasia in initial biopsy as an predic-tor for prostate cancer has been extensively research, and the true relationship remnant is no clear till now. The aim of this study is to evaluate prediction value of cancer on repeat biopsy in patients with high-grade prostatic intraepithelial neoplasia, using multivariate analysis. Methods: Thirty-eight men with a diagnosis of isolated high-grade prostatic intraepithelial neo-plasia in initial needle biopsy were studies, in the Fist Affiliated Hospital of Medical School of Xi'an Jiaotong University, from January 2003 to March 2009. These samples were using immunostaining of p63 and 34βE12 and P504s, with a median fol-low-up of 525 (range, 7 to 1650) days, and to researched the incidence of subsequent prostate cancer, and to predicted the risk of prostate cancer in clinicopathological parameters of isolated high-grade prostatic intraepithelial neoplasia on repeat biopsies by logistic regression analysis. Results: There were 10 of 38 (26.3%) men with prostate cancer on repeat biopsies after diagnosis isolated high-grade prostatic intraepithelial neoplasia in initial biopsy, of the rates of prostate cancer were 80% for micropapillary and 75% for cribriform high-grade prostatic intraepithelial neoplasia (P < 0.05), respectively. The positive cores of isolated high-grade prostatic intraepithelial neoplasia was the important for the risk of prostate cancer using Multi-factor logistic regression analysis. The time range in 30 to 690 days was stronger risk for prostate cancer detection after diagnosis isolated HGPIN in initial biopsy. p63 and 34βE12 were disrupted positive expression, and P504S was weak posi-tive expression in the 61% isolated high-grade prostatic intraepithelial neoplasia. Conclusion: Isolated high-grade prostatic intraepithelial neoplasia on repeat biopsy conferred a 26.3% risk of prostate cancer, and this risk level is lower than the previ-ously reported risk of 24% to 58%. The number of positive cores and the histopathological pattern with high-grade prostatic intraepithelial neoplasia on initial biopsy was significantly associated with the risk of cancer.展开更多
Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to s...Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular functions.Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell death.Ferroptosis is a recently discovered form of iron-dependent programmed cell death.The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression.However,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well understood.Here,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process.Additionally,we provided a detailed overview of agents used to induce cancer ferroptosis.We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell killing.The combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.展开更多
Although VB-Group transition metal disulfides(TMDs)VS_(2)nanomaterials with specific electronic properties and multiphase microstructures have shown fascinating potential in the field of electro-magnetic wave(EMW)abso...Although VB-Group transition metal disulfides(TMDs)VS_(2)nanomaterials with specific electronic properties and multiphase microstructures have shown fascinating potential in the field of electro-magnetic wave(EMW)absorption,the efficient utilization of VS_(2)is limited by the technical bottleneck of its narrow effective absorption bandwidth(EAB)which is attributed to environmental instability and a deficient electromagnetic(EM)loss mechanism.In order to fully exploit the maximal utilization values of VS_(2)nanomaterials for EMW absorption through mitigating the chemical instability and optimizing the EM parameters,biomass-based glucose derived carbon(GDC)like sugar-coating has been decorated on the surface of stacked VS_(2)nanosheets via a facile hydrothermal method,followed by high-temperature carbonization.As a result,the modulation of doping amount of glucose injection solution(Glucose)could effectively manipulate the encapsulation degree of GDC coating on VS_(2)nanosheets,further imple-menting the EM response mechanisms of the VS_(2)/GDC hybrids(coupling effect of conductive loss,interfacial polarization,relaxation,dipole polarization,defect engineering and multiple reflections and absorptions)through regulating the conductivity and constructing multi-interface heterostructures,as reflected by the enhanced EMW absorption performance to a great extent.The minimum reflection loss(Rmin)of VS_(2)/GDC hybrids could reach52.8 dB with a thickness of 2.7 mm at 12.2 GHz.Surprisingly,compared with pristine VS_(2),the EAB of the VS_(2)/GDC hybrids increased from 2.0 to 5.7 GHz,while their environmental stability was effectively enhanced by virtue of GDC doping.Obviously,this work provides a promising candidate to realize frequency band tunability of EMW absorbers with exceptional perfor-mance and environmental stability.展开更多
Flexible and wearable electromagnetic interference(EMI)shielding material is one of the current research focuses in the field of EMI shielding.In this work,for the first time,WS_(2)-carbon fiber(WS_(2)-CF)composites a...Flexible and wearable electromagnetic interference(EMI)shielding material is one of the current research focuses in the field of EMI shielding.In this work,for the first time,WS_(2)-carbon fiber(WS_(2)-CF)composites are synthesized by implanting WS_(2),which has a multiphase structure and a large number of defects,onto the surface of carbon fiber(CF)by using a simple one-step hydrothermal method,and are applied to protect electronic devices from EMI.It is found that the EMI shielding performance of WS_(2)-CF is significantly improved,especially for those at Se and C-bands.At 2 GHz,the EMI shielding efficiency could reach 36.0 dB at a typical thickness of 3.00 mm of the composite,which is much better than that of pure CF(25.5 dB).Besides paving a novel avenue to optimize the electromagnetic shielding performance of flexible and wearable CF-based EMI shielding materials,which have great potential in the practical application for EMI shielding,this work provides a new paradigm for the design and synthesis of EMI shielding materials which have a broad application prospect.展开更多
基金financial support from the National Natural Science Foundation of China(Nos.21776026,22075034,and 22178037)the Liaoning Revitalization Talents Program,China(Nos.XLYC1902037 and XLYC2002114)the Natural Science Foundation of Liaoning Province of China(No.2021-MS-303)。
文摘Electromagnetic wave(EMW)-absorbing materials have considerable capacity in the military field and the prevention of EMW radiation from harming human health.However,obtaining lightweight,high-performance,and broadband EMW-absorbing material remains an overwhelming challenge.Creating dielectric/magnetic composites with customized structures is a strategy with great promise for the development of high-performance EMW-absorbing materials.Using layered double hydroxides as the precursors of bimetallic alloys and combining them with porous biomass-derived carbon materials is a potential way for constructing multi-interface heterostructures as efficient EMW-absorbing materials because they have synergistic losses,low costs,abundant resources,and light weights.Here,FeNi alloy nanosheet array/Lycopodium spore-derived carbon(FeNi/LSC)was prepared through a simple hydrothermal and carbonization method.FeNi/LSC presents ideal EMW-absorbing performance by benefiting from the FeNi alloy nanosheet array,sponge-like structure,capability for impedance matching,and improved dielectric/magnetic losses.As expected,FeNi/LSC exhibited the minimum reflection loss of-58.3 dB at 1.5 mm with 20wt%filler content and a widely effective absorption bandwidth of 4.92 GHz.FeNi/LSC composites with effective EMW-absorbing performance provide new insights into the customization of biomass-derived composites as high-performance and lightweight broadband EMW-absorbing materials.
基金Supported by a grant from the Key Sci-tech Research Project of Shanxi Province, China (No. 2003K10-G38)
文摘Objective: The significance of isolated high-grade prostatic intraepithelial neoplasia in initial biopsy as an predic-tor for prostate cancer has been extensively research, and the true relationship remnant is no clear till now. The aim of this study is to evaluate prediction value of cancer on repeat biopsy in patients with high-grade prostatic intraepithelial neoplasia, using multivariate analysis. Methods: Thirty-eight men with a diagnosis of isolated high-grade prostatic intraepithelial neo-plasia in initial needle biopsy were studies, in the Fist Affiliated Hospital of Medical School of Xi'an Jiaotong University, from January 2003 to March 2009. These samples were using immunostaining of p63 and 34βE12 and P504s, with a median fol-low-up of 525 (range, 7 to 1650) days, and to researched the incidence of subsequent prostate cancer, and to predicted the risk of prostate cancer in clinicopathological parameters of isolated high-grade prostatic intraepithelial neoplasia on repeat biopsies by logistic regression analysis. Results: There were 10 of 38 (26.3%) men with prostate cancer on repeat biopsies after diagnosis isolated high-grade prostatic intraepithelial neoplasia in initial biopsy, of the rates of prostate cancer were 80% for micropapillary and 75% for cribriform high-grade prostatic intraepithelial neoplasia (P < 0.05), respectively. The positive cores of isolated high-grade prostatic intraepithelial neoplasia was the important for the risk of prostate cancer using Multi-factor logistic regression analysis. The time range in 30 to 690 days was stronger risk for prostate cancer detection after diagnosis isolated HGPIN in initial biopsy. p63 and 34βE12 were disrupted positive expression, and P504S was weak posi-tive expression in the 61% isolated high-grade prostatic intraepithelial neoplasia. Conclusion: Isolated high-grade prostatic intraepithelial neoplasia on repeat biopsy conferred a 26.3% risk of prostate cancer, and this risk level is lower than the previ-ously reported risk of 24% to 58%. The number of positive cores and the histopathological pattern with high-grade prostatic intraepithelial neoplasia on initial biopsy was significantly associated with the risk of cancer.
基金This work was sup-ported in part by grants from the following sources:the National Natural Science Foundation of China(82203233,82202966,82173142,82302987,82303534,and 81972636)the Natural Science Foundation of Hunan Province(2023JJ60469,2023JJ40413,2023JJ30372,2023JJ30375,2022JJ80078,and 2020JJ5336)+8 种基金the Research Project of Health Commission of Hunan Province(202203034978,202109031837,and 20201020)Key Research and Devel-opment Program of Hunan Province(2022SK2051)Hunan Provincial Science and Technology Department(2020TP1018)the Changsha Science and Technology Board(kh2201054)the Changsha Municipal Natural Science Foundation(kq2014209)Ascend Foundation of National Cancer Center(NCC201909B06)Hunan Cancer Hospital Climb Plan(ZX2020001-3 and YF2020002)the Science and Technology Innovation Program of Hunan Province(2023RC3199,2023SK4034 and 2023RC1073)by China Postdoctoral Science Foundation(2022TQ0104 and 2022M721118).
文摘Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular functions.Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell death.Ferroptosis is a recently discovered form of iron-dependent programmed cell death.The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression.However,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well understood.Here,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process.Additionally,we provided a detailed overview of agents used to induce cancer ferroptosis.We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell killing.The combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.
基金supported by the National Natural Science Foundation of China(52102368,52072192,51977009)Regional Joint Fund for Basic Research and Applied Basic Research of Guangdong Province(No.2020SA001515110905).
文摘Although VB-Group transition metal disulfides(TMDs)VS_(2)nanomaterials with specific electronic properties and multiphase microstructures have shown fascinating potential in the field of electro-magnetic wave(EMW)absorption,the efficient utilization of VS_(2)is limited by the technical bottleneck of its narrow effective absorption bandwidth(EAB)which is attributed to environmental instability and a deficient electromagnetic(EM)loss mechanism.In order to fully exploit the maximal utilization values of VS_(2)nanomaterials for EMW absorption through mitigating the chemical instability and optimizing the EM parameters,biomass-based glucose derived carbon(GDC)like sugar-coating has been decorated on the surface of stacked VS_(2)nanosheets via a facile hydrothermal method,followed by high-temperature carbonization.As a result,the modulation of doping amount of glucose injection solution(Glucose)could effectively manipulate the encapsulation degree of GDC coating on VS_(2)nanosheets,further imple-menting the EM response mechanisms of the VS_(2)/GDC hybrids(coupling effect of conductive loss,interfacial polarization,relaxation,dipole polarization,defect engineering and multiple reflections and absorptions)through regulating the conductivity and constructing multi-interface heterostructures,as reflected by the enhanced EMW absorption performance to a great extent.The minimum reflection loss(Rmin)of VS_(2)/GDC hybrids could reach52.8 dB with a thickness of 2.7 mm at 12.2 GHz.Surprisingly,compared with pristine VS_(2),the EAB of the VS_(2)/GDC hybrids increased from 2.0 to 5.7 GHz,while their environmental stability was effectively enhanced by virtue of GDC doping.Obviously,this work provides a promising candidate to realize frequency band tunability of EMW absorbers with exceptional perfor-mance and environmental stability.
基金This work was supported by the National Natural Science Foundation of China under Grant No.52102368,51772160,51977009.China Postdoctoral Science Foundation(Grant No.2020M682029)Regional Joint Fund for Basic Research and Applied Basic Research of Guangdong Province(No.2020SA001515110905).
文摘Flexible and wearable electromagnetic interference(EMI)shielding material is one of the current research focuses in the field of EMI shielding.In this work,for the first time,WS_(2)-carbon fiber(WS_(2)-CF)composites are synthesized by implanting WS_(2),which has a multiphase structure and a large number of defects,onto the surface of carbon fiber(CF)by using a simple one-step hydrothermal method,and are applied to protect electronic devices from EMI.It is found that the EMI shielding performance of WS_(2)-CF is significantly improved,especially for those at Se and C-bands.At 2 GHz,the EMI shielding efficiency could reach 36.0 dB at a typical thickness of 3.00 mm of the composite,which is much better than that of pure CF(25.5 dB).Besides paving a novel avenue to optimize the electromagnetic shielding performance of flexible and wearable CF-based EMI shielding materials,which have great potential in the practical application for EMI shielding,this work provides a new paradigm for the design and synthesis of EMI shielding materials which have a broad application prospect.