Chronic pain is a major cause of suffering that often accompanies diseases and therapies,affecting approximately 20%of individuals at some point in their lives.However,current treatment modalities,such as anesthetic a...Chronic pain is a major cause of suffering that often accompanies diseases and therapies,affecting approximately 20%of individuals at some point in their lives.However,current treatment modalities,such as anesthetic and antipyretic analgesics,have limitations in terms of efficacy and side effects.Nanomedical technology offers a promising avenue to overcome these challenges and introduce new therapeutic mechanisms.This article reviews the recent research on nanomedicine analgesics,integrating analyses of neuroplasticity changes in neurons and pathways related to the transition from acute to chronic pain.Furthermore,it explores potential future strategies using nanomaterials,aiming to provide a roadmap for new analgesic development and improved clinical pain management.By leveraging nanotechnology,these approaches hold the potential to revolutionize pain treatment by delivering targeted and effective relief while minimizing side effects.展开更多
基金National Natural Science Youth Fund,Grant/Award Number:82202326Natural Science Foundation of Shanghai Municipality,Grant/Award Number:21ZR1405300+4 种基金National Natural Science Foundation of China Youth Fund,Grant/Award Number:52322213Shanghai Rising-Star Program,Grant/Award Number:21QA1400900National Funds for General Projects,Grant/Award Number:52272269Innovation Program of Shanghai Municipal Education Commission,Grant/Award Number:2023ZKZD01Key Program of National Natural Science Foundation of China,Grant/Award Number:22235004。
文摘Chronic pain is a major cause of suffering that often accompanies diseases and therapies,affecting approximately 20%of individuals at some point in their lives.However,current treatment modalities,such as anesthetic and antipyretic analgesics,have limitations in terms of efficacy and side effects.Nanomedical technology offers a promising avenue to overcome these challenges and introduce new therapeutic mechanisms.This article reviews the recent research on nanomedicine analgesics,integrating analyses of neuroplasticity changes in neurons and pathways related to the transition from acute to chronic pain.Furthermore,it explores potential future strategies using nanomaterials,aiming to provide a roadmap for new analgesic development and improved clinical pain management.By leveraging nanotechnology,these approaches hold the potential to revolutionize pain treatment by delivering targeted and effective relief while minimizing side effects.
