Welcome to the journal Data Science and Informetrics(DSI).The interdisciplinary fields of data science and informetrics have been extremely active in recent years.DsI is created to publish research results in these fi...Welcome to the journal Data Science and Informetrics(DSI).The interdisciplinary fields of data science and informetrics have been extremely active in recent years.DsI is created to publish research results in these fields and to promote innovative data-driven interdisciplinary research across these fields.展开更多
Welcome to the journal Data Science and Informetrics(DSI).The interdisciplinary fields of data science and informetrics have been extremely active in recent years.DsI is created to publish research results in these fi...Welcome to the journal Data Science and Informetrics(DSI).The interdisciplinary fields of data science and informetrics have been extremely active in recent years.DsI is created to publish research results in these fields and to promote innovative data-driven interdisciplinary research across these fields.展开更多
The modification and functionalization of peptides is of great significance in modern biotechnology and drug development. Here we report a highly reactive Michael-type warhead for the covalently modification of cystei...The modification and functionalization of peptides is of great significance in modern biotechnology and drug development. Here we report a highly reactive Michael-type warhead for the covalently modification of cysteine on peptide and protein. By installing a vinyl group onto a methionine residue of peptide,the produced vinyl sulfonium can be efficiently nucleophilic added by appropriate cysteine residue of this peptide, and thus yield a cyclized peptide. This peptide cyclization strategy was proven to exhibit improved cell penetration and good stability. Moreover, a peptide ligand bearing vinyl sulfonium could covalently bind to the cysteine in the target protein, indicating the potential of vinyl sulfonium as a novel warhead for developing covalent peptide inhibitor.展开更多
文摘Welcome to the journal Data Science and Informetrics(DSI).The interdisciplinary fields of data science and informetrics have been extremely active in recent years.DsI is created to publish research results in these fields and to promote innovative data-driven interdisciplinary research across these fields.
文摘Welcome to the journal Data Science and Informetrics(DSI).The interdisciplinary fields of data science and informetrics have been extremely active in recent years.DsI is created to publish research results in these fields and to promote innovative data-driven interdisciplinary research across these fields.
基金financial support from the National Key Research and Development Program"Synthetic Biology"Key Special Project of China (No. 2018YFA0902504)the China Postdoctoral Science Foundation (No. 2021M690220)+7 种基金the National Natural Science Foundation of China (Nos. 21778009 and21977010)the Natural Science Foundation of Guangdong Province(Nos. 2019A1515110487, 2020A1515010522 and 2019A1515111184)the Shenzhen Science and Technology Innovation Committee (Nos. JCYJ20180507181527112, JCYJ20180508152213145, and JCYJ20170817172023838)the Foundation for Basic and Applied Research of Guangdong Province (No. 2019A1515110489)Guangdong Medical Science Foundation (No. A2021413)financial support from Beijing National Laboratory of Molecular Science Open Grant (No. BNLMS20160112)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions (No. 2019SHIBS0004)supported by the high-performance computing platform of Peking University。
文摘The modification and functionalization of peptides is of great significance in modern biotechnology and drug development. Here we report a highly reactive Michael-type warhead for the covalently modification of cysteine on peptide and protein. By installing a vinyl group onto a methionine residue of peptide,the produced vinyl sulfonium can be efficiently nucleophilic added by appropriate cysteine residue of this peptide, and thus yield a cyclized peptide. This peptide cyclization strategy was proven to exhibit improved cell penetration and good stability. Moreover, a peptide ligand bearing vinyl sulfonium could covalently bind to the cysteine in the target protein, indicating the potential of vinyl sulfonium as a novel warhead for developing covalent peptide inhibitor.
