Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system.The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-...Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system.The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine.The mice were subjected to 17β estradiol injection into the lateral ventricle.Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice.Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson's disease.展开更多
文摘Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system.The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine.The mice were subjected to 17β estradiol injection into the lateral ventricle.Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice.Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson's disease.
