Building the new countryside construction database plays an important role in improving the construction efficiency,and enhancing the level of major project management.On the basis of detailed analysis of features of ...Building the new countryside construction database plays an important role in improving the construction efficiency,and enhancing the level of major project management.On the basis of detailed analysis of features of the new countryside construction data,we give an overview of the database design based on ArcSDE and SQL Server,and elaborate the association between data classification organization,database conceptual design,logical design,spatial data,and thematic attribute data.Finally,taking the provincial new countryside demonstration zone in Yanjiang District of Sichuan Province for example,we build the new countryside construction database.展开更多
Soil is the most biologically abundant ecosystem on the earth.Soil biodiversity has significant impact on maintaining soil ecological balance and agricultural production,especially on healthy growth and disease contro...Soil is the most biologically abundant ecosystem on the earth.Soil biodiversity has significant impact on maintaining soil ecological balance and agricultural production,especially on healthy growth and disease control of plants.Therefore,it is of great significance to study soil biodiversity.This paper reviewed the role of soil biodiversity in plant growth.First of all,the history of soil biodiversity was introduced.Secondly,the composition of soil biodiversity was introduced,and the role of soil biodiversity in regulating the quantity and species of soil organisms,maintaining the balance and stability of soil system,participating in nutrient circulation and energy flow,and promoting plant health were discussed based on the interactions among microbial diversity,fauna diversity and plant diversity.Finally,combined with the background of advocating the protection of soil biodiversity in the great time,the potential factors threatening soil biodiversity were analyzed.展开更多
[Objectives]To find a sustainable production model for potato at low latitude plateau in winter in Yunnan Province.[Methods]Xuanshu 2 potato variety was tested in prefectures of Yunnan Province.Soil covering experimen...[Objectives]To find a sustainable production model for potato at low latitude plateau in winter in Yunnan Province.[Methods]Xuanshu 2 potato variety was tested in prefectures of Yunnan Province.Soil covering experiment was conducted in two trials(open field experiment and green house potted experiment).Impacts of three cultivation factors were analyzed:(i)three cultivation models(T1,T2 and T3),(ii)planting density(T1,T2 and T3),(iii)soil covering(T1,T2,T3,T4)on plant growth,and yield production.[Results]The soil moisture content,temperature,roots growth,stems development,leaf area index,and number-weight of tubers per plant and per plot(g)have significantly increased with commercial yield average of 45 t/ha.[Conclusions]The combination of this method with modern agriculture mechanization should be further popularized and applied in large scale planting in regions with climatic conditions similar winter season in Yunnan Province,so as to make contribution to the satisfaction of the world population potato consumption.展开更多
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen ...Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the progression and exacerbation of various pathological states. Nevertheless, NETs exhibit dual functionalities in certain pathological contexts. While NETs may act as autoantigens, aggregated NET complexes can function as inflammatory mediators by degrading proinflammatory cytokines and chemokines. The delineation of molecules and signaling pathways governing NET formation aids in refining our appreciation of NETs’ role in immune homeostasis, inflammation, autoimmune diseases, metabolic dysregulation, and cancer. In this comprehensive review, we delve into the multifaceted roles of NETs in both homeostasis and disease, whilst discussing their potential as therapeutic targets. Our aim is to enhance the understanding of the intricate functions of NETs across the spectrum from physiology to pathology.展开更多
The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound healing.Dermal fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to injur...The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound healing.Dermal fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to injury.Papillary fibroblasts play central regulatory roles in the regeneration of skin appendages during wound healing.Inspired by the phenomenon where bait for grass carp can attract grouped grass carps to a fishing spot soon,“Grass Carp Fishing”multifunctional hydrogels,that is,codelivery of an antibody of leucine-rich repeats and immunoglobulin-like domains 1(Lrig1)on the surface of papillary fibroblasts and insulinlike growth factor 1(IGF1)with recruitment function,can recruit papillary fibroblasts.In the experiments,carboxymethyl chitosan showed positive effects in promoting cell proliferation and neovascularization,while dopamine-grafted gelatin was effective in stabilizing the structure and prolonging the degradation time.The sustained release of Lrig1 antibodies and IGF1 from injectable self-healing multifunctional hydrogels persistently accelerated the migration and proliferation of Lrig1+fibroblasts.The in vivo results from a full-thickness cutaneous wound model showed that injectable self-healing multifunctional hydrogel accelerated wound healing and skin regeneration through the recruitment of Lrig1+papillary fibroblasts in wound tissue.Our findings reveal an injectable self-healing multifunctional hydrogel for regeneration,a promising approach to promoting skin wound healing.展开更多
基金Supported by Fundamental Research Project of Sichuan Provincial Department of Finance in 2012
文摘Building the new countryside construction database plays an important role in improving the construction efficiency,and enhancing the level of major project management.On the basis of detailed analysis of features of the new countryside construction data,we give an overview of the database design based on ArcSDE and SQL Server,and elaborate the association between data classification organization,database conceptual design,logical design,spatial data,and thematic attribute data.Finally,taking the provincial new countryside demonstration zone in Yanjiang District of Sichuan Province for example,we build the new countryside construction database.
基金Supported by High-level Talents Program of Basic and Applied Basic Research Program of Hainan Province(2019RC332)。
文摘Soil is the most biologically abundant ecosystem on the earth.Soil biodiversity has significant impact on maintaining soil ecological balance and agricultural production,especially on healthy growth and disease control of plants.Therefore,it is of great significance to study soil biodiversity.This paper reviewed the role of soil biodiversity in plant growth.First of all,the history of soil biodiversity was introduced.Secondly,the composition of soil biodiversity was introduced,and the role of soil biodiversity in regulating the quantity and species of soil organisms,maintaining the balance and stability of soil system,participating in nutrient circulation and energy flow,and promoting plant health were discussed based on the interactions among microbial diversity,fauna diversity and plant diversity.Finally,combined with the background of advocating the protection of soil biodiversity in the great time,the potential factors threatening soil biodiversity were analyzed.
基金Major Science and Technology Special Program of Yunnan Provincial Department of Science and Technology(202102AE090018)Key Research and Development Program of Hainan Province(ZDYF2021XDNY291).
文摘[Objectives]To find a sustainable production model for potato at low latitude plateau in winter in Yunnan Province.[Methods]Xuanshu 2 potato variety was tested in prefectures of Yunnan Province.Soil covering experiment was conducted in two trials(open field experiment and green house potted experiment).Impacts of three cultivation factors were analyzed:(i)three cultivation models(T1,T2 and T3),(ii)planting density(T1,T2 and T3),(iii)soil covering(T1,T2,T3,T4)on plant growth,and yield production.[Results]The soil moisture content,temperature,roots growth,stems development,leaf area index,and number-weight of tubers per plant and per plot(g)have significantly increased with commercial yield average of 45 t/ha.[Conclusions]The combination of this method with modern agriculture mechanization should be further popularized and applied in large scale planting in regions with climatic conditions similar winter season in Yunnan Province,so as to make contribution to the satisfaction of the world population potato consumption.
基金National Institute of Health grants R01-CA214865 to A.T.State funding within the UVA Comprehensive Cancer Center“IDEA-Cancer pilot award”,“Cancer Therapeutics(CRX)pilot award”to H.Z.National Natural Science Foundation of China Grant Number 82200588 to H.W.
文摘Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the progression and exacerbation of various pathological states. Nevertheless, NETs exhibit dual functionalities in certain pathological contexts. While NETs may act as autoantigens, aggregated NET complexes can function as inflammatory mediators by degrading proinflammatory cytokines and chemokines. The delineation of molecules and signaling pathways governing NET formation aids in refining our appreciation of NETs’ role in immune homeostasis, inflammation, autoimmune diseases, metabolic dysregulation, and cancer. In this comprehensive review, we delve into the multifaceted roles of NETs in both homeostasis and disease, whilst discussing their potential as therapeutic targets. Our aim is to enhance the understanding of the intricate functions of NETs across the spectrum from physiology to pathology.
基金Funding for this study was provided by the Natural Science Foundation of Jiangsu Province(No.BK20191141)Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee(Nos.BJ2020044,BJ2020057,and HB2020043)+2 种基金Fundamental Research Funds of Health and Family Planning Commission of Wuxi(No.M202024)the Special Program for Translational Medicine Research of Wuxi Translational Medicine Center(Nos.2020DHYB07 and 2020DHYB03)Key Special Project of Precision Medicine of Wuxi Health Commission(No.J202101).
文摘The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound healing.Dermal fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to injury.Papillary fibroblasts play central regulatory roles in the regeneration of skin appendages during wound healing.Inspired by the phenomenon where bait for grass carp can attract grouped grass carps to a fishing spot soon,“Grass Carp Fishing”multifunctional hydrogels,that is,codelivery of an antibody of leucine-rich repeats and immunoglobulin-like domains 1(Lrig1)on the surface of papillary fibroblasts and insulinlike growth factor 1(IGF1)with recruitment function,can recruit papillary fibroblasts.In the experiments,carboxymethyl chitosan showed positive effects in promoting cell proliferation and neovascularization,while dopamine-grafted gelatin was effective in stabilizing the structure and prolonging the degradation time.The sustained release of Lrig1 antibodies and IGF1 from injectable self-healing multifunctional hydrogels persistently accelerated the migration and proliferation of Lrig1+fibroblasts.The in vivo results from a full-thickness cutaneous wound model showed that injectable self-healing multifunctional hydrogel accelerated wound healing and skin regeneration through the recruitment of Lrig1+papillary fibroblasts in wound tissue.Our findings reveal an injectable self-healing multifunctional hydrogel for regeneration,a promising approach to promoting skin wound healing.